ABSTRACT
The authors studied the influence of lozartan -angiotensin II antagonist on the state of cardiohemodynamics and function of vessel endothelial cell in patients with CODL in the process of the treatment. 90 patients with stage II or III CODL in remission (average age is 50.46+/-5.1) have been observed. The average duration of the disease was 16.2+/-7.6 years. 30 patients received additionally lozartan -angiotensin II antagonist. Cardiohemodynamics has been assessed using Doppler ultrasonography. To assess the state of function of vessel endothelial cell the authors carried out reactive hyperemia test and calculated the level of nitrite nitrogen in blood plasma and erythrocytes. The duration of observation was 12 weeks. Losartan appeared to be effective in patients with CODL to correct compromised cardiohemodynamics. Losartan dicreases the disfunction of endothelial cell and has cardioprotective properties.
