ABSTRACT
The results of triple Helicobacter-therapy (omeprazole, amoxicillin, nifuratel) in the treatment of chronic gastroduodenal pathology in children depending on the duration of it's use. The effectiveness of drug therapy was evaluated in terms of eradication of Helicobacter pylori and dynamics of pain, dyspeptic syndrome and astenovegetative syndrome.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Duodenitis/drug therapy , Gastritis/drug therapy , Helicobacter Infections/drug therapy , Helicobacter pylori/drug effects , Pain/prevention & control , Adolescent , Amoxicillin/therapeutic use , Antigens, Bacterial/genetics , Antigens, Bacterial/metabolism , Bacterial Proteins/genetics , Bacterial Proteins/metabolism , Child , Chronic Disease , Drug Administration Schedule , Drug Therapy, Combination , Duodenitis/complications , Duodenitis/microbiology , Duodenitis/physiopathology , Gastritis/complications , Gastritis/microbiology , Gastritis/physiopathology , Gene Expression , Helicobacter Infections/complications , Helicobacter Infections/microbiology , Helicobacter Infections/physiopathology , Helicobacter pylori/genetics , Helicobacter pylori/growth & development , Helicobacter pylori/pathogenicity , Humans , Nifuratel/therapeutic use , Omeprazole/therapeutic use , Pain/complications , Pain/microbiology , Pain/physiopathology , Treatment OutcomeABSTRACT
A high degree of correlation between experimentally established and theoretically calculated constant concentrations of phenazepam was revealed in blood plasma of patients. Due to experimental findings the employment of a single-dose drug administration with regard to previously stated effective-dose interval during dosage build-up made possible estimating the maximum allowable individual dosage which should yield a good therapeutic result without side effects.
Subject(s)
Anti-Anxiety Agents , Benzodiazepines , Benzodiazepinones/blood , Administration, Oral , Adult , Benzodiazepinones/administration & dosage , Half-Life , Humans , Kinetics , Middle Aged , Time FactorsABSTRACT
During learning in a T-maze, rats administered cleregil (150 mg/kg, i.p.) developed a dissociated state where the reflex manifested itself only after the substance injection and did not occur without it. Atropine, amizil, alpha-methyl-DOPA and piracetam were established to be able to replace cleregil, thus restoring the conditioned reflex upset by cleregil withdrawal, as well as to eliminate the manifestations of aggressiveness, fear and anxiety caused by prolonged injection of cleregil. Meanwhile depakin and beta-ethyl-diphacil had no effect on behavioral abnormalities, whereas arecoline made them more demonstrable. It is assumed that M-cholinergic system plays the most important role in the mechanism by which the dissociated state is formed.
Subject(s)
Deanol/pharmacology , Dissociative Disorders/chemically induced , Ethanolamines/pharmacology , Glutamates/pharmacology , Receptors, Cholinergic/drug effects , Amnesia/chemically induced , Animals , Behavior, Animal/drug effects , Conditioning, Classical/drug effects , Drug Combinations/pharmacology , Humans , Male , Rats , Time FactorsABSTRACT
Experiments on animals were made to study pharmacological activity of "atypical" tranquilizers (nitrazepam, flunitrazepam, clobasam, tacitin, clonazepam, depakin) according to the classical methods for determination of pharmacological activity of typical anxiolytics. As regards the spectrum of pharmacological activity, "atypical" tranquilizers differ from classical anxiolytics. The anxiolytic effect exhibited by the latter group drugs with the exception of clonazepam develops in the presence of the sedative manifestations. The data obtained attest to the necessity of a comprehensive methodological approach to the assessment of "atypical" tranquilizers.
Subject(s)
Tranquilizing Agents/pharmacology , Aggression/drug effects , Animals , Anti-Anxiety Agents/pharmacology , Conditioning, Classical/drug effects , Conflict, Psychological , Electric Stimulation , Exploratory Behavior/drug effects , Humans , Male , RatsABSTRACT
The therapeutic effect of 6 benzodiazepine tranquilizers (diazepam, oxazepam, chlordiazepoxide, phenazepam, lorazepam, nitrazepam) was compared to the activity displayed in the most widely used experimental models. The methods of conflict situation, antagonism with thiosemicarbazide and corasole were found to be highly significant for predicting the clinical efficacy of benzodiazepines. The conditioned reflex techniques were shown untenable for estimating the therapeutic action of the tranquilizers. The correlation was discovered between integral clinical tranquilizing effects of benzodiazepines, their experimental activity and affinity to benzodiazepine receptors.
Subject(s)
Anti-Anxiety Agents/pharmacology , Azepines/pharmacology , Polymers/pharmacology , Receptors, Drug/drug effects , Animals , Anti-Anxiety Agents/therapeutic use , Benzodiazepines , Conditioning, Classical/drug effects , Drug Evaluation , Drug Evaluation, Preclinical , Humans , Receptors, GABA-AABSTRACT
Lithium salts were given to 88 patients with chronic alcoholism and affective disorders in the clinical picture (32 of the patients received lithium for more than 3 months). Positive results were seen in those cases where pathology of the affective sphere was marked in the premorbid period of alcoholism and was only aggravated in the formation of alcoholism. The absence of any affect was found in those cases where affective disorders first appeared at the remote stages of alcoholism (II-III and III stages). About in 1/3 of the cases there were side-effects, more frequently in the form of dyspeptical disorders.
