[The efficacy of antihypertension drugs and their combinations in the non-treated hypertension].

In case of non-treated hypertension several medications and their combinations were studied (captopril, and moxonidine as such, captopril + nifedipine, captopril + moxonidine). Moxonidine to be more effective in patients with the prevalence of the sympathetic tone, captopril in patients without increased sympathetic activity. At a combination of captopril + nifedipine efficiency of therapy was reduced, and at a combination moxonidine + nifedipine - increased. Beyond that administration of captopril + nifedipine possessed more side effects, as to compare with the moxonidine + nifedipine.

[Acute management at the rising of arterial pressure which is not menacing to a life].

491 hypertensive (non life threatening) patients were examined for hemodynamic changers and variance of the sinus rhythm after administration of clonidine, nifedipine, captopril, and mocsonidine. BP was done by the caff method, hemodynamic by the integral rheography, variance of the sinus rhythm - according to the recommendations of the International ECG Society. It was showed nifedipine and captopril were most effective among the others in case of moderate hypertension without sympathetic hyperfunction. In patients with severe and moderate hypertension follow up with the hyperfunction of the sympathetic nervous system clonidine and mocsonidine showed the major efficacy. In comparison to clonidine, mocsidimin is the medication which is not on the list, and beyond that it provided less adverse effects.

Acute bradyarrhythmia induced by occlusion of the posterior interventricular branch of the right coronary artery.

Ligation of the posterior interventricular branch of the right coronary artery in rats induced bradyarrhythmia similar by its pathophysiological mechanisms to bradyarrhythmias developed in humans during acute ischemia of the posterior cardiac wall. The type and severity of arrhythmia and conduction disturbances, their latency and duration, and correlation with the volume of damaged myocardial tissue were determined. The efficacy and safety of the use of methylxanthines during acute myocardial ischemia was proved.

[The effective assessment of the severity of the course of a myocardial infarct by the sinus rhythm status]. / Operativnaia otsenka tiazhesti techeniia infarkta miokarda po sostoianiiu sinusovogo ritma.

Heart rhythm was studied in 35 patients with primary and in 33 patients with recurrent through-and-through myocardial infarction, in 46 patients with other forms of coronary heart disease and in 48 healthy subjects. Variation range and amplitude of mode were established to be the most significant characteristics of sinus rhythm which alongside with data on premorbid state and functional reserves of the heart can be used in the early hours after the onset for assessment of myocardial infarction severity. Sinus rhythm monitoring allows to suspect timely haemodynamic changes and detect precursors of myocardial fibrillation. Changes of sinus rhythm in response to administration of drugs make it possible to specify functional state of the heart and estimate quality of treatment.

[The use of clofelin in the acute period of myocardial infarct]. / O primenenii klofelina v ostrom periode infarkta miokarda.

Data are reported on the action of intravenous clophelin in 30 patients administered within the first 24 hours of myocardial infarction. The agent exhibited a significant analgetic effect, sedative action and normalized the main hemodynamic values. The effect of clophelin on the hemodynamics depended on its initial state. The possibility is shown to predict the pain-killing and hemodynamic effects of the drug by the initial response.