[Pathomorphological and morphometric evaluation of a model of aortic insufficiency in rabbits treated with taurine]. / Patomorfologicheskaia i morfometricheskaia otsenka modeli aortal'noi nedostatochnosti u krolikov pri lechenii taurinom.

In 45 experimental rabbits, subjected to trans-carotid aorto-valvulotomy in a month developed a congestive heart failure. When this group of rabbits was compared to the control group of 20 animals, in the course of complete pathomorphologic, histochemical and stereomorphologic analysis the following results were obtained: potassium oroticum did not show any efficacy at all; the efficacy of taurine in a dose of 10 mg/kg was low. Its effect was both direct and indirect acting through the autonomic nervous system.

[Pathomorphological criteria of anti-atherosclerotic effect of plant saponins in an experiment]. / Patomorfologicheskie kriterii antiateroskleroticheskogo deistviia saponinov rastitel'nogo proiskhozhdeniia v éksperimente.

6-month hypercholesterol diet made it possible to obtain an adequate model of atherosclerosis in inbred rats. The model was characterized by lipoidosis and fibrous plaques which occupied half of the area of the aorta and coronary arteries, as well as secondary fibrosis of other organs. During atherogenesis changes in endothelial and myocyte cells appear, accumulation of acid glycosaminoglycans takes place, lipoidosis and elastofibrosis progress up to collagenization and hyalinosis of the arterial wall. Fibro-myocyte plaques are transformed into fibro-atheromatous plaques. Upon drug therapy with vegetative saponins and furastonolic glycosides fibrous lesions did not regress, but delipidization and translocation of glycosaminoglycans were observed in 30% of the area of the affected arteries, and elastofibrosis and changes in endothelial and myocyte cells were decreased. Long-term therapy with vegetative drugs produced a regression of the experimental atherosclerosis.