ABSTRACT
The study failed to show a stimulating effect of hyperbaric oxygen on growth and metastatic spreading of sarcoma 37 transplanted subcutaneously or intravenously to female SHR mice, melanoma B16 intramuscularly transplanted to female C57/Bl mice and methylcholanthrene-induced tumors in female albino noninbred rats. An insignificant inhibitory effect of hyperbaric oxygen on transplantable tumor growth and development of inducible ones in experimental animals was observed.
Subject(s)
Hyperbaric Oxygenation , Neoplasms, Experimental/therapy , Animals , Female , Melanoma, Experimental/pathology , Melanoma, Experimental/therapy , Methylcholanthrene , Mice , Mice, Inbred C57BL , Neoplasm Metastasis , Neoplasm Transplantation , Neoplasms, Experimental/chemically induced , Neoplasms, Experimental/pathology , RatsABSTRACT
Treatment with such analgetics as analginum, promedol and pantopon was shown experimentally either to inhibit or to stimulate the growth of sarcoma-37 and its dissemination. It was also found to reduce the tumor growth--stimulating effect of operative trauma.
Subject(s)
Analgesics/therapeutic use , Sarcoma 37/drug therapy , Sarcoma, Experimental/drug therapy , Amputation, Surgical , Animals , Dipyrone/therapeutic use , Drug Evaluation, Preclinical , Female , Lung Neoplasms/drug therapy , Lung Neoplasms/physiopathology , Lung Neoplasms/secondary , Mice , Neoplasm Transplantation , Opium/therapeutic use , Promedol/therapeutic use , Sarcoma 37/physiopathology , Time FactorsABSTRACT
Present work is based on the data of experimental studies on the influence of inhalatory (ether, chloroform, halothane and methoxyfluorane) and intravenous anaesthesia (neurovegetative block and neuroleptoanalgesia) upon the tumour growth and metastasization as well as the level of corticosteronemia in surgical trauma. It has been revealed that the narcosis may change the course of the tumorous process both by means of its action on the endocrine part of the organism-tumour system and immediately (halothane) due to its cytostatic action. Obviously, anaesthesia may appear one of the factors influencing the results of multifactoral therapy of tumorous diseases.
Subject(s)
Anesthesia, Inhalation , Anesthesia, Intravenous , Corticosterone/blood , Lung Neoplasms/secondary , Lymphoma, Non-Hodgkin/pathology , Sarcoma 37/pathology , Sarcoma, Experimental/pathology , Animals , DNA/biosynthesis , Ether/pharmacology , Female , Halothane/pharmacology , Mice , Mitotic Index/drug effects , Neuroleptanalgesia , Rats , Sarcoma 37/metabolismABSTRACT
The modifying influence of anaestesia on tumourigenic process (its stimulative or inhibitory effect upon tumour and metastasis growth) was established. It may occur indirectly, i.e. through endocrine link of the host-tumour system, and due to cytostatic effect of the anaesthetic drug (fluothane in particular).
Subject(s)
Anesthesia, Inhalation , Lymphoma, Non-Hodgkin/pathology , Sarcoma 37/pathology , Sarcoma, Experimental/pathology , Animals , Chloroform/pharmacology , Ether/pharmacology , Halothane/pharmacology , Lymphoma, Non-Hodgkin/surgery , Methoxyflurane/pharmacology , Mice , Mice, Hairless , Mitosis/drug effects , Neoplasm Metastasis , Neuroleptanalgesia , Rats , Sarcoma 37/surgeryABSTRACT
A comparative quantitative investigation on the level of 11-oxycorticosteroids (11-OCS) in the peripheral blood and on morphological changes in the lymphoid tissue has been performed on intact and adrenalectomized rats after 3 hours' ether and halothane anesthesia. Three hours after the ether anesthesia, the level of 11-OCS increases more than twice, halothane is not a stress-producing anesthesia. After the ether anesthesia and essential devastation of the lymphoid tissue occurs, resulted from degeneration and a decreasing proliferative activity of the cells. In the adrenalectomized animals, both after halothane and either anesthesia, there are no essential morphological changes. Thus, certain significant differences between hormonal and morphological changes after either the halothane anesthesia have been revealed, as well as the role of the adrenal cortex in this activity.
Subject(s)
Anesthesia, Inhalation , Ether , Ethyl Ethers , Halothane , Lymphoid Tissue/drug effects , 11-Hydroxycorticosteroids/blood , Adrenal Glands/physiology , Adrenalectomy , Animals , Lymph Nodes/cytology , Lymph Nodes/drug effects , Lymphoid Tissue/cytology , Male , Mitosis/drug effects , Rats , Thymus Gland/cytology , Thymus Gland/drug effectsABSTRACT
The inoculation of sarcoma-37 against the background of the ganglionary blockade, provided by the intraperitoneal injection of 1 ml of pentamine, is not associated with its less take rate, but there is a manifest suppression of the tumor growth during the period up to 63 days. A preliminary ganglionary blockade completely eliminates the stimulating effect of a trauma on the tumor growth.
