ABSTRACT
The coexistence of two or more tumours in the same patient is unusual, but even rarer is the metastasis of one tumour to another. Most reports are based on evidence from autopsies; very few refer to surgical specimens. The most common primary tumour is pulmonary carcinoma and most frequent metastatic tumour is renal clear cell carcinoma. We present the case of a 54 year-old female with a past history of infiltrating ductal carcinoma of the breast with metastases in lung, lymph nodes and bone. Three months previously to her referral to us, she had developed a renal mass and underwent nephrectomy. Histopathology revealed a renal chromophobe cell carcinoma with intratumoral breast cancer metastasis. We describe the histopathological, immunohistochemical and molecular features and review the recent literature.
Subject(s)
Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/secondary , Carcinoma, Renal Cell/pathology , Kidney Neoplasms/secondary , Neoplasms, Multiple Primary/pathology , Biomarkers, Tumor/analysis , Breast Neoplasms/therapy , Carcinoma, Ductal, Breast/chemistry , Carcinoma, Renal Cell/surgery , Combined Modality Therapy , Diagnosis, Differential , Female , Humans , Kidney Neoplasms/chemistry , Kidney Neoplasms/pathology , Kidney Neoplasms/surgery , Middle Aged , Neoplasm Proteins/analysis , Nephrectomy , Prognosis , Receptor, ErbB-2/analysisABSTRACT
Pseudomyogenic hemangioendothelioma, also called epithelioid sarcoma-like hemangioendothelioma, is a rare, vascular neoplasm usually with indolent behaviour. It was introduced in the latest World Health Organization (WHO) Classification of Tumours of Soft Tissue. We report a case of a 45 year-old patient presenting with a localized, palpable and slightly painful lesion in the left arm. Histologically it consisted of fascicles of spindle and epithelioid cells with ample eosinophilic cytoplasm, without nuclear pleomorphism or significant mitotic activity. Tumour cells showed diffuse expression for cytokeratin AE1/AE3, CD31 and FLI1, intact expression for INI1 and negativity for CD34. We describe the clinical, histological, molecular and immunohistochemical features of pseudomyogenic hemangioendothelioma and review the pertinent literature.
Subject(s)
Hemangioendothelioma/pathology , Muscle Neoplasms/pathology , Biomarkers, Tumor/analysis , Cytoplasm/pathology , Elbow , Female , Hemangioendothelioma/chemistry , Hemangioendothelioma/diagnosis , Humans , Middle Aged , Muscle Neoplasms/chemistry , Muscle Neoplasms/diagnosis , Neoplasm Proteins/analysis , Neutrophil InfiltrationABSTRACT
El hemangioendotelioma pseudomiogénico, también conocido como hemangioendotelioma tipo sarcoma epitelioide, es una neoplasia vascular infrecuente de comportamiento habitualmente indolente introducida en la última clasificación de tumores de partes blandas de la clasificación de la Organización Mundial de la Salud (OMS). Presentamos el caso de una paciente de 45años con una lesión localizada en el miembro superior izquierdo. Clínicamente se presentó como una lesión palpable y discretamente dolorosa. Histológicamente estaba constituida por fascículos de células fusiformes y células de aspecto epitelioide con amplio citoplasma eosinófilo sin pleomorfismo nuclear ni actividad mitótica significativa. Las células tumorales mostraron expresión fuerte y difusa para citoqueratina AE1/AE3, CD31 y FLI1, manteniendo la expresión nuclear de INI1 y existiendo negatividad para CD34. En el presente artículo revisamos la literatura médica sobre esta entidad y describimos sus características clínicas, histológicas, inmunohistoquímicas y moleculares (AU)
Pseudomyogenic hemangioendothelioma, also called epithelioid sarcoma-like hemangioendothelioma, is a rare, vascular neoplasm usually with indolent behaviour. It was introduced in the latest World Health Organization (WHO) Classification of Tumours of Soft Tissue. We report a case of a 45 year-old patient presenting with a localized, palpable and slightly painful lesion in the left arm. Histologically it consisted of fascicles of spindle and epithelioid cells with ample eosinophilic cytoplasm, without nuclear pleomorphism or significant mitotic activity. Tumour cells showed diffuse expression for cytokeratin AE1/AE3, CD31 and FLI1, intact expression for INI1 and negativity for CD34. We describe the clinical, histological, molecular and immunohistochemical features of pseudomyogenic hemangioendothelioma and review the pertinent literature (AU)
