Synthesis of Five-Membered exo-Glycals from Six-Membered 2-Iodo-endo-glycals.

Five-membered exo-glycals were synthesized from six-membered 2-iodo-endo-glycals by a metal/halogen exchange/ring-opening sequence followed by a cyclization catalyzed by Ag2CO3.

Incorporation of a cyclobutyl substituent in molecules by transition metal-catalyzed cross-coupling reactions.

In this review, the incorporation of a cyclobutyl substituent in molecules, by transition metal-catalyzed cross-coupling, is described by only considering the formation of C-C bonds. Three main strategies are used to introduce a cyclobutyl substituent in molecules by involving either electrophilic or nucleophilic cyclobutane derivatives.