Tunnel widening after ACL reconstruction with different fixation techniques: aperture fixation with biodegradable interference screws versus all-inside technique with suspensory cortical buttons. 5-year data from a prospective randomized trial.

BACKGROUND: The aim of the present study was to examine tunnel widening and clinical outcomes after anterior cruciate ligament reconstruction (ACLR) using two different fixation methods: aperture fixation with biodegradable interference screws versus all-inside ACLR with suspensory cortical buttons. METHODS: Tunnel widening was assessed using volumetric and diameter measurements on magnetic resonance imaging (MRI) scans directly after surgery, as well as 6 months and 2 and 5 years postoperatively. Clinical outcomes were assessed after 5 years with instrumented tibial anteroposterior translation measurement (KT-1000), single-leg hop testing, and the IKDC, Lysholm, and Tegner activity scores. RESULTS: At the final follow-up, the study population consisted of 21 patients, 12 of whom underwent screw fixation and 9 of whom had button fixation. 3 patients with all-inside ACLR had sustained early repeat ruptures within 6 months after surgery and had to be excluded from the further analysis. With screw fixation, the tibial tunnel volume changed significantly more over time compared to all-inside button fixation, with a larger initial increase at 6 months (from postoperative 2.9 ± 0.2 to 3.3 ± 0.2 cm3 at 6 months versus 1.7 ± 0.1 to 1.9 ± 0.2 cm3) and a greater final decrease over 2-5 years postoperatively (from 3.1 ± 0.2 to 1.9 ± 0.2 cm3 versus 1.8 ± 0.2 ± 0.1 to 1.3 ± 0.1 cm3) (P < 0.001). The femoral tunnel volume remained comparable between the two groups throughout the follow-up period, with an initial 1.6 ± 0.1 cm3 in both groups and 1.2 ± 0.1 vs. 1.3 ± 0.1 after 5 years in the screw and button groups, respectively (P ≥ 0.314). The maximum tibial and femoral tunnel diameters were significantly larger with screw fixation at all four time points. Tibial diameters measured 11.1 ± 0.2, 12.3 ± 0.3, 12.3 ± 0.4, and 11.2 ± 0.4 mm in the screw group versus 8.1 ± 0.3, 8.9 ± 0.3, 9.1 ± 0.4 and 8.2 ± 0.5 mm in the button group (P < 0.001). Femoral diameters measured 8.6 ± 0.2, 10.5 ± 0.4, 10.2 ± 0.3, and 8.9 ± 0.3 versus 7.3 ± 0.3, 8.4 ± 0.4, 8.4 ± 0.3, 7.5 ± 0.3, respectively (P ≤ 0.007). Four patients (33%) in the screw group exceeded a diameter of 12 mm on the tibial side after 5 years versus none in the button group (not significant, P = 0.104). Tibial anteroposterior translation measurement with KT-1000 after 5 years was 2.3 ± 2.4 mm in the screw group versus 3.2 ± 3.5 mm in the button group (not significant, P = 0.602). There were no significant differences between the groups in any of the other clinical outcomes. CONCLUSION: Tibial tunnels in ACLR with screw fixation were associated with a larger increase in tunnel volume within the first 2 years and a greater decrease up to 5 years after surgery, while femoral tunnel volumes did not differ significantly. On the tibial side, the need for staged revision ACLR may be greater after biodegradable interference screw fixation if repeat ruptures occur, especially within the first 2 years after primary ACLR. Concerns may remain regarding a higher graft failure rate with all-inside ACLR. LEVEL OF EVIDENCE: II. RCT CONSORT: NCT01755819.

Time-Synchronized MRI-Assessment of Respiratory Apparatus Subsystems-A Feasibility Study.

