ABSTRACT
In experiments with Raji cells, it has been shown that the serum growth factors activate the growth of gamma-irradiated (0.36 mGy/day) culture. The authors discuss the role of radiation stimulation of membrane receptors in recepting natural effectors.
Subject(s)
Lymphocytes/radiation effects , Receptors, Cell Surface/radiation effects , Cell Division/radiation effects , Cell Line , Cells, Cultured/cytology , Cells, Cultured/radiation effects , Culture Media , Dose-Response Relationship, Radiation , Gamma Rays , Humans , Lymphocytes/cytology , Receptors, Cell Surface/physiologyABSTRACT
A study was made of the response of adenylate cyclase of cytoplasmic membranes of pulmonary tissue to chronic gamma irradiation of rats at a low-dose rate (0.036 cGy/day). The adenylate cyclase complex receptors were shown to respond to such exposure by activation of the enzyme they control and by being more sensitive to their specific effector, isoproterenol. The role of receptors in the manifestation of radiation hormesis is discussed.
Subject(s)
Adenylyl Cyclases/radiation effects , Lung/radiation effects , Adenylyl Cyclases/metabolism , Animals , Cell Membrane/enzymology , Cell Membrane/radiation effects , Cesium Radioisotopes , Dose-Response Relationship, Radiation , Gamma Rays , Lung/enzymology , Male , Rats , Rats, Inbred Strains , Time FactorsABSTRACT
Development of rat pups was shown to accelerate (body mass made up 121% of control) after gamma-irradiation on day 21 of the postnatal development (2.88 cGy, dose-rate of 0.12 cGy/h). Higher cumulative doses (14.4 and 144 cGy) did not influence the body mass growth, and inhibition was only caused by doses exceeding 150 cGy.
Subject(s)
Radiation Effects , Animals , Animals, Newborn/growth & development , Body Weight/radiation effects , Cesium Radioisotopes , Gamma Rays , Male , Physical StimulationABSTRACT
The response of the receptor of plant origin, phytochrome and the receptor of rat lung cytoplasmic membrane adenylate cyclase to chronic, growth- and development-stimulating low-dose gamma-radiation (0.36 and 0.036 cGy/day) has been studied. The influence of radiation results in sensitization of receptors to specific effectors and receptor-mediated stimulation of corresponding enzymes.
Subject(s)
Gamma Rays , Receptors, Cell Surface/radiation effects , Adenylyl Cyclases/biosynthesis , Animals , Carotenoids/biosynthesis , Cells, Cultured , Phenylalanine Ammonia-Lyase/biosynthesis , Rats , Rats, Inbred StrainsABSTRACT
Basal and stimulated activity of adenylate cyclase (cyclizing ATP-pyrophosphate lyase, E.C. 4.6.1.1., AC) in plasma membranes of pulmonary tissue was being studied during a year after fractionated irradiation of rats (2 GyX3). Basal and hormone-stimulated activity of AC was shown to vary significantly from normal 6 and 12 months after irradiation. The exposed membranes responded differently to AC activation by isoproterenol and F-.
