A joint coordinate system proposal for the study of the trapeziometacarpal joint kinematics.

The International Society of Biomechanics (ISB) has recommended a standardisation for the motion reporting of almost all human joints. This study proposes an adaptation for the trapeziometacarpal joint. The definition of the segment coordinate system of both trapezium and first metacarpal is based on functional anatomy. The definition of the joint coordinate system (JCS) is guided by the two degrees of freedom of the joint, i.e. flexion-extension about a trapezium axis and abduction-adduction about a first metacarpal axis. The rotations obtained using three methods are compared on the same data: the fixed axes sequence proposed by Cooney et al., the mobile axes sequence proposed by the ISB and our alternative mobile axes sequence. The rotation amplitudes show a difference of 9 degrees in flexion-extension, 2 degrees in abduction-adduction and 13 degrees in internal-external rotation. This study emphasizes the importance of adapting the JCS to the functional anatomy of each particular joint.

[How to define the joint movements unambiguously: proposal of standardization for the trapezometacarpal joint]. / Comment définir sans ambiguïté les mouvements d'une articulation: proposition de standardisation pour l'articulation trapézométacarpienne.

In order to define the movements of a joint, clinicians usually use anatomic terms. These terms are clearly understandable for a simple movement, defined in an anatomic plane. However, these terms are ambiguous for complex movements or for movements out of an anatomic plane. This, for instance, is the case for the internal-external axial rotation of the trapezometacarpal joint. For the study of complex movements, engineers preferentially use methods such as Euler angles, which correspond to three angles about three axes chosen in a defined order or sequence. Thus, the International Society of Biomechanics has proposed a joint coordinate system definition where every axis is associated with a functional degree of freedom of the joint. The first and third axes are embedded in the proximal and distal segments whilst the second axis, called the "floating" axis, is always orthogonal to the other two. The present work deals with the application of this concept to the trapezometacarpal joint. The two principal degrees of freedom, of flexion-extension and of abduction-adduction are defined following classical anatomical axes of respectively the trapezium and first metacarpal. Conversely, internal-external axial rotation is defined about the "floating" axis which does not have anatomical definition but can be geometrically deduced from the two others.

Intrinsic mechanical properties of trabecular calcaneus determined by finite-element models using 3D synchrotron microtomography.

To determine intrinsic mechanical properties (elastic and failure) of trabecular calcaneus bone, chosen as a good predictor of hip fracture, we looked for the influence of image's size on a numerical simulation. One cubic sample of cancellous bone (9 x 9 x 9 mm(3)) was removed from the body of the calcaneus (6 females, 6 males, 79+/-9 yr). These samples were tested under compressive loading. Before compressive testing, these samples were imaged at 10.13 microm resolution using a 3D microcomputed tomography (muCT) (ESRF, France). The muCT images were converted to finite-element models. Depending on the bone density values (BV/TV), we compared two different finite element models: a linear hexahedral and a linear beam finite element models. Apparent experimental Young's modulus (E(app)(exp)) and maximum apparent experimental compressive stress (sigma(max)(exp)) were significantly correlated with bone density obtained by Archimedes's test (E(app)(exp)=236+/-231 MPa [19-742 MPa], sigma(max)(exp)=2.61+/-1.97 MPa [0.28-5.81 MPa], r>0.80, p<0.001). Under threshold at 40 microm, the size of the numerical samples (5.18(3) and 6.68(3)mm(3)) seems to be an important parameter on the accuracy of the results. The numerical trabecular Young's modulus was widely higher (E(trabecular)(num)=34,182+/-22,830 MPa [9700-87,211 MPa]) for the larger numerical samples and high BV/TV than those found classically by other techniques (4700-15,000 MPa). For rod-like bone samples (BV/TV<12%, n=7), Young's modulus, using linear beam element (E(trabecular)(num-skeleton): 10,305+/-5500 MPa), were closer to the Young's modulus found by other techniques. Those results show the limitation of hexahedral finite elements at 40 microm, mostly used, for thin trabecular structures.