Subject(s)
Humans , Female , Adult , Hemangioendothelioma/diagnosis , Hemangioendothelioma/pathology , Immunohistochemistry/methods , Immunohistochemistry/standards , Cytoplasm/pathology , Diagnosis, Differential , Upper Extremity/pathology , Sarcoma/pathology , Immunohistochemistry , Pathology/methods , Pathology/trendsABSTRACT
La coexistencia de 2 o más tumores en un paciente es un hecho poco frecuente y más infrecuentes son las metástasis de tumor a tumor. La mayoría de las publicaciones incluyen hallazgos autópsicos y, en menor número, hallazgos en piezas quirúrgicas-biopsias. El origen primario más frecuente es el carcinoma de pulmón, siendo el receptor más frecuente el carcinoma de células claras renal. Describimos el caso de una paciente de 54años con historia remota de carcinoma ductal infiltrante de mama derecha, que presentó en el transcurso afectación metastásica a nivel pulmonar, ganglionar, óseo y hace 3 meses una lesión en riñón derecho. Se sometió a nefrectomía. El estudio anatomopatológico reveló un carcinoma renal de células cromófobas con metástasis intratumoral de carcinoma ductal infiltrante de mama. Se describen los hallazgos histológicos, inmunohistoquímicos y moleculares, con revisión de la literatura reciente (AU)
The coexistence of two or more tumours in the same patient is unusual, but even rarer is the metastasis of one tumour to another. Most reports are based on evidence from autopsies; very few refer to surgical specimens. The most common primary tumour is pulmonary carcinoma and most frequent metastatic tumour is renal clear cell carcinoma. We present the case of a 54 year-old female with a past history of infiltrating ductal carcinoma of the breast with metastases in lung, lymph nodes and bone. Three months previously to her referral to us, she had developed a renal mass and underwent nephrectomy. Histopathology revealed a renal chromophobe cell carcinoma with intratumoral breast cancer metastasis. We describe the histopathological, immunohistochemical and molecular features and review the recent literature (AU)
Subject(s)
Humans , Female , Middle Aged , Carcinoma, Ductal, Breast/complications , Carcinoma, Ductal, Breast/diagnosis , Carcinoma, Ductal, Breast/pathology , Neoplasm Metastasis/pathology , Carcinoma, Renal Cell/diagnosis , Carcinoma, Renal Cell/pathology , Diagnosis, Differential , Nephrectomy/methods , Immunohistochemistry/methods , Immunohistochemistry , Photomicrography/methods , Carcinoma, Renal Cell , Kidney/pathology , KidneyABSTRACT
El tumor híbrido de vaina de nervio periférico es una neoplasia mesenquimal benigna de la que se han publicado pocos casos, que ha sido incluida recientemente en la clasificación de la OMS de partes blandas, y que muestra una amplia distribución, afectando predominantemente a extremidades y tronco. Los hallazgos histológicos revelan la presencia de 2 o más componentes celulares diferentes originados en la vaina del nervio periférico con una proporción variable de neurofibroma, schwannoma y perineuroma. Describimos el caso de un paciente varón de 65 años de edad con un nódulo no doloroso en el quinto dedo de mano izquierda, que presenta componentes de neurofibroma y perineuroma. Describimos los hallazgos histológicos e inmunohistoquímicos reportados en la literatura más reciente acerca de este tumor peculiar y poco reconocido (AU)
Hybrid peripheral nerve sheath tumour is a rare mesenchymal benign neoplasm recently included in the WHO classification of soft tissue tumours. It has a wide distribution but predominantly affects limbs and trunk. Histological findings reveal the presence of 2 or more cellular components originating in the peripheral nerve sheath with variable proportions of neurofibroma, schwannoma and perineurioma. We report a case of a 65-year-old male with a painless nodule in the 5th finger of his left hand which showed microscopic features of neurofibroma and perineurioma. We review the histological and immunohistochemical findings of this unusual, and often over-looked, tumour in the recent literature (AU)
