[Osteomyelitis following BCG vaccination]. / Osteomyelitis nach BCG-Impfung.

Typical for the case history of a patient with the very rare vaccination-induced osteomyelitis is a relatively long interval between the BCG-vaccination and the initial clinical symptoms. The course of the disease is undramatic. Pronounced changes are frequently visible in x-rays and, with proper surgical and tuberculostatic therapy, the prognosis is good as well. The morphological changes in cases of BCG-osteomyelitis cannot be distinguished from those caused by tuberculosis. The same causal factors as for other possible BCG-complications are considered pathogenically significant for its development, perhaps as a result of a local trauma, too. When a BCG-osteomyelitis is suspected clinically, a curettage of the affected bone tissue is indicated for diagnostic as well as therapeutic purposes. A cause of BCG-osteomyelitis, diagnosed in a three-year-old girl, was described causally in detail.

[Benign chondroblastoma]. / Benigní chondroblastom.

Analysis of 12 observations with a typical histological appearance revealed only in one case a local relapse. In two tumours the authors found a structure encountered in aneurysmatic osseous cysts and in one case, due, to the presence of a major number of osteoclasts, the differential diagnosis with a giant-cell bone tumour was rendered more difficult. Electron microscopic examination revealed that tumours of this type are formed by cartilage cells differentiated in different ways. In cellular areas two main types of cells are found: light and dark ones. Some of the elements of both types had multilobular nuclei.