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Ukr Biokhim Zh (1978) ; 69(1): 37-41, 1997.
Article in Russian | MEDLINE | ID: mdl-9454376

ABSTRACT

It has been found that hydroxylated pyrimidine derivatives actively participate in metabolic proceeds related to functioning of vitamin B1-dependent enzymes (transketolase, 2-oxo acid dehydrogenase). Hydroxypyrimidines also induce a significant increase in the levels of total lipids and cholesterol in the mice liver, not changing the phospholipid content.


Subject(s)
Ketoglutarate Dehydrogenase Complex/metabolism , Lipid Metabolism , Pyrimidines/pharmacology , Pyruvate Dehydrogenase Complex/metabolism , Transketolase/metabolism , Animals , Cholesterol/metabolism , Female , Hydroxylation , Mice , Phospholipids/metabolism , Pyrimidines/chemistry
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