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1.
Biomed Res Int ; 2018: 8503427, 2018.
Article in English | MEDLINE | ID: mdl-30519588

ABSTRACT

Traumatic, neoplastic, inflammatory, or infective dental removal promotes a gradual resorption process of bone which leads to a "nonuse" atrophy of the alveolar ridges. Many techniques allows restoring an appropriate bone thickness, but nowadays the attention is focused on the use of natural or synthetic grafts. Numerous studies have been conducted to develop and test new synthetic materials. In this article, the authors report their experience using a synthetic bone substitute in combination with Platelet Rich Fibrin (PRF). This technique was applied in different zones of the maxillomandibular district. The procedure showed a very satisfying bone regeneration without important complications.


Subject(s)
Alveolar Process/surgery , Bone Regeneration/physiology , Bone Substitutes/therapeutic use , Guided Tissue Regeneration, Periodontal/methods , Platelet-Rich Fibrin/metabolism , Adolescent , Adult , Aged , Alveolar Process/metabolism , Child , Female , Humans , Jaw Fixation Techniques , Male , Middle Aged , Young Adult
2.
Eur J Histochem ; 60(2): 2605, 2016 Jun 13.
Article in English | MEDLINE | ID: mdl-27349311

ABSTRACT

Unilateral posterior crossbite is a widespread, asymmetric malocclusion characterized by an inverse relationship of the upper and lower buccal dental cusps, in the molar and premolar regions, on one side only of the dental arch. Patients with unilateral posterior crossbite exhibit an altered chewing cycles and the crossbite side masseter results to be less active with respect to the contralateral one. Few studies about morphological features of masticatory muscle in malocclusion disorders exist and most of these have been performed on animal models. The aim of the present study was to evaluate morphological and protein expression characteristics of masseter muscles in patients affected by unilateral posterior crossbite, by histological and immunofluorescence techniques. We have used antibody against PAX-7, marker of satellite cells, and against α-, ß-, γ-, δ-, ε- and ζ-sarcoglycans which are transmembrane glycoproteins involved in sarcolemma stabilization. By statistical analysis we have evaluated differences in amount of myonucley between contralateral and ipsilateral side. Results have shown: i) altered fibers morphology and atrophy of ipsilateral muscle if compared to the contralateral one; ii) higher number of myonuclei and PAX-7 positive cells in contralateral side than ipsilateral one; iii) higher pattern of fluorescence for all tested sarcoglycans in contralateral side than ipsilateral one. Results show that in unilateral posterior crossbite hypertrophic response of contralateral masseter and atrophic events in ipsilateral masseter take place; by that, in unilateral posterior crossbite malocclusion masticatory muscles modify their morphology depending on the function. That could be relevant in understanding and healing of malocclusion disorders; in fact, the altered balance about structure and function between ipsilateral and contralateral muscles could, long-term, lead and/ or worsen skeletal asymmetries.


Subject(s)
Malocclusion/metabolism , Masseter Muscle/metabolism , PAX7 Transcription Factor/metabolism , Sarcoglycans/metabolism , Sarcolemma/metabolism , Adolescent , Adult , Female , Humans , Male , Malocclusion/pathology , Masseter Muscle/pathology
3.
Eur J Histochem ; 60(4): 2642, 2016 Dec 06.
Article in English | MEDLINE | ID: mdl-28076936

ABSTRACT

Bone graft are used in dentistry for the reconstruction of severely atrophic jaws. Fresh frozen bone has no osteogenic property but it has osteoconductive and osteoinductive properties because its matrix contains growth factors such as vascular endothelial growth factor. The purpose of the present study was to evaluate morphological and protein expression characteristics of fresh frozen bone before graft and after six months of graft in patients who needed maxillary reconstruction. After 6 month of graft we observed the presence of viable bone as evidenced by full osteocyte lacunae and by the presence of RANKR, osteocalcin positive cells and vascular endothelial growth factor. In conclusion, our findings show that the fresh frozen bone after six month of graft is for the most part viable bone, encouraging its use as an alternative to autogenous bone for reconstructing maxillary bone defects prior to implant.


Subject(s)
Bone Transplantation , Cryopreservation , Maxilla/cytology , Maxilla/metabolism , Female , Humans , Male
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