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1.
Vopr Onkol ; 59(2): 103-10, 2013.
Article in Russian | MEDLINE | ID: mdl-23814859

ABSTRACT

The article describes the clinical observation of a patient with simultaneous course of lymphoid and myeloid neoplasms. The patient developed two diseases--chronic myeloid leukemia (CML) and multiple myeloma (MM), which were confirmed by corroborated hemogram, myelogram, immunophenotyping of bone marrow cells, biopsy, immunohistochemical, cytogenetic, biochemical and radiological studies. Target therapy of CML with tyrosine kinase inhibitors (imatinib at the standard dose of 400 mg per day) has provided a complete cytogenetic remission at 6 months and major molecular response at 18 months of treatment. Administration of 2 courses of programmed treatment "BD" > (bortezomib + dexamethasone) resulted in a very good partial response, which was maintained through a year and a half. However, against the background of programmed treatment there were developed complications as polyneuropathy of grade 2, which was treated with thioctacide, milgamy, and anemia of grade 2, successfully treated with epoetin beta. Subsequently, the patient was administered continuously with imatinib 400 mg that kept the major molecular response. Relapsed MM was revealed in 20 months and confirmed by a full clinical and hematological examination. The absence of organ dysfunction allowed choosing a supervisory tactics for the patient.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biomarkers, Tumor/blood , Induction Chemotherapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnosis , Molecular Targeted Therapy/methods , Multiple Myeloma/complications , Multiple Myeloma/diagnosis , Benzamides/administration & dosage , Benzamides/adverse effects , Boronic Acids/administration & dosage , Boronic Acids/adverse effects , Bortezomib , Dexamethasone/administration & dosage , Dexamethasone/adverse effects , Female , Humans , Imatinib Mesylate , Karyotyping , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/blood , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Middle Aged , Multiple Myeloma/blood , Multiple Myeloma/drug therapy , Multiple Myeloma/pathology , Piperazines/administration & dosage , Piperazines/adverse effects , Polyneuropathies/chemically induced , Pyrazines/administration & dosage , Pyrazines/adverse effects , Pyrimidines/administration & dosage , Pyrimidines/adverse effects , Recurrence , Watchful Waiting
2.
Ter Arkh ; 76(12): 68-73, 2004.
Article in Russian | MEDLINE | ID: mdl-15724931

ABSTRACT

AIM: To characterize patients with mixed myeloid neoplasias with proliferation of neutrophils, platelets and eosinophils. MATERIAL AND METHODS: Examination and treatment results were analysed for patients with atypical myeloid leukemia (n = 4), myelodysplastic syndrome (MDS, n = 1) and thrombocytosis, MDS and eosinophilia (n = 1). The examination included morphological, histological, cytogenetic and molecular tests. RESULTS: One patient with atypical chronic myeloid leukemia was prior diagnosed to have primarily MDS with a typical aberration of chromosome 5. Two other patients had an initial morphological picture of resistant anemia with blast excess, signs of myeloproliferation and extramedullary hemopoiesis. One and two months after the first examination they received transfusions of erythrocytic mass. Just then they were found to have splenomegaly and leukocytosis due to proliferating and maturating forms of neutrophils. The course of the disease in patients with MDS, thrombocytosis and normal karyotype and in patients with MDS, eosinophilia and combined chromosomal breaks including translocation (3;12)(q21;p13) was characterized by resistance to standard programs of polychemotherapy and transformation into acute myeloblastic leukemia. CONCLUSION: In some cases atypical CML is a stage of a natural course of MDS. Some MDS variants with eosinophilia and thrombocytosis should be referred to the group of mixed myeloid neoplasias.