The thorax (TH), the thoracic diaphragm (TD), and the abdominal wall (AW) are three sub-systems of the respiratory apparatus whose displacement motion has been well studied with the use of magnetic resonance imaging (MRI). Another sub-system, which has however received less research attention with respect to breathing, is the pelvic floor (PF). In particular, there is no study that has investigated the displacement of all four sub-systems simultaneously. Addressing this issue, it was the purpose of this feasibility study to establish a data acquisition paradigm for time-synchronous quantitative analysis of dynamic MRI data from these four major contributors to respiration and phonation (TH, TD, AW, and PF). Three healthy females were asked to breathe in and out forcefully while being recorded in a 1.5-Tesla whole body MR-scanner. Spanning a sequence of 15.12 seconds, 40 MRI data frames were acquired. Each data frame contained two slices, simultaneously documenting the mid-sagittal (TH, TD, PF) and transversal (AW) planes. The displacement motion of the four anatomical structures of interest was documented using kymographic analysis, resulting in time-varying calibrated structure displacement data. After computing the fundamental frequency of the cyclical breathing motion, the phase offsets of the TH, PF, and AW with respect to the TD were computed. Data analysis revealed three fundamentally different displacement patterns. Total structure displacement was in the range of 0.94 cm (TH) to 4.27 cm (TD). Phase delays of up to 90∘ (i.e., a quarter of a breathing cycle) between different structures were found. Motion offsets in the range of -28.30∘ to 14.90∘ were computed for the PF with respect to the TD. The diversity of results in only three investigated participants suggests a variety of possible breathing strategies, warranting further research.

Breathing, (S)Training and the Pelvic Floor-A Basic Concept.

BACKGROUND: The current scientific literature is inconsistent regarding the potential beneficial or deleterious effects of high-intensity physical activities on the pelvic floor (PF) in women. So far, it has not been established with certainty whether disparate breathing mechanisms may exert short- or long-term influence on the PF function in this context, although based on the established physiological interrelationship of breathing with PF activation, this seems plausible. OBJECTIVE: To propose a basic concept of the influence of different breathing patterns on the PF during strenuous physical efforts. Methodical approaches: Review of the recent literature, basic knowledge of classical western medicine regarding the principles of muscle physiology and the biomechanics of breathing, additional schematic illustrations, and magnetic resonance imaging (MRI) data corroborate the proposed concept and exemplify the consequences of strenuous efforts on the PF in relation to respective breathing phases. CONCLUSION: The pelvic floor muscles (PFMs) physiologically act as expiratory muscles in synergy with the anterolateral abdominal muscles, contracting during expiration and relaxing during inspiration. Obviously, a strenuous physical effort requires an expiratory motor synergy with the PFM and abdominal muscles in a co-contracted status to train the PFM and protect the PF against high intra-abdominal pressure (IAP). Holding breath in an inspiratory pattern during exertion stresses the PF because the high IAP impinges on the relaxed, hence insufficiently protected, PFMs. It seems conceivable that such disadvantageous breathing, if performed regularly and repeatedly, may ultimately cause PF dysfunction. At any rate, future research needs to take into account the respective breathing cycles during measurements and interventions addressing PFM function.

Condylar erosion is predictive of painful closed lock of the temporomandibular joint: a magnetic resonance imaging study.

BACKGROUND: To assess whether magnetic resonance imaging (MRI) findings of condylar erosion (CE) are predictive of a specific clinical diagnosis of painful closed lock of the temporomandibular joint (TMJ), and to determine the strength of association between CE and types of internal derangement (ID). METHODS: Based upon sample size estimation, this retrospective paired-design study involved 62 patients, aged between 18 and 67 years. Inclusion criteria were the presence of a unilateral clinical diagnosis of arthralgia coexisting with disk displacement without reduction ('AR and DDwoR/wLO'), assigned according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) Axis I, and the absence of signs and symptoms of TMJ pain and dysfunction on the contralateral TMJ side. Bilateral sagittal and coronal MR images were obtained to establish the prevalence of CE and TMJ ID types of disk displacement with (DDR) and without reduction (DDNR). Logistic regression analysis was used to compute odds ratios for CE and ID types. Confounding variables adjusted for were age, sex, time since pain onset, pain intensity, and type of ID. RESULTS: In the regression analysis, the MRI items of DDR (p = 0.533) and DDNR (p = 0.204) dropped out as nonsignificant in the diagnostic clinical 'AR and DDwoR/wLO' group. Significant increases in the risk of 'AR and DDwoR' occurred with CE (3.1:1 odds ratio; p = 0.026). The presence of CE was significantly related to DDNR (adjusted OR = 43.9; p <  0.001). CONCLUSIONS: The data suggest CE as a dominant factor in the definition of painful closed lock of the TMJ, support the view that joint locking needs to be considered as a frequent symptom of osteoarthritis, and emphasize a strong association between the MRI items of CE and DDNR.

