Periodic bursts of Jovian non-Io decametric radio emission.

During the years 2000-2011 the radio instruments onboard Cassini, Wind and STEREO spacecraft have recorded a large amount of the Jovian decametric radio emission (DAM). In this paper we report on the analysis of the new type of Jovian periodic radio bursts recently revealed in the decametric frequency range. These bursts, which are non-Io component of DAM, are characterized by a strong periodic reoccurrence over several Jovian days with a period [Formula: see text] longer than the rotation rate of the planet's magnetosphere (System III). The bursts are typically observed between 4 and 12 MHz and their occurrence probability has been found to be significantly higher in the sector of Jovian Central Meridian Longitude between 300° and 60° (via 360°). The stereoscopic multispacecraft observations have shown that the radio sources of the periodic bursts radiate in a non-axisymmetric hollow cone-like pattern and sub-corotate with Jupiter remaining active during several planet's rotations. The occurrence of the periodic non-Io DAM bursts is strongly correlated with pulses of the solar wind ram pressure at Jupiter. Moreover the periodic bursts exhibit a tendency to occur in groups every [Formula: see text] days. The polarization measurements have shown that the periodic bursts are right hand polarized radio emission associated with the Northern magnetic hemisphere of Jupiter. We suggest that periodic non-Io DAM bursts may be connected with the interchange instability in Io plasma torus triggered by the solar wind.

Radio and plasma wave observations at Saturn from Cassini's approach and first orbit.

We report data from the Cassini radio and plasma wave instrument during the approach and first orbit at Saturn. During the approach, radio emissions from Saturn showed that the radio rotation period is now 10 hours 45 minutes 45 +/- 36 seconds, about 6 minutes longer than measured by Voyager in 1980 to 1981. In addition, many intense impulsive radio signals were detected from Saturn lightning during the approach and first orbit. Some of these have been linked to storm systems observed by the Cassini imaging instrument. Within the magnetosphere, whistler-mode auroral hiss emissions were observed near the rings, suggesting that a strong electrodynamic interaction is occurring in or near the rings.

Control of Jupiter's radio emission and aurorae by the solar wind.

Radio emissions from Jupiter provided the first evidence that this giant planet has a strong magnetic field and a large magnetosphere. Jupiter also has polar aurorae, which are similar in many respects to Earth's aurorae. The radio emissions are believed to be generated along the high-latitude magnetic field lines by the same electrons that produce the aurorae, and both the radio emission in the hectometric frequency range and the aurorae vary considerably. The origin of the variability, however, has been poorly understood. Here we report simultaneous observations using the Cassini and Galileo spacecraft of hectometric radio emissions and extreme ultraviolet auroral emissions from Jupiter. Our results show that both of these emissions are triggered by interplanetary shocks propagating outward from the Sun. When such a shock arrives at Jupiter, it seems to cause a major compression and reconfiguration of the magnetosphere, which produces strong electric fields and therefore electron acceleration along the auroral field lines, similar to the processes that occur during geomagnetic storms at the Earth.

Cellular mechanisms of CNS pericytes.

Three major functional roles have been ascribed to pericytes associated with central nervous system microvasculature-contractility, regulation o f endothelial cell activity, and macrophage activity. A host of different cell factors and signalling agents appear to be involved with these cellular functions, some effecting the pericyte and others produced by this cell. These include neuromodulators, vasoactive peptides, metabolic factors, growth factors and cytokines. The specific compounds and their actions are collectively viewed in an effort to provide an overall picture of the regulation of pericyte functional activity. This small vascular cell is emerging as a significant entity in several physiological processes through the functions of above; these processes include control of blood flow, regulation of vascular development and immune responses. Defining the regulatory agents and their mechanisms is key to understanding the role that pericytes play in these processes. Because these cells have begun to receive increasing attention in neurobiological studies, an overview of signalling properties should be timely and beneficial.

Effects of chronic ethanol ingestion on mid-latency auditory evoked potentials depend on length of exposure.

We hypothesized that chronic ethanol ingestion is associated with modifications in components of mid-latency auditory evoked potentials (MAEPs). To test this, male Long Evans rats were administered 10% ethanol in drinking water as the sole fluid source for 3, 6, or 9 months. MAEPs were obtained and compared to age-matched control groups. MAEPs were obtained from additional rats after 4 weeks of abstinence. Data were obtained for varying frequencies (4, 8, 16, 24, 32 kHz) and intensities (65, 75, 85 dB SPL). Three months of ethanol exposure was associated with increased latencies and amplitudes of Na and Pa. MAEP components recovered and returned to control values after 4 weeks' abstinence following 3 months of EtOH exposure. Few significant differences were observed in the ethanol-treated or abstinent group after 6 months' exposure. However, 9 months of ethanol exposure revealed a significant increase in latencies and decrease in amplitudes of both Na and Pa components. After 4 weeks of abstinence, the Na and Pa component peak latencies appeared earlier than age-matched controls. The Na and Pa peak amplitudes were slightly greater than the ethanol-treated group; however, they did not recover to control values. These findings suggest that chronic ethanol consumption may produce time-dependent structural and/or neurochemical alterations in substrates for cortical information processing, which may be irreversible. In the present paradigm, this irreversibility may occur after 6 or more months of ethanol intake, and may be detected with the use of MAEPs.

