ABSTRACT
The analysis of the literature on communication of a hemostasis and vitamin C has allowed to assert, that its deficiency accelerates lipid peroxidation and reduces potential at porpoises, and it conducts to activation platelets, to acceleration of continuous intravascular blood coagulation of and to reduction in tolerance to thrombin. High dozes of vitamin C influences a hemostasis strengthens lipid peroxidation similarly to prooxidizers. Entering high dozes of vitamin C at the statuses menacing weith thromboses, it is desirable to supervise a level of markers of intravascular blood coagulation in plasma.
Subject(s)
Ascorbic Acid/metabolism , Blood Coagulation/physiology , Blood Platelets/metabolism , Homeostasis , Lipid Peroxidation/physiology , Platelet Activation/physiology , Animals , Ascorbic Acid/administration & dosage , Ascorbic Acid/adverse effects , Ascorbic Acid Deficiency/metabolism , Blood Coagulation/drug effects , Disseminated Intravascular Coagulation/chemically induced , Disseminated Intravascular Coagulation/metabolism , Humans , Lipid Peroxidation/drug effects , Platelet Activation/drug effects , Thrombin/metabolism , Thrombosis/chemically induced , Thrombosis/metabolismABSTRACT
Investigation of 213 rats has shown that exposition containing normal plasma of erythrocytes, neutrophils or monocytes (physiological concentration) taken from the rats treated with prooxidant (lead acetate) or antioxidant (selmevite) causes corresponding increase or decrease of: a) both spontaneous aggregation and ATP-induced aggregation of thrombocytes, b) releasing P3 and P4 factors, c) their lipoperoxidation (LPO) intensity. The effect is released by LPO products released by erythrocytes and leucocytes into their environment. The efficacy of antioxidants (vitamins with antioxidant properties in particular) used for correcting hypercoagulative changes in oxidative stress in clinics is supposed to be due to their capacity for limiting lipidoxidation in erythrocytes, leukocytes and thrombocytes.
Subject(s)
Erythrocytes/metabolism , Homeostasis/drug effects , Lipid Peroxidation/drug effects , Monocytes/metabolism , Neutrophils/metabolism , Adenosine Diphosphate/pharmacology , Animals , Antioxidants/pharmacology , Blood Platelets/metabolism , Organometallic Compounds/pharmacology , Organophosphorus Compounds/pharmacology , Platelet Aggregation/drug effects , RatsABSTRACT
Experiments on a group of 308 rats showed that prooxidant (lead acetate) introduced per os with daily meals decreases the antioxidant potential (increases lipid peroxidation, LPO) and reduces tolerance with respect to thrombin (increases the level of intravascular blood coagulation markers). For the same treatment on the background of a vitamin - antioxidants preparations (complivit or selmevit), the level of changes was significantly decreased and the resistance to thrombin was increased. Selmevit (containing selenium) was more effective. It is concluded that complex vitamin--antioxidants preparations can be used for correcting hemostatic changes in cases of hyperoxidation.
