Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Schweiz Arch Tierheilkd ; 155(2): 135-42, 2013 Feb.
Article in German | MEDLINE | ID: mdl-23385072

ABSTRACT

Melanoma is the most common oral tumor in dogs, characterized by rapid growth, local invasion, and high metastatic rate. The goal of this study was to evaluate the combination of radiation therapy and DNA tumor vaccine. We hypothesized, that the concurrent use would not increase toxicity. Nine dogs with oral melanoma were treated with 4 fractions of 8 Gray at 7-day intervals. The vaccine was given 4 times every 14 days, beginning at the first radiation fraction. Local acute radiation toxicities were assessed according to the VRTOG toxicity scoring scheme over a time period of 7 weeks. In none of the evaluated dogs, mucositis, dermatitis and conjunctivitis exceeded grade 2. In 3 dogs mild fever, lethargy, and local swelling at the injection site were seen after vaccine application. In conclusion, the concurrent administration of radiation therapy and vaccine was well tolerated in all dogs.


Subject(s)
Cancer Vaccines/therapeutic use , Dog Diseases/therapy , Melanoma/veterinary , Mouth Neoplasms/veterinary , Vaccines, DNA/therapeutic use , Animals , Combined Modality Therapy/veterinary , Dog Diseases/radiotherapy , Dogs , Female , Male , Melanoma/radiotherapy , Melanoma/therapy , Mouth Neoplasms/radiotherapy , Mouth Neoplasms/therapy , Pilot Projects
2.
Schweiz Arch Tierheilkd ; 153(8): 351-60, 2011 Aug.
Article in German | MEDLINE | ID: mdl-21780063

ABSTRACT

In human oncology, novel targeted therapy focusing on monoclonal antibodies and tyrosine kinase inhibitors has become an attractive anticancer strategy. The introduction of antiangiogenetic drugs and metronomic chemotherapy has also increased the therapeutic arsenal. Chemotherapy still plays a key role in the treatment of many tumors affecting dogs and cats. However, novel anticancer strategies (including tyrosine kinase inhibitors and monoclonal antibodies, as well as antiangiogenetic treatments) are becoming relevant in veterinary medicine, too. The goal of this review is to describe new therapeutic strategies for cancer treatment in veterinary medicine, including less well-known chemotherapeutic drugs.


Subject(s)
Medical Oncology/trends , Neoplasms/veterinary , Veterinary Medicine/trends , Administration, Metronomic/veterinary , Angiogenesis Inhibitors/therapeutic use , Animals , Antibodies, Monoclonal/therapeutic use , Antimetabolites, Antineoplastic/therapeutic use , Antineoplastic Agents, Alkylating/therapeutic use , Humans , Medical Oncology/methods , Molecular Targeted Therapy/veterinary , Neoplasms/drug therapy , Protein-Tyrosine Kinases/antagonists & inhibitors , Thalidomide/therapeutic use , Veterinary Medicine/methods
SELECTION OF CITATIONS
SEARCH DETAIL
...