A logistic analysis prediction model of TMJ condylar erosion in patients with TMJ arthralgia.

BACKGROUND: In terms of diagnostic and therapeutic management, clinicians should adequately address the frequent aspects of temporomandibular joint (TMJ) osteoarthritis (OA) associated with disk displacement. Condylar erosion (CE) is considered an inflammatory subset of OA and is regarded as a sign of progressive OA changes potentially contributing to changes in dentofacial morphology or limited mandibular growth. The purpose of this study was to establish a risk prediction model of CE by a multivariate logistic regression analysis to predict the individual risk of CE in TMJ arthralgia. It was hypothesized that there was a closer association between CE and magnetic resonance imaging (MRI) indicators. METHODS: This retrospective paired-design study enrolled 124 consecutive TMJ pain patients and analyzed the clinical and TMJ-related MRI data in predicting CE. TMJ pain patients were categorized according to the research diagnostic criteria for temporomandibular disorders (RDC/TMD) Axis I protocol. Each patient underwent MRI examination of both TMJs, 1-7 days following clinical examination. RESULTS: In the univariate analysis analyses, 9 influencing factors were related to CE, of which the following 4 as predictors determined the binary multivariate logistic regression model: missing posterior teeth (odds ratio [OR] = 1.42; P = 0.018), RDC/TMD of arthralgia coexistant with disk displacement without reduction with limited opening (DDwoR/wLO) (OR = 3.30, P = 0.007), MRI finding of disk displacement without reduction (OR = 10.96, P < 0.001), and MRI finding of bone marrow edema (OR = 11.97, P < 0.001). The model had statistical significance (chi-square = 148.239, Nagelkerke R square = 0.612, P < 0.001). Out of the TMJs, 83.9% were correctly predicted to be CE cases or Non-CE cases with a sensitivity of 81.4% and a specificity of 85.2%. The area under the receiver operating characteristic curve was 0.916. CONCLUSION: The established prediction model using the risk factors of TMJ arthralgia may be useful for predicting the risk of CE. The data suggest MRI indicators as dominant factors in the definition of CE. Further research is needed to improve the model, and confirm the validity and reliability of the model.

ACL reconstruction with adjustable-length loop cortical button fixation results in less tibial tunnel widening compared with interference screw fixation.

PURPOSE: To compare tunnel widening and clinical outcome after anterior cruciate ligament reconstruction (ACLR) with interference screw fixation and all-inside reconstruction using button fixation. METHODS: Tunnel widening was assessed using tunnel volume and diameter measurements on computed tomography (CT) scans after surgery and 6 months and 2 years later, and compared between the two groups. The clinical outcome was assessed after 2 years with instrumented tibial anteroposterior translation measurements, hop testing and International Knee Documentation Committee (IKDC), Lysholm and Tegner activity scores. RESULTS: The study population at the final follow-up was 14 patients with screw fixation and 16 patients with button fixation. Tibial tunnels with screw fixation showed significantly larger increase in tunnel volume over time (P = 0.021) and larger tunnel diameters after 2 years in comparison with button fixation (P < 0.001). There were no significant differences in femoral tunnel volume changes over time or in tunnel diameters after 2 years. No significant differences were found in the clinical outcome scores. CONCLUSIONS: All-inside ACLR using button fixation was associated with less tibial tunnel widening and smaller tunnels after 2 years in comparison with ACLR using screw fixation. The need for staged revision ACLRs may be greater with interference screws in comparison with button fixation at the tibial tunnel. The clinical outcomes in the two groups were comparable. LEVEL OF EVIDENCE: II. RCT: Consort NCT01755819.

Diagnosing extensor carpi ulnaris tendon dislocation with dynamic rotation MRI of the wrist.

