[The level of RANTES and interleukin-8 in serum of children with bronchial asthma after an exercise test]. / Poziom RANTES i interleukiny-8 w surowicy dzieci chorych na astme oskrzelowa podddanych testowi wysilkowemu.

The study was carried out on 20 children with bronchial asthma. After the exercise induced test we observed decreased serum level of RANTES both in children with positive and negative results of the test. Serum level of IL-8 was increased in all examined group. We found strong correlation between serum level of RANTES and peripheral blood eosinophil counts in children with positive result of the test before and after the exercise.

[Preliminary evaluation of efficacy for the preparation DNCG-compositum in treatment of atopic bronchial asthma in children]. / Wstepna ocena skutecznosci preparatu DNCG-compositum w leczeniu atopowej astmy oskrzelowej u dzieci.

Preparations, in which composition disodium cromoglycate goes into, have been for many years the admitted way of bronchial asthma treatment. The introduction, to the therapy, of preparation that contains reproterol as well makes possible the early remission of disease symptoms. The aim of the study was the estimation of the effectiveness of DNCG-comp. preparation. Twenty one children, aged 7-17 years, with recognized bronchial asthma were examined. The atopic basis of the disease was found on the ground of results of skin prick tests, and elevated concentration of serum IgE and positive atopic family interview. We resigned the hitherto treatment for 3 days, carried out the spirometric measurements (PEF, FEV1, FEV1%VC, MEF25,50,75). DNCG-comp. was given 4-times per twenty-four hours in 2 inhalations at each time, for three weeks. Every day, the PEF value and the score of disease symptoms were established. After the study, side effects were not observed and final results of spirometric estimation evidence the possibility of wide application of DNCG-comp. preparation in the treatment of bronchial asthma in childhood.