[Concentration of light hydrocarbons in exhaled air depending on the risk factors of metabolic disorder].

In this study we investigated the effect of risk factors of metabolic syndrome on the content of light hydrocarbons (C2-C3) in exhaled air. We used a gas chromatograph with a short multi-channel column. As a result, sex differences in concentrations of light hydrocarbons presented in exhaled air were found. In addition, such factors as smoking and diabetes mellitus type 2 in relatives reflect on the exhaled C2-C3 compounds only in women. But the overweight correlates with the exhaled acetone (C3) only in men. Thus, the fact that the metabolic changes caused by the presence of risk factors of metabolic syndrome lead to changes in gas composition of exhaled air and can be registered and used for early diagnosis has been ascertained.

[Insulin-glucose parameters in healthy women and patients with arterial hypertension and ischemic heart disease in dependence on age and follicle-stimulating hormone levels].

Insulin-glucose parameters in healthy women do not significantly change with changes of functional state of ovaries. Women with hypertension and normal levels of glycemia have significantly higher values of basal insulinemia and HOMA-R index reflecting presence of moderate insulin resistance degree of which is more pronounced in middle aged patients. In women with documented ischemic heart disease values of basal insulinemia, HOMA-R index, and glycemia are comparable with those in patients with hypertension and follicle-stimulating hormone level above 30 IE/l and significantly differ from corresponding parameters in healthy women in peri- and postmenopause.

[Current views about the role of purin metabolism disorders in patients with arterial hypertension and losartan potentialities].

The analysis of correlation between cardiovascular diseases and hyperuricaemia as a component of methabolic syndrome has been performed; the emphasis has been done on predominant mechanism of its development -- reduction of renal clearance. The need for primary prophylaxis of stroke with a help of safe metabolically antihypertensive therapy has been substantiated. The results of secondary analysis of LIFE study represented its results on effective primary prophylaxis of stroke depending on the dynamic of serum uric acid levels taking into account uricosuric effect of losartan have been discussed.

[Hormone-producing function of the ovaries in young and middle-aged women with arterial hypertension and coronary heart disease].

The study demonstrates that arterial hypertension itself, judging by main anthropometric variables such as body weight index and waist to hip ratio, together with the estrogen-producing function of the ovaries, evaluated by measuring follicle-stimulating hormone levels, contributes substantially to the forming of abdominal obesity in normo- and hypertensive women. All the above confirms close correlation between hemodynamic and metabolic disturbances which eventually result in coronary heart disease in young and middle-aged women.

[On the possible prooxidant role of insulinemia in formation of metabolic syndrome in men and women.]. / O vozmozhnoi prooksidantnoi roli insulinemii v formirovanii metabolicheskogo sindroma u muzhchin i zhenshchin.

Levels of basal insulinemia, malondialdehyde (an index of oxidative stress) and some metabolic parameters were studied in 143 men and 83 women aged 48.3+/-0.7 years with incomplete metabolic syndrome: hypertension, abdominal obesity, dyslipoproteinemia with normoglycemia. Basal insulinemia correlated significantly with malondialdehyde levels both in men and women. Slose relationship was also found between basal insulinemia and waist circumference.

[Predictive value of insulin-glucose homeostasis markers in patients with metabolic syndrome X]. / Analiz informativnosti pokazatelei insulingliukoznogo gomeostaza u bol'nykh s metabolicheskim sindromom X.

AIM: To clarify informative value of secretory ability of pancreatic beta-cells and correspondence of insulin values to glycemia in the course of standard glucose tolerance test (GTT) in detection of insulin-resistance in patients with arterial hypertension (AH) to verify metabolic syndrome (MS). MATERIAL AND METHODS: Correlation and factor analyses were performed of correlations between glycemia, immunoreactive insulin (IRI), C-peptide, glucose/IRI in the course of GTT in 111 AH patients divided into groups by the sum of metabolic disturbances. RESULTS: The greatest number of correlations were seen for glucose/IRI fasting index. According to the factor analysis, changed sensitivity to insulin and hyperinsulinemia are the first stage of metabolic disturbances in AH irrespective of body mass. In obesity the number of the above correlations is maximal. Multivariance analysis has shown significant differences between AH patients and healthy subjects irrespective of body mass and glucose tolerance. CONCLUSION: Basal index glucose/IRI < 6 relative units is informative in all the studied variants of metabolic syndrome as regards insulin resistance.

[Variants of hyperosmolarity syndrome in diabetes mellitus patients in critical conditions]. / Varianty giperosmoliarnogo sindroma u bol'nykh sakharnym diabetom v urgentnoi terapevticheskoi klinike]

Recently, high lethality of critical conditions in diabetes mellitus patients has been attributed to the presence of hyperosmolarity syndrome. The authors consider this problem in terms of plasm osmolarity parameters, pathogenesis and diagnostic criteria of hyperosmolarity. Present-day clinical variants of hyperosmolarity syndrome are characterized.