[The trapezio-metacarpal joint: the strain of the ligaments as a function of the thumb position. Study on an enlarged model]. / L'articulation trapézométacarpienne: l'allongement des ligaments en fonction de la position du pouce. Etude sur modèle agrandi.

INTRODUCTION: The aim of this paper was to develop an enlarged anatomical model of the trapezio-metacarpal joint in order to measure the strains on the ligaments when this joint was passively moved in several directions under constant loading. MATERIAL AND METHOD: A model of the two first rays of the hand was made in polystyrene, at a X3 enlargement, and the ligaments substituted by rubber bands with well characterized mechanical properties so as to reproduce the actual ratio of stiffness (approximately = 10) of the different tissues (bones and ligaments) found in real life. The first metacarpal was moved in 6 directions as described by Ebskov (1970) and Pieron (1973, 1980) using a small spring exerting a constant force (1.5 N) tilted at 30 degrees with respect to the transverse plane. The strain was measured between two white marks for each model ligament and each direction respectively, and the percentage of lengthening was calculated. A statistical study was performed using the non-parametrical Test of Wilcoxon in order to compare the ligament strains obtained in the different directions of loading. RESULTS: The largest strains were observed in the intermetacarpal ligament and in the anterior oblique ligament reaching 26 to 39% in direction J (posteromedial) and in direction L (posterolateral). Deformations of the two parts of the dorsoradial ligament and of the posterior oblique ligament were equal or inferior to 12% and were observed in the other 4 directions: D, F, K, I (Anterolateral, maximal anteposition, anteromedial, medial) and their combinations. CONCLUSION: . These data may be useful for helping the understanding of the biomechanics of the basal joint of the thumb. Nevertheless, we are dealing here with a simplified model, which must be considered with caution if the results are to be applied to the living joint.

Relationship between compressive properties of human os calcis cancellous bone and microarchitecture assessed from 2D and 3D synchrotron microtomography.

The aim of this study was to determine the contribution of 2D and 3D microarchitectural characteristics in the assessment of the mechanical strength of os calcis cancellous bone. A sample of cancellous bone was removed in a medio-lateral direction from the posterior body of calcaneus, taken at autopsy in 17 subjects aged 61-91 years. The sample was first used for the assessment of morphological parameters from 2D morphometry and 3D synchrotron microtomography (microCT) (spatial resolution=10 microm). The 2D morphometry was obtained from three slices extracted from the 3D microCT images. Very good concordance was shown between 3D microCT slices and the corresponding physical histologic slices. In 2D, the standard histomorphometric parameters, fractal dimension, mean intercept length, and connectivity were computed. In 3D, histomorphometric parameters were computed using both the 3D mean intercept length method and model-independent techniques. The 3D fractal dimension and the 3D connectivity, assessed by Euler density, were also evaluated. The cubic samples were subjected to elastic compressive tests in three orthogonal directions (X, Y, Z) close to the main natural trabecular network directions. A test was performed until collapse of trabecular network in the main direction (Z). The mechanical properties were significantly correlated to most morphological parameters resulting from 2D and 3D analysis. In 2D, the correlation between the mechanical strength and bone volume/tissue volume was not significantly improved by adding structural parameters or connectivity parameter (nodes number/tissue volume). In 3D, one architectural parameter (the trabecular thickness, Tb.Th) permitted to improve the estimation of the compressive strength from the bone volume/tissue volume alone. However, this improvement was minor since the correlation with the BV/TV alone was high (r=0.96). In conclusion, which is in agreement with the statistic's rules, we found, in this study, that the determination of the os calcis bone compressive strength using the 3D bone volume fraction cannot be improved by adding 3D architectural parameters.

The degree of mineralization is a determinant of bone strength: a study on human calcanei.

