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Eur Urol ; 13 Suppl 1: 105-7, 1987.
Article in English | MEDLINE | ID: mdl-3552693

ABSTRACT

Oral single-dose therapy with fosfomycin-trometamol (F-T) was used in 18 patients with lower urinary tract infections. The isolated bacterial strains presented a minimum inhibitory concentration of greater than 128 micrograms/ml in vitro. In spite of this 'resistance' in vitro, a clinical and bacteriological cure was obtained in 12 cases (66%). There were relapses in 2 cases, and clinical and bacteriological failure in only 2 cases. These results are due to the high urinary levels and prolonged bactericidal activity of urine after single-dose therapy with 3-5 g F-T. The clinical and biological tolerance was very good.


Subject(s)
Escherichia coli Infections/drug therapy , Fosfomycin/therapeutic use , Urinary Tract Infections/drug therapy , Administration, Oral , Adult , Aged , Drug Administration Schedule , Drug Resistance, Microbial , Female , Fosfomycin/administration & dosage , Humans , Male , Middle Aged
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