OBJECTIVE: The purpose of this study was to retrospectively correlate the kinematic dynamic rotation MRI (DR-MRI) of the wrist for assessment of extensor carpi ulnaris (ECU) tendon subluxation and dislocation. MATERIAL AND METHODS: The presence of an ECU tendon subluxation or dislocation on the DR-MRI report was correlated to findings of the surgical report. RESULTS: DR-MRI findings showed an ECU subluxation in 12 cases and an ECU dislocation in 13 cases. Surgery showed an ECU subluxation in 13 cases and an ECU dislocation in 12 cases (ĸ = 0.92). CONCLUSION: DR-MRI is a feasible method to visualize ECU tendon subluxation and dislocation.

Assessment of Location of the Mandibular Canal: Correlation Between Panoramic and Cone Beam Computed Tomography Measurements.

PURPOSE: To compare panoramic and cone beam computed tomography (CBCT) determinations of implant-to-mandibular canal (MC) dimensions in mandibular regions posterior to the mental foramen and to investigate whether factors such as gender, age, region, and vertical dimension influence correlation between the two techniques. MATERIALS AND METHODS: A retrospective analysis was carried out in 64 consecutive adult patients (42 females, 22 males; average age 57.1 ± 13.3 years) in whom 126 implants were positioned in the posterior segment of the mandible. Implant sites (first premolar, second premolar, first molar, and second molar) were assessed on each panoramic and CBCT radiograph by measuring the distance from the inferior border of the implant to the superior border of the MC. Binary logistic regression analysis was used to compute the odds ratios (ORs) of each implant site for underestimation vs nonunderestimation. Linear regression analysis was performed with CBCT dimension as the dependent variable and panoramic dimension, gender, and age as the independent variables. RESULTS: The mean implant-to-MC dimension was 2.50 ± 1.31 mm in panoramic radiography and 2.91 ± 1.62 mm in CBCT. The OR that an implant at the second molar region belonged to the underestimation group was strong (15.1:1) and highly significant (P = .011). If a predictive value of .95 was demanded, the implant-to-MC dimensions had to be overestimated by 2 mm compared to the predicted CBCT dimension. CONCLUSION: This study provides evidence of an underestimation of available vertical bone dimensions for implants in the posterior regions of the mandible when assessed by panoramic radiography. Use of CBCT is therefore recommended for all implant size estimations in this region.

Association Between Missing Posterior Teeth and Occurrence of Temporomandibular Joint Condylar Erosion: A Cone Beam Computed Tomography Study.

PURPOSE: To determine a possible association between asymptomatic temporomandibular joint (TMJ) condylar erosion and the number of missing posterior teeth and their location, as well as the number of dental quadrants with missing posterior teeth. MATERIALS AND METHODS: This case-control study involved 210 patients (male to female ratio = 98:112) aged 16-74 years, with 105 asymptomatic patients with TMJ condylar erosion and a control group of 105 patients without TMJ condylar erosion. Cone beam computed tomography images were evaluated to classify the severity of TMJ condylar erosion as grade 0 (absence of erosion), grade I (slight erosion), grade II (moderate erosion), or grade III (extensive erosion). RESULTS: The number of missing posterior teeth (mean ± standard deviation [SD]; 2.7 ± 2.4 vs 0.7 ± 1.2) (P < .001), number of dental quadrants with missing posterior teeth (1.5 ± 1.3 vs 0.6 ± 0.9) (P < .001), and bilateral location of missing posterior teeth (41 ± 39.0 vs 10 ± 9.5) (P < .001) were all significantly higher in patients with erosion than in those without erosion. The condylar erosion grade was significantly associated with the number of missing posterior teeth (odds ratio [OR] = 1.24; P = .006), the number of dental quadrants with missing posterior teeth (OR = 1.36; P = .006), and the bilateral occurrence of missing posterior teeth (OR = 3.03; P = .002). CONCLUSION: The findings from this study suggest a possible association between TMJ condylar erosion grades and the number of missing posterior teeth, the number of quadrants with missing posterior teeth, and the bilateral occurrence of missing posterior teeth.

Tunnel widening after ACL reconstruction with aperture screw fixation or all-inside reconstruction with suspensory cortical button fixation: Volumetric measurements on CT and MRI scans.

