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Acta Crystallogr F Struct Biol Commun
; 79(Pt 12): 295-300, 2023 Dec 01.
Article
in English
| MEDLINE
| ID: mdl-38051309
ABSTRACT
Replication initiator proteins (Reps) from the HUH endonuclease family process specific single-stranded DNA sequences to initiate rolling-circle replication in viruses. Here, the first crystal structure of the apo state of a Rep domain from the smacovirus family is reported. The structure of the human smacovirus 1 Rep domain was obtained at 1.33â Å resolution and represents an expansion of the HUH endonuclease superfamily, allowing greater diversity in bioconjugation-tag applications.