Subject(s)
Eosinophilia/physiopathology , Leukemia, Myelomonocytic, Chronic/physiopathology , Myelodysplastic Syndromes/physiopathology , Thrombocytosis/physiopathology , Adult , Aged , Chromosomes, Human, Pair 12 , Chromosomes, Human, Pair 3 , Eosinophilia/classification , Eosinophilia/complications , Female , Hematopoiesis, Extramedullary , Humans , Leukemia, Myelomonocytic, Chronic/classification , Leukemia, Myelomonocytic, Chronic/complications , Male , Middle Aged , Myelodysplastic Syndromes/classification , Myelodysplastic Syndromes/complications , Thrombocytosis/classification , Thrombocytosis/complications , Translocation, Genetic
4.
Vopr Onkol ; 45(3): 249-53, 1999.
Article in Russian | MEDLINE | ID: mdl-10443225

ABSTRACT

Marrow stroma was investigated in 20 patients with chronic lymphocytic leukemia (CLL). Such morphological and functional features as adipose tissue reduction, sinusoid pattern obliteration and increased number of reticular cells were identified as typical of marrow stroma in such patients. Foci of fibrosis, nuclear bodies in stromal cell nuclei and heightened proliferation of stromal precursors in organ cultures were recorded in the subendostal and perivascular areas in 60% of patients with diffuse lesions of bone marrow. Bone marrow stroma was shown to suffer morphological and functional changes which were particularly pronounced in diffuse lesions of the bone marrow. Such changes may be traced both to the malignant clone of lymphoid cells and stromal lesions.


Subject(s)
Bone Marrow/pathology , Bone Marrow/physiopathology , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukemia, Lymphocytic, Chronic, B-Cell/physiopathology , Aged , Aged, 80 and over , Humans , Middle Aged
5.
Vopr Onkol ; 44(6): 691-5, 1998.
Article in Russian | MEDLINE | ID: mdl-10087966

ABSTRACT

Data of the histological, ultrastructural and culture cell investigations of bone marrow microenvironment in 20 patients with acute lymphoblastic leukemia (ALL) are presented. Morphological and functional peculiarities of the patients' bone marrow stroma different from that in healthy subjects were identified. They included distorted histotopographic patterns of stroma-hemopoietic cell-to-cell interaction, obliteration of sinusoid counts, resorption on the sites of internal bone support structures, a changed stromal cells ratio, formation of reticular cell clusters in the subendosteal and perivascular bone marrow areas, fibroid centers, the presence of nuclear bodies in stromal cell nuclei and an intensified proliferation of stromal cell precursors in organ tissue cultures. Morphological and functional changes in bone marrow microenvironment were detected in ALL patients, which could have been caused both by malignant cell clones and stromal defects.


Subject(s)
Bone Marrow/pathology , Bone Marrow/physiopathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/physiopathology , Adult , Biopsy , Bone Marrow/ultrastructure , Humans , Middle Aged
6.
Morfologiia ; 112(6): 58-9, 1997.
Article in Russian | MEDLINE | ID: mdl-9511153

ABSTRACT

Bone marrow hematopoietic tissue and stromal elements were characterized histologically on iliac bone trepanobioptats from 8 HIV infected patients. Signs of dyserythropoiesis, dysgranulocytopoiesis, dysmegakaryocytosis, focal accumulations of plasmocytes lymphoid and histiocytic cells were demonstrated. Changes of hematopoietic tissue were accompanied by reorganization of stromal microenvironment. Growth of intramedullar reticuline cells quantity and decline in number of endosteal stromal cells were found.


Subject(s)
Bone Marrow Examination , HIV Infections/pathology , Hematopoiesis/physiology , Adult , Biopsy/methods , Female , Humans , Male , Stromal Cells/pathology
7.
Arkh Patol ; 58(1): 25-8, 1996.
Article in Russian | MEDLINE | ID: mdl-8929133

ABSTRACT

Stromal structures of the bone marrow in 22 patients with aplastic anemia (AA) were studied histophotometrically. A significant increase of the fat tissue volume and a decrease of hematopoietic tissue volume were observed. Bone tissue volume was significantly increased in 81.8% of patients, the number of endosteal cells was increased in all the patients and that of reticular cells in one third of them. The conclusion is made that hematopoietic microenvironment of the bone is not a determining factor in the majority of AA patients. Excessive bone formation might be one of the mechanisms of aplasia development.