Strength of bones depends on bone matrix volume (BMV), bone microarchitecture, and also on the degree of mineralization of bone (DMB). We have recently shown in osteoporotic patients treated with alendronate that fracture risk decreased and bone mineral density increased with a parallel increase of the DMB due to prolonged secondary mineralization but without modifications of BMV or bone microarchitecture. DMB and strength were both measured at the tissue level in calcaneus bone samples taken at autopsy from 20 subjects (aged 78 +/- 8 years, 8 women, 12 men) who died suddenly without apparent bone disease. DMB parameters measured on microradiographs (mean DMB, distribution of DMB, most frequent maximum DMB value, and width at half maximum, an index reflecting the homogeneity of DMB) were compared with those reported in iliac cancellous bone samples of 43 human bones. Histomorphometric measurements of microarchitectural parameters (TbTh, TbN, and TbSp) were also measured. Compression tests were performed on contiguous samples of the same calcaneus on a universal screw-driven machine (Schenck RSA 250). A 5000-N load cell (TME, F 501 TC) measured the compressive load. The displacement was measured directly on the sample using a specific displacement transducer developed by the <> The apparent Young's modulus (E), the maximal strength (sigma(max)), and the work (W) until failure were measured. In human cancellous bone tissue, mean DMB (+/- SD) was higher in calcaneus (1.135 +/- 0.147 g/cm(3)) than in iliac crest (1.098 +/- 0.077 g/cm(3)). The mean most frequent maximum DMB values (mean DMB freq. max.) were 1.118 +/- 0.175 g/cm(3) in calcaneus and 1.108 +/- 0.095 g/cm(3) in iliac samples, and DMB was more heterogeneous in calcaneus than in iliac samples (mean width at half maximum were 0.270 +/- 0.127 versus 0.227 +/- 0.056 g/cm(3), respectively). Compression tests revealed significant positive linear correlations between DMB and both elastic modulus (r(2) = 0.69) and maximal strength (r(2) = 0.69). Correlations with DMB persisted (P < 0.003) even after adjustment for both calcified bone volume, for the Young's modulus (E), the maximal strength (sigma(max)) (r(2) = 0.44 and 0.41, respectively), and microarchitectural parameters (0.50 < r(2) < 0.56, P < 0.001). The same results were obtained with the work to fracture (W) (0.23 < r(2) < 0.46, P < 0.045). We conclude that the more the cancellous tissue was mineralized, the higher was its stiffness and compressive strength. This may explain the increase in bone strength when DMB is modified in a physiological range without necessary changes of BMV and bone microarchitecture. The impact of such modifications on fracture risk and the therapeutic implications of these data remain to be analyzed.

[Variability of muscular and articular forces of the thumb. Comparison of three results during lateral grip]. / Variabilité des forces musculaires et articulaires de la colonne du pouce. Résultats comparés de trois études lors d'un geste de pince latérale.

The aim of this paper is to describe three different laboratory studies of muscular and articular forces in the thumb and to compare and discuss their results in term of constraints (forces and moments) at the carpometacarpal joint during key pinch. Imaging techniques such as biplanar roentgenograms or computer tomography imaging were used on cadaver hands and magnetic resonance imaging on living hands in order to determine bone dimensions, muscle and tendon forces, directions, and centres of rotation. Mechanical models of free bodies with three to five links were created. Problems of balancing of static forces were solved using different methods (electromyography, systematic combination of muscular forces or optimization method). The results in terms of muscular forces or constraints at the carpometacarpal joint showed a strong variability (one to three depending on method and hypothesis). However the three studies all showed subluxation of the carpometacarpal joint balanced by joint constraints. Finally, it was demonstrated using magnetic resonance imaging, that results were strongly influenced by the exact point of application of the forces.

[In vivo cinematic study of the trapezometacarpal joint]. / Etude cinématique in vivo de l'articulation trapézométacarpienne.

The aim of this study was to assess the trapeziometacarpal joint kinematics from in vivo measurements, both quantifying the ranges of motion and suggesting a suitable joint model. A motion analysis system has been used to collect the spatial trajectories of markers, glued respectively on the thumb and on the hand's palm. A rigorous protocol was set up to make sure of the trapezoid bone's fixity relatively to the hand, and then to be able to characterize the movement of the first metacarpus with respect to the trapezium. The ranges of motion have been measured on two distinct movements: circumduction and flexion-extension, and different types of joints: healthy, pathological and prosthetic. The joint axes of rotation (for flexion-extension and ante-retroposition movements) have been determined on healthy subjects. The computation of rotation amplitudes and positions of joint axes was based upon the finite helical axis concept, which degenerates into finite rotation axis when translations can be neglected. Both the measurement protocol and the calculation method have been validated by comparing the computed joint center with that measured on a radiography, in the case of a spherical prosthesis. The ranges of motion obtained on the healthy subject series were consistent with values published by other authors. Comparisons have been realized between these reference joints and different cases: arthrodesis, arthrosis and prosthesis. The determination of rotation axes of a normal joint has lead to a generalized cardan joint, i.e. two non perpendicular converging rotation axes.

