Subject(s)
Antifungal Agents/therapeutic use , Dermatomycoses/drug therapy , Foot Dermatoses/drug therapy , Antifungal Agents/adverse effects , Antifungal Agents/pharmacokinetics , Dermatomycoses/metabolism , Endocrine Glands/drug effects , Foot Dermatoses/metabolism , Humans , Liver/drug effects , Tissue DistributionABSTRACT
The authors review the data on the incidence and type of fungal involvement of the face in T. rubrum-induced trichophytosis in the USSR and other countries of the world. Exquisite localizations are cited, i.e. involvement of the lacrimal nasal channel, external acoustic meatus, eyelids and eyelashes. Extraordinary variants of trichophytosis of the face are described: tumor-like, wart-like, infiltrative suppurative, seborrheal, as well as the forms simulating photodermatoses, perioral dermatitis, etc. 35 case histories of patients suffering from this condition, observed by the authors over 21 years, are cited, and photographs are presented of 8 of them with the most incident trichophytosis variants, i.e. seborrheal, infiltrative suppurative, and those simulating discoid lupus erythematosus and perioral dermatitis. The authors emphasize that fungal nature should be excluded in cases with uncommon course of this or that dermatosis.
Subject(s)
Facial Dermatoses/diagnosis , Tinea/diagnosis , Adult , Dermatitis, Seborrheic/diagnosis , Diagnosis, Differential , Face , Facial Dermatoses/epidemiology , Facial Dermatoses/pathology , Female , Humans , Male , Prevalence , Tinea/epidemiology , Tinea/pathologyABSTRACT
A total of 201 patients suffering from trichophytosis induced by T. rubrum have been effectively treated with nizoral combined with external management: removal of the nail plates, keratolytic and fungicidal therapy. Treatment with this drug should be preceded by a comprehensive clinical and laboratory examination.
Subject(s)
Ketoconazole/therapeutic use , Onychomycosis/drug therapy , Adolescent , Adult , Aged , Chronic Disease , Drug Evaluation , Female , Foot Dermatoses/drug therapy , Hand Dermatoses/drug therapy , Humans , Ketoconazole/adverse effects , Male , Middle AgedABSTRACT
Three cases of chromomycosis, a disease rare in this country, are described. The authors analyze the difficulties associated with the diagnosis of this disease and review the methods of its treatment. All the patients reported in this paper have been administered polychemotherapy including intrafocal injections of amphotericin B (an antimycotic drug), iodine preparations, vitamin D2, and nizoral. This therapy has been effective in all the cases. The employed mode of administration of amphotericin B (injections round the infection focus) helps create a high concentration of the drug in the involved skin sites, resolve the nearby foci, and rules out the general reactions. Combined therapy cuts down the length of treatment.
