1.
Arch Pharm (Weinheim)
; 337(8): 434-9, 2004 Aug.
Article
in English
| MEDLINE
| ID: mdl-15293262
ABSTRACT
The new and efficient synthesis of the title heterocyclic ring system is described starting from suitable 2-chloro-1, 8-naphthyridines. The synthesized 6H-indolo[2, 3-b][1, 8]naphthyridine derivatives were tested in vitro on 55 tumor cell lines for their anticancer properties. The presence of the acetylamino moiety at position 3 in the main ring system proved to be crucial for the cytostatic activity of this class of compounds.