[Total trapezometacarpal prostheses: concepts and classification study]. / Prothèses totales trapézométacarpiennes: concepts et essai de classification.

This paper is an attempt to classify the different types of trapezio-metacarpal total prostheses according to their bio-mechanical principle and to compare the bio-mechanics of these prostheses to that of the normal trapeziometacarpal joint. The trapeziometacarpal joint has two approximate centres of rotation (one in the proximal metacarpal, one in the trapezium), two degrees of freedom and two arc of mobility about 70 degrees. The mechanical model of the trapeziometacarpal joint is a universal-joint called "cardan" with three constraint forces (one axial compression force, and two shear forces, radial and posterior) and one constraint moment around the longitudinal axis. The trapeziometacarpal prostheses may be classified in two main categories: the most frequently used are the "ball and socket" prostheses. Several prostheses, including the surface replacement prostheses have the mechanical characteristics of an universal joint (cardan). Ball and socket prostheses have one centre of rotation, 3 degrees of freedom, three constraint forces in three directions and no constraint moment when "cardan" or surface prostheses have two centres of rotation and 2 degrees of freedom; three constraint forces and one constraint moment. Trapeziometacarpal prostheses may also be classified according to their arc of mobility, or according to their mode of primary fixation (cemented, non-cemented), "press-fit", expansion and to their secondary fixation (hydroxyapatite).

[Comparison of primary trapezometacarpal cup fixation using mechanical tests]. / Comparaison de l'ancrage primaire de cupules trapézométacarpiennes par tests mécaniques.

INTRODUCTION: In order to optimise the primary fixation of the cup of the Arpe (Biomet Merck) trapeziometacarpal prosthesis, several geometries have been studied. The mechanical strengths of the primary fixations ensured by cup "with slots", "bladed" and "with crown", have been assessed and compared to the one obtained for the primary anchorage of the Arpe cup. METHOD: For each cup, the strength of the primary fixation has been assessed in torsion (torque along the cup axis) and bending (torque perpendicular to the cup axis). Tests have been performed on prototype cups set up in a vertebral body of lamb cancellous bone. Torque recording allowed the assessment of the maximum strength for each cup type. RESULTS: Arpe and cup "with slots" showed an effective bending strength, respectively due to the three anchorage picks and to the equatorial over-thickness. However, the cup "with crown" demonstrated a better bending strength with a mean torque of pulling out Cbending = 0.89 Nm. In torsion, the three anchorage picks of the Arpe cup did not allow a solid anchorage. For such a loading, the cup "with crown" also showed the best torsion strength with a mean unsealing torque Ctorsion = 0.83 Nm. DISCUSSION: The equatorial over-thickness seems to give good bending and torsion strengths to the "bladed" and "with crown" cups, with a press-fit effect. Replacing the fixation points of the Arpe cup by a crown also allowed the improvement of its torsion strength.

High-resolution computed tomography for architectural characterization of human lumbar cancellous bone: relationships with histomorphometry and biomechanics.