BACKGROUND: Tunnel widening after anterior cruciate ligament reconstruction (ACLR) is influenced by the surgical and fixation techniques used. Computed tomography (CT) is the most accurate image modality for assessing tunnel widening, but magnetic resonance imaging (MRI) might also be reliable for tunnel volume measurements. In the present study tunnel widening after ACLR using biodegradable interference screw fixation was compared with all-inside ACLR using button fixation, with tunnel volume changes being measured on CT and MRI scans. STUDY DESIGN: Randomized controlled trial; Level of evidence, 2. METHODS: Thirty-three patients were randomly assigned to hamstring ACLR using a biodegradable interference screw or all-inside cortical button fixation. CT and MRI scanning were done at the time of surgery and six months after. Tunnel volume changes were calculated and compared. RESULTS: On CT, femoral tunnel volumes changed from the postoperative state (100%) to 119.8% with screw fixation and 143.2% with button fixation (P=0.023). The changes in tibial tunnel volumes were not significant (113.9% vs. 117.7%). The changes in bone tunnel volume measured on MRI were comparable with those on CT only for tunnels with interference screws. Tibial tunnels with button fixation were significantly underestimated on MRI scanning (P=0.018). CONCLUSIONS: All-inside ACLR using cortical button fixation results in increased femoral tunnel widening in comparison with ACLR with biodegradable interference screw fixation. MRI represents a reliable imaging modality for future studies investigating tunnel widening with interference screw fixation.

Condylar Erosion in Patients With Chronic Temporomandibular Joint Arthralgia: A Cone-Beam Computed Tomography Study.

PURPOSE: The objective of this study was to assess the association between temporomandibular joint (TMJ) condylar erosion and chronic TMJ arthralgia. MATERIALS AND METHODS: Based on a sample size estimation, this case-and-control study involved 198 patients 16 to 73 years old recruited from a routine clinical practice (99 cases, patients with chronic TMJ arthralgia and mean pain duration of 16.4 months; 99 controls, asymptomatic patients without a history of orofacial pain). The clinical diagnosis of arthralgia was made according to the Research Diagnostic Criteria for Temporomandibular Disorders. Cone-beam computed tomographic (CBCT) images were evaluated for the presence or absence of erosive osseous changes of the TMJ condyle. Severity of TMJ condylar erosion was classified as grade 0 (absence of erosion), grade I (slight erosion), grade II (moderate erosion), or grade III (extensive erosion). Logistic regression analysis was used to assess the association between chronic TMJ arthralgia and condylar erosion, adjusting for age, gender, number of missing posterior teeth, and number of dental quadrants with missing posterior teeth. RESULTS: TMJ condylar erosion was found in 59.6% of cases and 21.2% of controls. There was a significant association between TMJ arthralgia and degree of condylar erosion (P < .001). The odds ratio that a TMJ with condylar erosion grade II might belong to the TMJ arthralgia group was strong (3.1:1; 95% confidence interval [CI], 1.17 to 8.09) and significant (P = .023). Significant increases in risk of TMJ arthralgia occurred with condylar erosion grade III (7.7:1; 95% CI, 3.09 to 19.18; P < .001). CONCLUSIONS: The study provides evidence of an association between TMJ condylar erosion and chronic TMJ arthralgia.

Proof of concept: differential effects of Valsalva and straining maneuvers on the pelvic floor.

OBJECTIVE: To prove a basic physiological principle in healthy women, demonstrating different movement patterns of diaphragm, pelvic floor, and muscular wall surrounding the abdominal cavity during a Valsalva maneuver as opposed to a straining maneuver, by means of real-time dynamic magnetic resonance imaging (MRI). STUDY DESIGN: The study was performed at Hochzirl Hospital, Austria and Department of Radiology, Medical University Innsbruck, Austria. Four healthy women underwent MRI measurements in a 1.5-T whole body MR-scanner. Coronal, sagittal, and axial slices were acquired simultaneously and a dynamic MRI sequence was used to assess cranio-caudal movements of the diaphragm and pelvic floor and of concomitant changes in anterolateral abdominal muscle thickness and abdominal diameter at the umbilical level. RESULTS: Both the Valsalva maneuver and the straining maneuver began with deep inspiration and downward movement of the diaphragm. During the exertion phase of both maneuvers, abdominal muscle thickness increased and abdominal diameter decreased. During the Valsalva maneuver, the pelvic floor moved cranially parallel to the diaphragm, whereas during the straining maneuver, the pelvic floor was markedly displaced caudally. CONCLUSION: The Valsalva maneuver reflects an expiratory pattern with diaphragm and pelvic floor elevation, whereas during straining the pelvic floor descends.

