Subject(s)
Immune Tolerance/radiation effects , Lymphocytes/immunology , Microwaves/adverse effects , Animals , Bone Marrow/pathology , Bone Marrow/radiation effects , Dose-Response Relationship, Radiation , Humans , In Vitro Techniques , Lymphocyte Activation/radiation effects , Lymphopenia/etiology , Mice , Rabbits , Radiation Dosage , Radiation Injuries, Experimental/etiology , Radiation, Nonionizing , RatsABSTRACT
Repeated local exposure (6 sessions) of rat sarcoma 45 to ultrahigh-frequency hyperthermia (41.5--42.5 degrees C in the tumor for 30 minutes per session) and x-ray radiation (a single dose of 8 Gy) irrespective of the succession of their application enables complete resolution of the tumor to be attained at the logarithmic stage of its growth.
Subject(s)
Diathermy , Radio Waves , Sarcoma, Experimental/therapy , Animals , Male , Radiotherapy Dosage , Rats , X-RaysABSTRACT
A mathematical model of thermal heating of animal exposed to UHF-irradiation is suggested. Besides physical heat transfer between the organism and its surroundings, the model takes into account physiological mechanism of thermal regulation-hypernea and hyperhidrosis. Possible evaluation of exposure limits for microwave irradiation is considered on the basis of the model. Prediction for the model are well consistent with GOST (USSR Government Standard) requirements under the assumption that utmost safety increase of the body temperature in UHF-field is 0.01 degrees C.
Subject(s)
Body Temperature/radiation effects , Radio Waves , Humans , Mathematics , Maximum Allowable Concentration , Models, Biological , Respiration/radiation effects , Sweating/radiation effects , USSRABSTRACT
Changes of the rectal temperature during the day were determined in CBA mice and Wistar rats subjected to the total body irradiation with microwaves of different intensity. Dependence of these indices on keeping the animals in containers for irradiation and temperature reactions, and survival of the animals after exposure to UHF microwaves of various intensity were investigated. As shown, temperature rise and survival of the animals depended on the current intensity density and the action duration, the rectal temperature elevation during the irradiation; a pronounced reduction of this index following irradiation may be considered as a prognostic sign of affection with the UHF microwave field.