The aim of the present study on human vertebral cancellous bone was to validate structural parameters measured with high-resolution (150 microm) computed tomography (HRCT) by referring to histomorphometry and to try to predict mechanical properties of bone using HRCT. Two adjacent vertical cores were removed from the central part of human L2 vertebral body taken after necropsy in 22 subjects aged 47-95 years (10 women, 12 men; mean age 79 +/- 14 years). The right core was used for structural analysis performed by both HRCT and histomorphometry. Two cancellous bone specimens were extracted from the left core: a cube for HRCT and a compression test, and a cylinder for a shear test. Significant correlations were found between HRCT and histomorphometric measurements (BV/TV, trabecular thickness, separation and number, and node-strut analysis), but with higher values for most of the tomographic parameters (BV/TV and trabecular thickness determined by HRCT were overestimated by a factor 3.5 and 2.5 respectively, as compared with histomorphometry). The maximum compressive strength and Young's modulus were highly correlated (rho = 0.99, p<0.0005). Significant correlation was obtained between bone mineral density (determined using dual-energy X-ray absorptiometry) and the maximum compressive strength (rho = 0. 64, p = 0.002). In addition the maximum compressive strength and architectural parameters determined by HRCT or histomorphometry showed significant correlations (e.g., for HRCT, BV/TV: rho = 0.88, p<0.0005, N.Nd/TV: rho = 0.73, p<0.001). The shear strength was significantly correlated with BV/TV (rho = 0.62, p = 0.002), Tb.Sp (rho = -0.58, p = 0.004) and TSL (rho = 0.55, p = 0.006) measured by HRCT. In conclusion, an HRCT system with 150 microm resolution is not sufficient to predict the true values of the structural parameters measured by histomorphometry, although high correlations were found between the two methods. However, we showed that a resolution of 150 microm allowed us to predict the mechanical properties of human cancellous bone. In vivo peripheral systems with such a resolution should be of interest and would deliver an acceptable radiation dose to the patient.

[Comparative biomechanical study of 3 types of osteosynthesis of the Duparc grade IV fractures of the calcaneus: value of triangular internal fixation]. / Etude biomécanique comparée de 3 ostéosynthèses des fractures enfoncements du calcaneum stade IV de Duparc. Intérêt du montage en triangulation.

PURPOSE OF THE STUDY: We present an in vitro biomechanical study performed to evaluate and compare, for an experimentally produced fracture of the calcaneum (Duparc grade IV), the reaction of 3 standard models of internal fixation commonly used in these fractures and which occupy different volumes. MATERIALS AND METHODS: We compared different methods of fixation using fresh human calcanei. In two experimental series, we compared triangular internal fixation (3 1/4 tube AO plates Saragaglia), Y internal fixation (2 1/3 tube AO plates Bezes), isolated screw technique (three 3.5 diameter screws, two 4.5 diameter screws). The plates and screws were made of identical material (316L). Both series used 8 pairs of bone (talo-calcaneum system) with the same fracture submitted to a 200N to 1000N load. Stiffness and movement were analyzed using 8 references on the calcaneum. RESULTS: The stiffness and movement analysis with 8 references points demonstrated the superior resistance to bending with the triangular internal fixation. Fixation stability was significantly better than with the Y or screw technique. DISCUSSION: This study underlined the importance of triangular trabecular organization of cancellous bone on calcaneum biomechanics. We showed that the 3 (anterior, posterior and inferior) trabeculae must be repaired in calcaneum fractures to achieve horizontal and vertical stability of the talar joint. CONCLUSION: In our hands, restoration of the triangular architecture of calcaneum fractures, to resemble a roof truss, where the talus is fixed to the triangle vertex, is fundamental to obtain a rigid and stable internal fixation.

Mechanical characterization in shear of human femoral cancellous bone: torsion and shear tests.

In order to investigate and compare the mechanical behaviour of human cancellous bone during different shear loading modes, two tests were performed to characterise human femoral cancellous bone in shear: a torsion test until failure and a shear test using a sharpened stainless steel tube. Paired cylindrical samples were core drilled from 12 human femoral heads, symmetrically with respect to the coronal plane and along the primary trabecular direction. The distal part of the sample was assigned to a torsion test and the shear test was performed on the proximal part along two perpendicular anatomical directions. Apparent densities and tissue densities were measured on both torsion and shear specimens. The mean torsion properties were shear modulus G, 289 (183) MPa, ultimate stress tau(torsion), 6.1 (2.7) MPa, ultimate strain gamma(ultimate), 4.6 (1.3)%, yield stress tau(yield), 4.3 (1.9) MPa and yield strain gamma(yield), 1.8 (0.3)%. Strong correlation was obtained between G and tau(torsion) (r'=0.853, p<0.001). These torsion properties were correlated with apparent density of torsion specimens showing, respectively: r'=0.713, p=0.005 and r'=0.671, p=0. 008. Properties from the shear test were invariable with regard to the two tested directions then isotropic ultimate shear stress and isotropic elementary shear stress, which represent the mean values of the two tested directions were, respectively, tau(shear), 10.0 (4. 5) MPa and tau(elem), 18.8 (6.1) MPa. Both shear stresses were correlated with apparent density of shear specimens: tau(shear), r'=0.564, p=0.045 and tau(elem), r'=0.636, p=0.024. Apparent densities for shear specimens were superior than for torsion specimens (p=0.06) and the comparison was the opposite for tissue densities (p=0.028), showing strong density gradients of cancellous bone in the femoral head. These torsion and shear tests which permit the evaluation of cancellous bone behavior under two different types of shear loading, may be performed on different human sites and the measured shear properties may be compared to structural properties of cancellous bone.