Cephalometric variables discriminate among magnetic resonance imaging-based structural characteristic groups of the temporomandibular joint.

OBJECTIVE: The aim of this study was to assess retrospectively whether, in patients with temporomandibular joint (TMJ) arthralgia, commonly used cephalometric variables of dentofacial morphology can discriminate among magnetic resonanace imaging (MRI)-based TMJ structural characteristic groups of "uni- or bilateral disc displacement without reduction (DDwoR) associated with bilateral osteoarthrosis (OA)" and "uni- or bilateral disc displacement with reduction (DDwR) without OA." STUDY DESIGN: Bilateral MRI of the TMJ was performed in 56 consecutive TMJ arthralgia patients to identify individuals with specific structural characteristic of uni- or bilateral TMJ DDwoR, DDwR, and OA. Application of the criteria resulted in a study group of 31 patients with "uni- or bilateral DDwoR with bilateral OA" and 25 with "uni- or bilateral DDwR without OA." Linear and angular cephalometric measurements were taken from lateral cephalograms to apply selected criteria of dentofacial morphology. One-way analysis of variance was used to assess differences in cephalometric variables by MRI-based TMJ group. Then, discriminant function analysis predicted TMJ group membership. RESULTS: A-B plane to facial plane angle, palatal plane to occlual plane, and interincisal angle produced a significantly discriminant function that predicted TMJ group membership (P < .001). This function correctly classified 85.7% of original grouped cases. CONCLUSIONS: Cephalometric variables may discriminate among MRI-based TMJ structural characteristic groups. Additional diagnostic information related to MRI-based classification groups was generated.

Structural characteristics of bilateral temporomandibular joint disc displacement without reduction and osteoarthrosis are important determinants of horizontal mandibular and vertical ramus deficiency: a magnetic resonance imaging study.

PURPOSE: To estimate in patients with temporomandibular joint (TMJ) arthralgia whether magnetic resonance (MR) imaging findings of bilateral TMJ disc displacement without reduction (DDwoR) and/or osteoarthrosis (OA) are determinants of horizontal mandibular and vertical ramus deficiencies. PATIENTS AND METHODS: Bilateral MR imaging of the TMJ was performed in 68 consecutive patients with TMJ arthralgia to identify those with bilateral TMJ DDwoR and/or OA. Linear and angular cephalometric measurements were performed to apply selected criteria of horizontal mandibular (gonion-menton [Go-Me] <73 mm and articulare-pogonion [Ar-Pog] <105 mm) and vertical ramus (articulare-gonion [Ar-Go] <45 mm) deficiencies. Logistic regression analysis was used to estimate the association between selected MR imaging and cephalometric parameters. RESULTS: In the age- and gender-adjusted analysis, significant increases in the risk of horizontal mandibular (odds ratio, 7.5:1; P = .031) and vertical ramus (odds ratio, 9.5:1; P = .003) deficiencies occurred with bilateral DDwoR and OA. CONCLUSION: In patients with TMJ arthralgia, the MR imaging parameters of DDwoR and OA seem important determinants of horizontal mandibular and vertical ramus deficiencies.

Are temporomandibular joint disk displacements without reduction and osteoarthrosis important determinants of mandibular backward positioning and clockwise rotation?

OBJECTIVE: The aim of this study was to estimate whether, in patients with temporomandibular joint (TMJ) arthralgia, the magnetic resonanace imaging (MRI) findings of bilateral TMJ disk displacement without reduction (DDwoR) and/or osteoarthrosis (OA) are determinants of mandibular backward positioning and/or clockwise rotation. STUDY DESIGN: Bilateral MRI of the TMJ was performed in 50 consecutive TMJ arthralgia patients to identify individuals with bilateral TMJ DDwoR and/or OA. Linear and angular cephalometric measurements were taken to apply selected criteria of mandibular backward positioning (FH to Na-Pog <84°, Na-A-Pog >5°, and SNB <75°) and clockwise rotation (FH to OP >13°, MP to FH >35°, and S-Gn to FH >64°). Logistic regression analysis was used to estimate the association between selected MRI and cephalometric parameters. RESULTS: In the age- and gender-adjusted analyses, significant increases in risk of mandibular backward positioning and clockwise rotation occurred with bilateral DDwoR and OA (9.5:1; P = .040). CONCLUSION: In patients with TMJ arthralgia the MRI parameters of DDwoR and OA seem to be important determinants of mandibular backward positioning and clockwise rotation.