Subject(s)
Anemia, Aplastic/pathology , Bone Marrow/pathology , Adipose Tissue/pathology , Adolescent , Adult , Anemia, Aplastic/etiology , Evaluation Studies as Topic , Female , Hematopoiesis/physiology , Humans , Male , Middle Aged , Stromal Cells/pathology
8.
Gematol Transfuziol ; 41(1): 13-6, 1996.
Article in Russian | MEDLINE | ID: mdl-8641575

ABSTRACT

The authors' investigations found plasmocytic infiltration of bone marrow and marked resorption of bone tissue in patients with multiple myeloma (MM). Instead of the expected reduction in bone marrow volume the latter slightly increased. MM patients have significantly higher quantity of endosteal stromal cells, accumulations of osteoblastic cellular elements considered as initial osteogenesis. A close correlation was revealed between bone tissue volume, number of erythroid elements in bone marrow and red cell count in peripheral blood. Volume of fatty tissues in MM patients is low. MM patients demonstrate pronounced morphofuctional disturbances in hemopoietic microenvironment of bone marrow.


Subject(s)
Bone Marrow/pathology , Hematopoiesis/physiology , Multiple Myeloma/pathology , Adult , Aged , Female , Humans , Male , Middle Aged
9.
Vopr Onkol ; 41(1): 52-5, 1995.
Article in Russian | MEDLINE | ID: mdl-7667942

ABSTRACT

The results of histological and ultrastructural studies of bone marrow hemopoietic microenvironment carried out in 27 patients with different myelodisplasias are presented. The following morphological peculiarities of bone marrow stromal tissue have been identified: abnormal localisation of immature hemopoietic cells, reticuline fibrosis, disorganized erythroid islands, and intranuclear virus-like pathologic inclusions in all stromal cells. The structure of nucleoli in endosteal and perivascular cells was changed. It was shown that morphofunctional changes in hemopoietic environment may lead to hemopoietic disorders.


Subject(s)
Bone Marrow/pathology , Myelodysplastic Syndromes/pathology , Bone Marrow/ultrastructure , Humans
10.
Gematol Transfuziol ; 39(5): 14-7, 1994.
Article in Russian | MEDLINE | ID: mdl-7896022

ABSTRACT

The paper reports storage properties of a new erythro-preservative made of the solution of modified deionized gelatin with addition of adenine and disodium phosphate. 42-day storage of red cell suspension in the above preservative was assessed in comparison to Modejele preservative according to the following characteristics: free hemoglobin, the count of osmotically unstable red cells, red cell ATP concentration, red cell deformability index, zeta-potential, extracellular potassium and sodium concentrations, amount of microclots, acid-base condition of the suspensions, blood rheology. Control and test parameters showed the greatest difference by ATP concentrations: on storage day 42 ATP in the controls made up 58.9%, in the test series 77.8% against the baseline. Red cell deformability under storage in the new preservative also tended to a decrease. The rest test parameters did not differ much in the control and test series. Acute mouse, chronic rat, rabbit and dog experiments proved low toxicity of the preservative. The repeated introduction of the preparation brought about a slight shift to hypercoagulation.


Subject(s)
Adenine , Blood Preservation/methods , Erythrocytes/drug effects , Gelatin , Phosphates , Humans , Ions , Solutions
12.
Gematol Transfuziol ; 38(7): 20-3, 1993.
Article in Russian | MEDLINE | ID: mdl-8307283

ABSTRACT

Histomorphometric findings at the study of marrow puncture specimens were compared to sonographic picture of the liver and spleen in 20 myeloid leukemia chronic. Histomorphometric and sonographic changes observed showed parallel pathological processes in the hemopoietic micro-surroundings and in the liver, spleen. Sonography proved able to considerably broaden diagnostic armory of the physician, to prognosticate leukemia outcomes, thus suggesting a differential approach to the disease treatment.