Mechanical properties of ewe vertebral cancellous bone compared with histomorphometry and high-resolution computed tomography parameters.

The goal of the present study was to determine if a high-resolution computed tomography (HRCT) system with 150 microns resolution was sufficient to predict mechanical properties in ewe lumbar vertebrae. To answer this question, we used a triangular comparison between: HRCT; biomechanics (compression and shear tests); and histomorphometry, which was the reference method for the measurements of morphometric parameters. Two dissected lumbar vertebrae (L-4 and L-5) from 32 ewes were used. Both compressive and shear properties correlated significantly with amount of bone and structural parameters evaluated by histomorphometry (bone volume/tissue volume, trabecular thickness, trabecular separation), but no significant correlation was found with the trabecular number. With our shear test involving the trabecular architecture itself more significant correlations were found with the node-strut analysis parameters than from the compressive test. Significant correlations were also found between HRCT and histological parameters (bone volume/tissue volume, bone surface/bone volume, trabecular separation, trabecular number, total strut length, number of nodes, and number of termini). Correlations between HRCT structural parameters and mechanical properties on L-4 were of the same magnitude as the correlations between the histomorphometric structural parameters and mechanical results on L-5 but with the remarkable advantage the HRCT is a noninvasive method. In spite of the resolution (150 microns) of our HRCT system, which entailed mainly an enlargement of the thinnest trabeculae or their loss during the segmentation process, we obtained coherent relationships between mechanical and tomographic parameters. The thinnest trabeculae probably had little effect on the mechanical strength. Also, this type of resolution allows us to consider the possibility of perfecting an in vivo HRCT system. However, physical density and bone mineral density correlated much better with strength than either classical histomorphometric or tomographic parameters. The current conclusion is fairly negative with respect to the ability of HRCT to assess mechanical properties nondestructively as compared with dual-energy X-ray absorptiometry. But, the noninvasive nature of the imaging modality and the capacity for three-dimensional imaging at arbitrary orientation make HRCT a promising tool in the quantitative assessment of cancellous architecture.

The effects of density and test conditions on measured compression and shear strength of cancellous bone from the lumbar vertebrae of ewes.

An animal model (the ewe) was used to study mechanical parameters of cancellous bone specimens. Compression and shear tests were conducted on ewe vertebral trabecular bone (L1-L5) from old ewes (mean age: 9 years) under two different conditions: first, at room temperature in air ("standard" test conditions); and secondly, in a physiological saline bath regulated at 37 degrees C. The parameters obtained under "standard" test conditions with a uniaxial compression test were the mean value of the maximum strength (sigma max = 22.3 (7.06) MPa), Young's modulus (E = 1510 (784) MPa), the strain at maximum strength (epsilon sigma max = 3.21 (0.8) percent) and the energy absorbed during the test (W = 0.3 (0.12) MJ.m-3). No significant change was found when the test was carried out in a saline bath at 37 degrees C (p < 0.0005). An original shear test was performed to evaluate the shear strength which was found to vary from 7.5 (4.7) to 14.6 (8.53) MPa under "standard" test conditions depending on the method of calculation. Testing of the specimens in a 37 degrees C physiological saline bath induced a decrease in the shear strength from 32.5 percent (p < 0.0005) to 37.3 percent (p < 0.0001) of those measured under "standard" test conditions. The non-destructive measurement of the Bone Mineral Density (BMD) accounted for up to 73.3 percent of the maximum compressive strength sigma max and 61.5 percent of the maximum shear strength tau max determined in saline solution at 37 degrees C. These results showed that other parameters influencing the mechanical properties of trabecular bone and its structure appeared to be essential.

