ABSTRACT
Showings of studying the life quality with the aid of the SF-36 questionnaire can be used for assessing long-term results of various types of surgeries at complicated duodenal ulcer. Unlike stomach resections, functional surgeries provide a higher life quality of patients. Such differences become more apparent as time after the surgery passes by.
Subject(s)
Duodenal Ulcer/surgery , Quality of Life , Case-Control Studies , Female , Follow-Up Studies , Gastrectomy/methods , Humans , Male , Surveys and Questionnaires , Treatment OutcomeSubject(s)
Digestive System Surgical Procedures/methods , Duodenal Ulcer/surgery , Peptic Ulcer Perforation/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Duodenal Ulcer/complications , Female , Humans , Male , Middle Aged , Peptic Ulcer Perforation/etiology , Peritonitis/etiology , Peritonitis/surgery , Reoperation , Treatment OutcomeABSTRACT
Motor-evacuatory disorders (MED) of the stomach in 114 patients who have undergone functional operations for duodenal ulcers were analyzed. Clinical picture, barium contrast and ultrasonic examinations, fibrogastroduodenoscopy, pH-monitoring were used for evaluation. Many patients have MED of different degree in early postoperative period. Some patients have severe disorders that require drug therapy. US and endoscopy role in complex assessment and differential analysis of stomach evacuatory disorders is emphasized. Isolated elements of study methods are discussed.
Subject(s)
Duodenal Ulcer/surgery , Gastric Emptying , Stomach/physiopathology , Duodenal Ulcer/physiopathology , HumansSubject(s)
Antibodies, Bacterial/blood , Endotoxins/immunology , Glycolipids/immunology , Immunotherapy , Peritonitis/immunology , Combined Modality Therapy , Gram-Negative Bacterial Infections/immunology , Gram-Negative Bacterial Infections/therapy , Humans , Peritonitis/complications , Peritonitis/therapy , Postoperative Period , Sorption Detoxification , Time FactorsABSTRACT
The ultraviolet (UV) irradiation of donor blood plasma with an elevated level of natural antibodies to Re-glycolipid with doses ranging from 100 to 200 J/m2 has been found to lead to a statistically significant rise in its protective activity. The use of such plasma in clinical practice has made it possible to decrease the frequency of lethal outcomes from 24.3% to 16.5% (p < 0.01), the occurrence of secondary infectious complications from 62% to 44.4% (p < 0.01) and the duration of patients' stay in a hospital by 6-8 days. These data make it possible to regard the use of UV-irradiated plasma with an elevated level of Re-antibodies as an effective method of the immunotherapy of septic complications caused by gram-negative bacteria.
Subject(s)
Antibodies, Bacterial/radiation effects , Antibodies, Bacterial/therapeutic use , Blood Donors , Endotoxins/immunology , Peritonitis/therapy , Plasma/immunology , Plasma/radiation effects , Sorption Detoxification/methods , Ultraviolet Therapy , Acute Disease , Adolescent , Adult , Combined Modality Therapy , Female , Glycolipids/immunology , Gram-Negative Bacterial Infections/complications , Gram-Negative Bacterial Infections/immunology , Gram-Negative Bacterial Infections/therapy , Humans , Male , Middle Aged , Peritonitis/complications , Peritonitis/immunologySubject(s)
Antibodies, Bacterial/immunology , Bacterial Vaccines/therapeutic use , Enterobacteriaceae Infections/therapy , Enterobacteriaceae/immunology , Peritonitis/therapy , Bacterial Toxins/adverse effects , Bacterial Vaccines/immunology , Enterobacteriaceae/pathogenicity , Enterobacteriaceae Infections/etiology , Enterobacteriaceae Infections/microbiology , Humans , Immunotherapy/methods , Lipopolysaccharides/adverse effects , Peritonitis/etiology , Peritonitis/microbiologySubject(s)
Endotoxins/blood , Animals , Humans , Ligands , Lipopolysaccharides/blood , Lipoproteins, HDL/blood , Neutrophils/metabolism , Protein Binding , Sepsis/bloodABSTRACT
The article analyzes the possibility of immunotherapy of septic complications in cases of peritonitis caused by gram-negative bacteria. A strictly inverse correlation between the severity of intoxication and the level of antibodies to glycolipid Re in blood serum has been established. About 5% of healthy nonimmunized donors have elevated Re-antibody titers (1:128 and higher) in their blood plasma. Screening of blood preparations from more than 1000 donors permitted the creation of the blood plasma bank used for the treatment of peritonitis patients. Immunotherapy of such patients has made it possible to decrease almost two-fold the death rate and to reduce the severity and duration of the intoxication syndrome in patients, as well as to improve the results of the treatment of peritonitis.
Subject(s)
Antibodies/therapeutic use , Glycolipids/immunology , Peritonitis/therapy , Plasma/immunology , Acute Disease , Antibodies/blood , Bacterial Infections/immunology , Bacterial Infections/therapy , Blood Donors , Blood Transfusion , Combined Modality Therapy , Glycolipids/blood , Gram-Negative Bacteria , Hemagglutination Tests , Humans , Peritonitis/immunology , Plasma/analysis , Postoperative Complications/therapyABSTRACT
The screening of the preparations of blood plasma obtained from 1,608 donors made it possible to establish the presence of high titers of natural antibodies to Re-glycolipid in 3% of the donors. Donor plasma containing antibodies to Re-glycolipid in a titer of 1:128 ensured a high level of protection for mice in experimental fecal peritonitis. The treatment of 10 patients having commonly occurring forms of peritonitis, caused by Gram-negative bacteria, with the use of such plasma yielded a positive clinical effect. The presence of correlation between the titers of antibodies to Re-glycolipid in blood plasma preparations and the content of high-density lipoproteids, expressed in per cent, was noted.
