Subject(s)
Blood Vessels/radiation effects , Acetylcholine/pharmacology , Animals , Blood Vessels/drug effects , Blood Vessels/metabolism , Calcimycin/pharmacology , Free Radicals , Malondialdehyde/blood , Malondialdehyde/metabolism , Nitroglycerin/pharmacology , Norepinephrine/pharmacology , RabbitsABSTRACT
Ultrastructural changes of myocardium cells, neurons of sensorimotor cerebral cortex, endothelium of blood microvessels were registered by transmissive electron microscopy in mice receiving rock balm preparations per os. Both stimulating and toxic effects were observed dependently on used concentrations. This necessitates dosage to be strictly observed.
Subject(s)
Heart/drug effects , Motor Cortex/drug effects , Myocardium/ultrastructure , Resins, Plant/pharmacology , Animals , Dose-Response Relationship, Drug , Heart Ventricles/drug effects , Heart Ventricles/ultrastructure , Humic Substances , Male , Mice , Microscopy, Electron , Minerals , Motor Cortex/ultrastructure , Resins, Plant/toxicity , Stimulation, ChemicalSubject(s)
Endothelium, Vascular/radiation effects , Acetylcholine/pharmacology , Animals , Endothelium, Vascular/drug effects , Endothelium, Vascular/physiology , In Vitro Techniques , Isoproterenol/pharmacology , Muscle Contraction/radiation effects , Nitroglycerin/pharmacology , Norepinephrine/pharmacology , RabbitsABSTRACT
Dynamics of the conditioned behaviour of rats in a shuttle box was studied after combined exposure to Cs-gamma radiation (1 Gy, 1.32 Gy/min) and microwave radiation (2450 MHz, 1 mW/cm2, 3 h). The number of conditioned and interstimulus responses was found to decrease on day 5 after microwave + gamma irradiation and to increase on day 30 after gamma + microwave irradiation.
Subject(s)
Behavior, Animal/radiation effects , Conditioning, Classical/radiation effects , Microwaves , Animals , Gamma Rays , Male , Memory, Short-Term/radiation effects , Rats , Time FactorsABSTRACT
Literature data during 1980-1989 and own studies carried out at the Institute of Experimental Radiology, All-Union Research Center of Radiation Medicine, USSR AMS, summarized in the paper, describe three types of biological responses (increase, decrease and no response) to low-level ionizing radiation up to 100 Rem. It is shown that pathological changes in the biosystems exposed to radiation are detectable with sensitive techniques, the responses are phasic in nature and depend on the input information signal that causes energy redistribution and changes in the living system response.
Subject(s)
Accidents , Nuclear Reactors , Radiation Dosage , Radiation Effects , Adult , Child , Humans , Radiation, Ionizing , Time Factors , UkraineSubject(s)
Academies and Institutes , Accidents , Nuclear Reactors , Radiation Injuries , Radiobiology , Acute Disease , Animals , Child , Humans , Radiation Injuries/genetics , Radiation Injuries/immunology , Radiation Injuries, Experimental/genetics , Radiation Injuries, Experimental/immunology , Research , USSR , UkraineABSTRACT
The polarographic method permitted to register changes in the protein higher structure at radiation doses of the order of tenths Gy. A technique is proposed and optimum conditions found for taking measurements in mammalian serum and plasma in vitro. It is suggested that the proposed technique, having been tested on experimental animals, might be used for an indirect diagnosis of radiation affection in human beings.
Subject(s)
Polarography/methods , Radiation Injuries, Experimental/diagnosis , Animals , Cattle , Dose-Response Relationship, Radiation , Gamma Rays , Radiation Injuries, Experimental/blood , Rats , Serum Albumin/analysis , Serum Albumin/radiation effects , Serum Albumin, Bovine/analysis , Serum Albumin, Bovine/radiation effectsSubject(s)
Brain/radiation effects , Electromagnetic Fields , Electromagnetic Phenomena , Escape Reaction/radiation effects , Microwaves , Models, Biological , Sodium-Potassium-Exchanging ATPase/radiation effects , Synaptosomes/radiation effects , Animals , Brain/physiology , Brain/ultrastructure , Escape Reaction/physiology , International Cooperation , Male , North Carolina , Rats , Rats, Inbred F344 , Sodium-Potassium-Exchanging ATPase/metabolism , Synaptosomes/enzymology , USSRABSTRACT
During the course of a formal program of cooperation between the United States and the Soviet Union concerning the biological effects of physical factors in the environment, it was concluded that duplicate projects should be initiated with the general goal of determining the most sensitive and valid test procedures for evaluating the effects of microwave radiation on the central nervous system. This report details an initial step in this direction. Male rats of the Fischer 344 strain were exposed or sham exposed to 10 mW/cm2 continuous wave microwave radiation at 2.45 GHz for a period of 7 hr. Animals were subjected to behavioral, biochemical, or electrophysiological measurements during and/or immediately after exposure. Behavioral tests used were passive avoidance and activity in an open field. Biochemical measurements were ATPase (Na+, K+; Mg2+, Ca2+) and K+ alkaline phosphatase activities. Electrophysiological measurements consisted of EEG frequency analysis. Neither group observed a significant effect of microwave irradiation on open field activity. Both groups observed changes in variability of the data obtained using the passive avoidance procedure, but not in the same parameters. The U.S. group, but not the USSR group, found significantly less Na+,K+-ATPase activity in the microwave-exposed animals compared to the sham exposed animals. Both groups found incidences of statistically significant effects in the power spectral analysis of EEG frequency, but not at the same frequency. The failure of both groups to substantiate the results of the other reinforces our contention that such duplicate projects are important and necessary.
Subject(s)
Brain/radiation effects , Microwaves/adverse effects , Adenosine Triphosphatases/radiation effects , Animals , Behavior, Animal/radiation effects , Brain/enzymology , Electroencephalography , International Cooperation , Male , Rats , Rats, Inbred F344 , USSR , United StatesABSTRACT
DNA content of nondifferentiated and blast bone marrow cells was studied cytophotometrically after single exposure to SHF-radiation. It is supposed that cell adaptive reactions in blood system are responsible for phase changes in DNA quantity, the passage of cells through the mitotic cycle and their proliferative activity.
Subject(s)
Bone Marrow/radiation effects , DNA/radiation effects , Microwaves/adverse effects , Animals , Bone Marrow Cells , Cell Cycle/radiation effects , Cytophotometry , Male , Mitosis/radiation effects , Rats , Rats, Inbred Strains , Time FactorsABSTRACT
A study was made of morphological composition of blood leukocytes, phagocytic activity, glycogen and alkaline phosphatase content of neutrophils of animals exposed to microwaves of low intensity (1-500 mu W/cm2) generated continuously (2375 MHz) and by impulses (9400 MHz). The direction of the change in these indices and rate of the postirradiation recovery was shown to depend upon intensity and duration (30-120 days) of exposure. The response of albino rats and guinea pigs to the effect of microwaves was different. The effect of microwaves of the intensities under study on the mammalian organism was assessed.