[Biomechanical comparative study of three types of osteosynthesis in the treatment of supra and intercondylar fractures of the humerus in adults]. / Etude biomécanique comparative de trois types d'ostéosynthèse pour les fractures sus et intercondyliennes de la palette humérale de l'adulte.

PURPOSE OF THE STUDY: Supra and intercondylar fractures are the most common fractures of the distal end of the humerus in adult. An osteosynthesis consisting of a plate is the treatment of choice. But location and type of plate always remain open for debate. The authors present the results of an in vitro biomechanical study, which compared the stiffness of three types of osteosynthesis commonly used in these fractures. MATERIAL AND METHODS: The devices were on one hand the premolded lateral plate of Lecestre and Dupont (Howmedica) used alone or in conjunction with a medial 1/3 tubular plate of the AO group, and on the other hand a posterior plate, of which we are developing a new model, the Lambda plate (Protek) "Y"-shaped, monoblock, flat and molded on the humerus during operation. The study compared these different methods of fixation on fresh human humeri. In a first part, the posterior plate was compared to the single lateral one; in a second part, the posterior plate was compared to the coupled lateral and medial plates. The three plates were made of identical material. Both studies used eight pairs of bones with supra and intercondylar fractures realized by sawing. Each bone of a pair was fixed with one of the two types of device. Each humerus underwent different loading forces; sagittal bending (anterior and posterior) and torsion. The displacements were recorded using a calibrated measuring device coupled to two displacement sensors. The stiffness was calculated on force/displacement curves. RESULTS: In anterior bending, the Lambda posterior fixation was significantly stiffer than the single lateral one (p < 0.05) (239 +/- 109 versus 129 +/- 65 N/mm), and was not significantly different of the bilateral fixation (229 +/- 93 versus 224 +/- 108 N/mm). In posterior bending, the mean stiffness of the Lambda fixation was not significantly different to that of the lateral fixation (91 +/- 27 versus 91 +/- 52 N/mm), and less than that of the bilateral one (130 +/- 39 versus 170 +/- 70 N/mm), but not significantly. In torsion the mean stiffness of the Lambda fixation was superior to that of the lateral one (146.75 +/- 50.66 versus 119.75 +/- 58.8 Nm/rad), and bilateral one (233.31 +/- 107.47 versus 212.31 +/- 113.55 Nm/rad), but again not significantly. DISCUSSION: The ideal osteosynthesis for the fractures of the humeral distal doesn't exist, because the bone undergoes antero-posterior and posteroanterior cyclical forces during elbow flexion. Therefore the best device should be placed on both sides of the bone, but anatomical reasons make this location impossible. According to our study, we think the "less worst" device is the posterior one using the Lambda plate. Its symmetrical design allows a best loading distribution on the two columns. Its thickness compensates for its posterior location and the short interval between two holes allows to put many screws (4 to 6) into the epiphysis. All supra and intercondylar fractures, comminuted or not, can be treated with this material. The single lateral device isn't still enough. Its stiffness mainly depends on the orientation of the oblique screw in the medial column. But the design of this column doesn't always allow for an optimal location of the screw, which is the reason of several failures. The bilateral device gives a stiffness, comparable to the posterior one, but doesn't allow as many screws as the Lambda plate in the epiphysis. Therefore, it can't be used in very distal fractures. CONCLUSION: In spite of the progress of the material and the accuracy of the indications, the treatment of supra and intercondylar fractures of the distal end of the humerus is always a difficult problem. The devices have to be as stable as possible to allow an early motion. The best one should be placed on both sides of the distal humerus, because of the sagittal cyclic forces it undergoes, but this location is anatomically impossible. Our study concludes that the device using the Lambda plate i

Experimentally induced ulno-carpal instability. A study on 13 cadaver wrists.