Phase-locked parallel movement of diaphragm and pelvic floor during breathing and coughing-a dynamic MRI investigation in healthy females.

INTRODUCTION AND HYPOTHESIS: the aim of this pilot study was to demonstrate physiological movements of the muscular walls surrounding the abdominal cavity during breathing and coughing in healthy nulliparous women by means of real-time dynamic magnetic resonance imaging (MRI). METHODS: eight volunteers underwent MRI measurements in a 1.5-T whole body MR-scanner. Coronal and sagittal slices were acquired simultaneously to assess respiratory-related cranio-caudal movement of diaphragm and pelvic floor (PF) and concomitant changes in horizontal abdominal diameter. RESULTS: respective mean amplitudes of cranio-caudal movement of the right and left diaphragmatic cupolae were 15 ± 6 and 9 ± 7 mm during quiet breathing; 32 ± 15 and 28 ± 16 mm during forceful breathing; and 32 ± 13 and 28 ± 7 mm during coughing. Both diaphragm and PF moved caudally during inspiration and cranially during expiration. Abdominal diameter decreased in all eight women consistently during the expiration phase of breathing, and in five women during coughing. CONCLUSIONS: in healthy women, real-time dynamic MRI demonstrates parallel cranio-caudal movement of the diaphragm and the PF during breathing and coughing and synchronous changes in abdominal wall diameter.

Likelihood ratio methodology to identify predictors of treatment outcome in temporomandibular joint arthralgia patients.

OBJECTIVES: The purpose of this prospective, cohort study of patients with temporomandibular joint (TMJ) pain was to develop rules to predict treatment outcome related to occlusal stabilization splints. STUDY DESIGN: The study comprised 119 patients with a unilateral Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) axis I diagnosis of arthralgia. Visual analog scale (VAS) pain level of function was assessed before stabilization splint therapy and compared with the respective 2-month and 6-month follow-up findings. Magnetic resonance (MR) images were obtained immediately before treatment to establish the presence or absence of disk displacement, osteoarthrosis, effusion, and bone marrow edema. Treatment outcome (success or failure) was categorized based on changes in the VAS pain level after 6 months. RESULTS: Sixty-five (55%) subjects were categorized as treatment success, 17 (14%) as treatment failures, and 37 (31%) as somewhat improved. After using univariate analyis to determine the association between potential clinical and MR imaging predictor variables and treatment outcome status, preliminary prediction rules were developed for prediction of success (positive LR, 10.8; 95% confidence interval [CI], 0.6-188.1) and failure (negative LR, 0.05; CI, 0.0-0.8). The most important variables were time since pain onset, basic VAS pain level, change in VAS level at 2-month follow-up, and clinical diagnoses of disk displacement with and without reduction. CONCLUSION: Outcome following use of occlusal stabilization splints may be predicted from variables collected from self-report and physical examination. Predictive modeling may provide clinicians with the opportunity to identify "at-risk" patients early and initiate alternative treatment approaches.

Dynamic T(1) mapping predicts outcome of chemoradiation therapy in primary rectal carcinoma: sequence implementation and data analysis.

