Subject(s)
COVID-19/complications , Mouth Diseases/epidemiology , SARS-CoV-2/isolation & purification , Skin Diseases/epidemiology , COVID-19/diagnosis , COVID-19/immunology , COVID-19/virology , COVID-19 Nucleic Acid Testing/statistics & numerical data , Female , Foot , Hand , Humans , Male , Middle Aged , Mobile Health Units/statistics & numerical data , Mouth Diseases/etiology , Mouth Diseases/pathology , Mouth Mucosa/immunology , Mouth Mucosa/pathology , Prevalence , RNA, Viral/isolation & purification , SARS-CoV-2/immunology , Severity of Illness Index , Skin/immunology , Skin/pathology , Skin Diseases/etiology , Skin Diseases/pathology , Spain/epidemiologySubject(s)
Coronavirus Infections/complications , Pneumonia, Viral/complications , Prednisone/administration & dosage , Severe Acute Respiratory Syndrome/etiology , Vasculitis, Leukocytoclastic, Cutaneous/pathology , Aged, 80 and over , Biopsy, Needle , COVID-19 , Coronavirus Infections/diagnosis , Female , Follow-Up Studies , Humans , Immunohistochemistry , Pandemics , Pneumonia, Viral/diagnosis , Risk Assessment , Severe Acute Respiratory Syndrome/drug therapy , Severe Acute Respiratory Syndrome/pathology , Treatment Outcome , Vasculitis, Leukocytoclastic, Cutaneous/drug therapy , Vasculitis, Leukocytoclastic, Cutaneous/etiologyABSTRACT
BACKGROUND: Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. MATERIAL AND METHODS: 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed. RESULTS: The presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls. CONCLUSION: In this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCs.
Subject(s)
Bisphosphonate-Associated Osteonecrosis of the Jaw , Bone Density Conservation Agents , Osteonecrosis , Animals , Diphosphonates , Disease Models, Animal , Imidazoles , Mice , Rats , Rats, Wistar , Stem Cells , Tooth ExtractionABSTRACT
Chagas disease is a parasitosis endemic to South America. It is normally treated with benznidazole as first choice, which has been associated with numerous cutaneous reactions. However, very few benznidazole-associated severe cutaneous adverse reactions have been reported to date. The rise of Chagas disease in nonendemic countries represents a growing public health challenge. We report two patients who met the criteria for drug reaction with eosinophilia and systemic symptoms syndrome and Stevens-Johnson syndrome/toxic epidermal necrolysis according to the RegiSCAR scoring systems. They were thus deemed overlapping cases, with a lymphocyte transformation test positive for benznidazole. Both required intensive care unit admission and both survived. Considering the rising application of this drug for trypanosomiasis in immigrant populations, clinicians should be aware of this newly reported, potentially life-threatening risk.
Subject(s)
Chagas Disease/drug therapy , Drug Eruptions/etiology , Nitroimidazoles/adverse effects , Stevens-Johnson Syndrome/etiology , Trypanocidal Agents/adverse effects , Adult , Dermatitis, Exfoliative/chemically induced , Edema/chemically induced , Female , Humans , Male , Stevens-Johnson Syndrome/diagnosisSubject(s)
Humans , Female , Middle Aged , Arteritis/complications , Arteritis/diagnosis , Polyarteritis Nodosa/complications , Polyarteritis Nodosa/physiopathology , Vasculitis/complications , Vasculitis/diagnosis , Vasculitis/therapy , Arteritis/physiopathology , Arteritis/therapy , Macular Degeneration/complications , Vasculitis/physiopathology , Diagnosis, DifferentialSubject(s)
Actinobacillus Infections/diagnosis , Aggregatibacter actinomycetemcomitans/isolation & purification , Endocarditis, Subacute Bacterial/diagnosis , Fingers/pathology , Hand Dermatoses/etiology , Actinobacillus Infections/complications , Actinobacillus Infections/diagnostic imaging , Actinobacillus Infections/drug therapy , Actinobacillus Infections/microbiology , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/therapeutic use , Aortic Valve/diagnostic imaging , Aortic Valve/microbiology , Ceftriaxone/administration & dosage , Ceftriaxone/therapeutic use , Ciprofloxacin/administration & dosage , Ciprofloxacin/therapeutic use , Drug Therapy, Combination , Edema/etiology , Endocarditis, Subacute Bacterial/complications , Endocarditis, Subacute Bacterial/diagnostic imaging , Endocarditis, Subacute Bacterial/drug therapy , Endocarditis, Subacute Bacterial/microbiology , Gentamicins/administration & dosage , Gentamicins/therapeutic use , Hand Dermatoses/pathology , Heart Valve Prosthesis , Hemorrhage/etiology , Humans , Male , Middle Aged , Nail Diseases/etiology , Rheumatic Heart Disease/complications , UltrasonographyABSTRACT
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