This experimental work studies the role of ligamentous structures in suspending the carpal bones from the radius and ulna. Thirteen human cadaver wrists underwent a distal radio-ulnar arthrodesis in a neutral position and an arthrodesis between the three bones of the first carpal row. Progressive postero-anterior forces in a palmar direction were applied to the fused carpal bones. Displacement was measured by two dial gauges before and after sequential section of the different fibrous structures. The largest absolute average displacement (both, dorso-palmar and induced rotational displacement) was observed after section of the ulnar styloid process. No significant differences were observed after section of the extensor retinaculum, extensor carpi ulnaris sheath, posterior ulno-carpal and posterior radio-carpal ligaments. This work suggests that the carpus is suspended not only from the radius, but also from the distal ulna and particularly at the ulnar styloid and the structures which insert onto it.

Evolution during growth of the mechanical properties of the cortical bone in equine cannon-bones.

Two specimens (70.0 x 4.5 x 1.8 mm) (proximal and distal) of cortical bone were taken from each of the cranial, caudal, lateral and medial quadrants at mid-diaphysis of the third metacarpus and metatarsus of French saddle horses (12 males and seven females) aged from 1 day to 4 years. The mechanical properties (bending strength, Young's modulus, yield stress and ultimate specific deflection) were determined by a 4-point bending test, loading at a rate of 166 x 10(-6) ms-1. During growth, the mechanical properties of the cortical bone were not significantly different (p > 0.05) between metacarpus and metatarsus, but they were slightly higher in the proximal than in the distal diaphysis. The variations in these properties were significant (p < 0.0001) between quadrants. From birth to adult age, the lateral and medial quadrants had greater average bending strength (Sb = 226 +/- 27 MPa), average Young's modulus (E = 16 +/- 2 GPa) and average yield stress (Sy = 110 +/- 23 MPa) than the cranial quadrant (Sb = 209 +/- 23 MPa, E = 15 +/- 2 GPa, Sy = 99 +/- 18 MPa) while the caudal quadrant gave the lowest values (Sb = 195 +/- 30 MPa, E = 14 +/- 2 GPa, Sy = 92 +/- 21 MPa). During the growing period, the bending strength, the Young's modulus and the yield stress were positively correlated with age (p < 0.01) and the total body weight (p < 0.001) of the horses. Conversely, the ultimate specific deflection decreased slightly during the same period. The mechanical properties of the cortex were also related (p < 0.005) to the mineral content (ash or calcium). The Young's modulus was particularly correlated to calcium content (p < 0.0001). It is also linearly related to the bending strength (r = 0.8), and its in vivo determination by the ultrasound method should provide an easy and non-invasive investigation means of the mechanical properties of the cortical bone in equine cannon-bones.

Comparison between bone density and bone strength in glucocorticoid-treated aged ewes.

In order to assess if bone densitometry could be used as an indicator to evaluate bone fragility in short term studies performed on glucocorticoid-treated ewes, correlations between DXA measurements and biomechanical parameters obtained on the same bones were established in 27 aged ewes including sixteen animals treated with methylprednisolone 15 mg/day for 4 months and eleven untreated animals. DXA measurements were performed ex-vivo on HOLOGIC QDR-1000+ device. Biomechanical testings included a three-point bending test on the femur and a compression test on cylinders of cancellous bone excised from two lumbar vertebrae selected between L6 and L4. At the femoral site, bone mineral density was correlated with the bending stiffness (r = 0.65) and the ultimate bending strength (r = 0.64) whereas, at the vertebral site, biomechanical parameters failed to correlate with bone mineral density assessed by DXA. This apparent lack of correlation between vertebral bone mass and trabecular bone strength is mainly linked to anatomical characteristics of the ewe: in this species, the vertebral posterior arches, which consist mainly of cortical bone, are very large compared to the vertebral body and strongly influence the bone mineral density evaluated on the intact vertebra. This is not the case with other large animals, for instance non-human primates. In conclusion, DXA can give a good evaluation of bone strength for ewe femurs, but results must be interpreted carefully at the vertebral site due to the anatomical characteristics of this animal species.