PURPOSE: To describe details about the implementation of a dynamic T(1)-mapping technique and a simple data analysis strategy that can be used to predict therapy outcome in primary rectal carcinoma and to investigate the physiologic meaning of the obtained parameter. MATERIALS AND METHODS: Contrast-enhanced dynamic T(1) mapping was achieved with a snapshot fast low-angle shot (FLASH) T(1) mapping sequence implemented on a 1.5 T MR scanner. This method was applied to 58 patients with primary rectal cancer before onset of chemoradiation therapy. A simple data analysis strategy based on the calculation of the maximum slope of the tissue concentration-time curve divided by the maximum of the arterial input function (AIF) was used as a measure of tumor microcirculation (PI values). RESULTS: The snapshot FLASH (SFL) T(1)-mapping technique is accurate and sensitive enough to detect inhomogeneous uptake kinetics within tumor tissue. Classifying the patients into two groups according to therapy response showed lower mean PI values for responders as compared to nonresponders. PI was found to combine information about permeability surface area product (PS) and blood volume. CONCLUSIONS: The described method based on dynamic T(1) mapping has the potential to be a clinical tool for predicting therapy outcome of preoperative chemoradiation in patients with primary rectal carcinoma.

Magnetic resonance imaging findings of temporomandibular joint soft tissue changes in type V and VI condylar injuries.

PURPOSE: The objective of this study was to describe the incidence of acute temporomandibular joint (TMJ) soft tissue lesions associated with the occurrence of type V (high condylar fractures with dislocation) and type VI condylar fractures (condylar head fractures). PATIENTS AND METHODS: The study comprised 11 consecutive patients, who were assigned a diagnosis of a uni- or bilateral type V or type VI condylar fracture. Bilateral sagittal and coronal magnetic resonance (MR) images were obtained immediately after injury to establish the presence or absence of disc disruption, capsular tear, retrodiskal tissue tear, and hemarthrosis. RESULTS: There was 1 condylar fracture site showing signs of disc disruption (16.7%). Tears in the capsule and retrodiscal tissue were found with an incidence of 77% and 71%, respectively, while the incidence of hemarthrosis accounted for 100%. MR imaging failed to show any signs of soft tissue lesions for condylar nonfracture sites. CONCLUSIONS: Type V and type VI condylar fracture sites are associated with a high incidence of injuries to the joint capsule and retrodiscal tissue. Investigation of longitudinal evidence, including risk factors, natural history, and response to treatment appears warranted and necessary.

3D-MRI rendering of the anatomical structures related to acupuncture points of the Dai mai, Yin qiao mai and Yang qiao mai meridians within the context of the WOMED concept of lateral tension: implications for musculoskeletal disease.

BACKGROUND: A conceptual model of lateral muscular tension in patients presenting thyroid associated ophthalmopathy (TAO) has been recently described. Clinical improvement has been achieved by using acupuncture on points belonging to the so-called extraordinary meridians. The aim of this study was to characterize the anatomical structures related to these acupuncture points by means of 3D MRI image rendering relying on external markers. METHODS: The investigation was carried out the index case patient of the lateral tension model. A licensed medical acupuncture practitioner located the following acupuncture points: 1) Yin qiao mai meridian (medial ankle): Kidney 3, Kidney 6, the plantar Kidney 6 (Nan jing description); 2) Yang qiao mai meridian (lateral ankle): Bladder 62, Bladder 59, Bladder 61, and the plantar Bladder 62 (Nan jing description); 3) Dai mai meridian (wait): Liver 13, Gall bladder 26, Gall bladder 27, Gall bladder 28, and Gall bladder 29. The points were marked by taping a nitro-glycerin capsule on the skin. Imaging was done on a Siemens Magnetom Avanto MR scanner using an array head and body coil. Mainly T1-weighted imaging sequences, as routinely used for patient exams, were used to obtain multi-slice images. The image data were rendered in 3D modus using dedicated software (Leonardo, Siemens). RESULTS: Points of the Dai mai meridian--at the level of the waist--corresponded to the obliquus externus abdominis and the obliquus internus abdominis. Points of the Yin qiao mai meridian--at the medial side of the ankle--corresponded to tendinous structures of the flexor digitorum longus as well as to muscular structures of the abductor hallucis on the foot sole. Points of the Yang qiao mai meridian--at the lateral side of the ankle--corresponded to tendinous structures of the peroneus brevis, the peroneous longus, and the lateral surface of the calcaneus and close to the foot sole to the abductor digiti minimi. CONCLUSION: This non-invasive MRI investigation has revealed the anatomical relations of acupuncture points belonging to 3 of the so-called extraordinary meridians. We conclude that the clinically developed "WOMED concept of lateral tension" is related to tendino-muscular structures.