Chronic ethanol ingestion produces cholinergic hypofunction in rat brain.

Alterations in cholinergic function due to prolonged ethanol exposure (up to 9 months) were assessed by choline acetyltransferase (ChAT) activity and high-affinity choline uptake (HAChU) in three brain regions of the Long-Evans rat: frontal cortex, parietal cortex, and region of the nucleus basalis of Meynert (NbM). No statistically significant changes were found in ChAT activity in the 3-month group; however, ChAT activity was decreased in both the frontal cortex (-32%) and NbM region (-22%) after 6 months of ethanol exposure. ChAT activity in the parietal cortex was increased 30% after 6 months. Nine months of exposure significantly decreased ChAT activity in all three brain regions. No significant differences were observed in high-affinity choline uptake after 3 months of ethanol exposure. However, after 6 months of ethanol exposure HAChU was decreased to 51% of control values in the frontal cortex. There was a simultaneous increase in HAChU to 43% and 178% of control values in the NbM and parietal cortex, respectively. However, choline uptake was significantly decreased in the frontal cortex and NbM region after 9 months of exposure. The results indicate a neurotoxic effect of prolonged intake of ethanol on the basal forebrain cholinergic projection system, which may cause impairment of cholinergic innervation of target areas of the basal nucleus complex.

Chronic ethanol ingestion alters parameters of mid-latency auditory evoked potentials in male rats.

The purpose of this study was to determine the effects of chronic ethanol ingestion on components of mid-latency auditory evoked potentials (MAEPs). Male Sprague-Dawley rats were administered 10% ethanol in drinking water for 10 months. MAEPs were obtained and compared to age-matched controls provided tap water. Data were obtained for varying frequencies (4, 8, 16, 24, and 32 kHz) and intensities (65, 75, and 85 dB sound pressure level). Ethanol treatment was associated with increased latencies, as well as decreased amplitudes of Na and Pa. The effects were most prominent for MAEP component Pa, but also appear for component Na. We suggest that chronic alcohol consumption induces structural and/or neurochemical alterations in substrates for cortical information processing.

A role for acetylcholine in conditioning-related responses of rat frontal cortex neurons: microiontophoretic evidence.

In an associative conditioning paradigm, an auditory stimulus (CS+) was paired with rewarding medial forebrain bundle stimulation or a tone of different frequency (CS-) was presented without pairing. After training, slow potential (SP) and single neuron responses were recorded from rat frontal cortex. When cortical SP responses indicated the development of discrimination between CS+ and CS- tones, single neurons could be isolated that exhibited a discriminative response to CS+. Seventy-three percent of the 56 neurons which discriminated between CS+ and CS- were excited by the paired tone while the remainder were inhibited. Iontophoretically applied acetylcholine increased spontaneous firing rate in 90% of the excited cells and 87% of the inhibited cells. Iontophoretic administration of a muscarinic receptor antagonist, either atropine or tropicamide, during trial presentation attenuated the conditioning-related response to CS+ as well as the response to acetylcholine in the majority of neurons. The largest group of discriminating neurons were excited by both CS+ and acetylcholine, and both responses were suppressed by the antagonists. The results provide evidence that conditioning-related responses of a major population of frontal cortex neurons are modulated by cholinergic input, a portion of which may originate in the basal forebrain area. There also may be a significant non-cholinergic influence on these neuronal responses.

Potentiation of cholinergic activity with pyridino[1,2-a]imidazo[5,4-b]indole: in vitro studies.

1. Effects of a novel imidazoindole derivative on cholinergic function were studied in isolated tissue preparations. 2. The compound demonstrated a dose-dependent (10(-11)-10(-9) potentiation (20-60%) of acetylcholine induced tension in guinea pig ileal tissue. 3. Increases in the size of end-plate potentials and nerve evoked muscle twitches were observed in frog nerve-skeletal muscle preparations. 4. Cholinesterase activity was not inhibited. 5. The results suggest that the compound has actions at the post-synaptic muscarinic receptor complex in smooth muscle and causes pre-synaptic increases in ACh release at the neuromuscular junction.

Discriminative conditioning-related slow potential and single-unit responses in the frontal cortex of urethane-anesthetized rats.

A model is described for obtaining long-term and stable discriminative conditioning-related slow-potential and single-unit responses from the frontal cortex of urethane-anesthetized rats. Responses were recorded and analyzed to reinforced (rewarding medial forebrain bundle stimulation) and non-reinforced tone cues. In the present study, cortical event-related slow potentials provided an adequate index of the level of discriminative conditioning. Single-unit response patterns are described for 57 neurons which demonstrated a discriminative response to either the reinforced or non-reinforced tone cue.