Subject(s)
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/diagnostic imaging , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Adolescent , Adult , Female , Humans , Male , Middle Aged , Ultrasonography
13.
Gematol Transfuziol ; 38(6): 44-5, 1993 Jun.
Article in Russian | MEDLINE | ID: mdl-8307277

ABSTRACT

Histologic specimens of the bone marrow were obtained from healthy subjects and aplastic anemia (AA) ones. Comparison of the histomorphometry was indicative of an increase in spongy bone tissue and in the number of osteoid cells in AA. This indirectly suggested enhanced proliferative activity of osteogenic precursors and osteosynthesis in AA. Interrelationship is probable between osteogenesis and hemopoiesis.


Subject(s)
Anemia, Aplastic/physiopathology , Osteogenesis/physiology , Adult , Humans
14.
Gematol Transfuziol ; 38(3): 11-3, 1993 Mar.
Article in Russian | MEDLINE | ID: mdl-8020725

ABSTRACT

Marrow trepan biopsy was performed in 11 patients upon diagnosis of chronic myeloid leukemia and in clinicohematological remission of the disease. The patients were treated with alpha 2-interferon (reaferon) versus conventional myelosan (6 and 5 patients, respectively). The biopsies were studied histomorphometrically. In reaferon group the number of megakaryocytes and endosteal stromal cells diminished. This may be due to an indirect action of reaferon on hemopoietic tissue via endosteal cells of the marrow stroma. Reaferon is recommended for myeloid leukemia chronic with a granulocytic-megakaryocytic histological variant of the disease.


Subject(s)
Bone Marrow/drug effects , Interferon Type I/therapeutic use , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy , Adolescent , Adult , Biopsy, Needle , Bone Marrow/physiopathology , Bone Marrow Examination , Busulfan/therapeutic use , Drug Evaluation , Female , Humans , Interferon alpha-2 , Interferon-alpha , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/physiopathology , Male , Middle Aged , Recombinant Proteins
15.
Gematol Transfuziol ; 38(1): 11-5, 1993 Jan.
Article in Russian | MEDLINE | ID: mdl-8020695

ABSTRACT

Unlike hemopoietic cell, stromal cells of aplastic anemia patients' bone marrow undergo pathological shifts. This has been proved by ultrastructural investigations which showed intranuclear inclusions structurally similar to virus bodies. The latter are divided into three types this allowing follow-up of the inclusions to mature forms seen in the stromal cells cytoplasm. The findings suggest primary viral affection of stromal cellular elements of aplastic anemia patients' bone marrow. The attention is also drawn to ultrastructural shifts recorded in adipose cells in aplastic anemia.


Subject(s)
Anemia, Aplastic/pathology , Bone Marrow/ultrastructure , Adipocytes/ultrastructure , Anemia, Aplastic/etiology , Biopsy , Cytoplasm/ultrastructure , Humans , Inclusion Bodies, Viral/ultrastructure , Microscopy, Electron
16.
Gematol Transfuziol ; 36(3): 11-5, 1991 Mar.
Article in Russian | MEDLINE | ID: mdl-2065950

ABSTRACT

The results have been presented of electron-microscopic and ultracytochemical investigations of sinusoidal vessels, fat, reticular and endosteal cells of the bone marrow from the iliac bone fragments of 30 normal subjects. Close morphological and functional relationships have been established between the structures of the hemopoietic microenvironment and hemopoietic cells, and the role of certain stromal elements in the maintenance of the hemopoietic function has been specified.


Subject(s)
Bone Marrow Cells , Hematopoietic Stem Cells/ultrastructure , Ilium/cytology , Hematopoiesis/physiology , Hematopoietic Stem Cells/physiology , Humans , Microscopy, Electron
17.
Klin Med (Mosk) ; 69(1): 94-7, 1991 Jan.
Article in Russian | MEDLINE | ID: mdl-2023411

ABSTRACT

Marrow histomorphometry was performed in 73 untreated chronic lymphoid leukemia (CLL) sufferers. Follow-up results are available for 36 of them: 25 treated and 11 untreated with chemotherapy. The method of marrow histomorphometry allows recognition of three CLL forms: diffuse, diffuse-focal and focal; helps to determine indications to chemotherapy, assess its efficacy, prognosticate the disease course; is more reliable than clinical and laboratory findings.


Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow/drug effects , Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy , Lymph Nodes/drug effects , Lymphocytes/drug effects , Adult , Aged , Bone Marrow/pathology , Cyclophosphamide/administration & dosage , Humans , Leukemia, Lymphocytic, Chronic, B-Cell/blood , Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukocyte Count/drug effects , Lymph Nodes/pathology , Lymphocytes/pathology , Middle Aged , Prednisone/administration & dosage , Prognosis , Vincristine/administration & dosage
18.
Klin Khir (1962) ; (4): 10-2, 1991.
Article in Russian | MEDLINE | ID: mdl-1881065

ABSTRACT

In patients with purulent peritonitis, the severe immunodepression and suppression of proliferative activity of stem elements of hemopoietic tissue stroma were revealed. The effectiveness of the use as an immunomodulator of the preparation "Antilympholin" which has the marked immunostimulating properties is shown.


Subject(s)
Antilymphocyte Serum/therapeutic use , Hematopoiesis/physiology , Immunization, Passive , Lymphopenia/therapy , Peritonitis/immunology , T-Lymphocytes/immunology , Adjuvants, Immunologic , Adolescent , Adult , Aged , Humans , Lymphopenia/etiology , Middle Aged , Peritonitis/blood , Peritonitis/therapy , T-Lymphocytes/pathology
19.
Gematol Transfuziol ; 35(1): 27-31, 1990 Jan.
Article in Russian | MEDLINE | ID: mdl-2328901

ABSTRACT

Cultural, ultrastructural, cytochemical and histological investigations of bone marrow tissue were conducted in 26 patients with varying types of preleukemia states. A number of early structural, morphological and functional signs of hemopoietic disorders of different character and manifestation degree have been revealed. Particularly, a relationship has been established between the pathologic changes appearing in the bone marrow stroma and disorders in the morphological and functional state of the hemopoietic cells.


Subject(s)
Anemia, Refractory/pathology , Bone Marrow/pathology , Hematopoiesis/physiology , Hematopoietic Stem Cells/ultrastructure , Preleukemia/pathology , Anemia, Refractory/blood , Blood Cell Count , Cell Differentiation/physiology , Hematopoietic Stem Cells/pathology , Hematopoietic Stem Cells/physiology , Humans , In Vitro Techniques , Microscopy, Electron , Preleukemia/blood
20.
Biull Eksp Biol Med ; 107(4): 488-90, 1989 Apr.
Article in Russian | MEDLINE | ID: mdl-2720169

ABSTRACT

The study of chronic toxicity of polymerized hemoglobin solutions (PHb) has demonstrated the relationship between the dose of the solution administered and the level of functional and morphological changes induced in various organs of experimental animals. Lower doses (1.8 g/kg) of PHb had no effect on the values of protein and carbohydrate metabolism, while the high doses (10-15 g/kg) of PHb resulted in the impairment of protein synthesis, morphological changes in the spleen and lymphatic nodes.


Subject(s)
Blood Substitutes/toxicity , Blood/drug effects , Hemoglobins/toxicity , Liver/drug effects , Pyridoxal Phosphate/analogs & derivatives , Spleen/drug effects , Animals , Dogs , Dose-Response Relationship, Drug , Male , Organ Size/drug effects , Prohibitins , Pyridoxal Phosphate/toxicity , Rabbits , Rats
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