ABSTRACT
Six hundred twenty-three pregnant women with iron deficiency anemia received iron dextran Imferon by total dose infusion (TDI). Two dose levels were compared in respect of tolerance and hemoglobin response. The incidence of delayed reactions was significantly higher in the high dose group (P less than 0.01) but there was no significant difference in the incidence of reactions occurring during the infusion. These findings are discussed in relation to the hemoglobin response.
Subject(s)
Anemia, Hypochromic/drug therapy , Iron-Dextran Complex/adverse effects , Pregnancy Complications, Hematologic/drug therapy , Adolescent , Adult , Clinical Trials as Topic , Dose-Response Relationship, Drug , Female , Humans , Infusions, Intravenous , Iron-Dextran Complex/administration & dosage , Iron-Dextran Complex/therapeutic use , Pregnancy , Pregnancy Outcome , Random AllocationABSTRACT
PIP: This study was designed to determine the prevalence of significant bacteriuria in pregnancy in Dar es Salaam as well as attempt to find out whether bacteriuria has any effects on the mother and baby. Of 1007 pregnant women studied for asymptomatic bacteriuria, a significant bacteriuria rate of 6.3% was revealed. Escherichia coli was the predominant organism, making up 47.6% of the total organisms isolated. Schistosoma hematobium was present in 8.7%, T. vaginalis in 14%, yeast cells were found in the urine of 9.1% and the microfilariae of Wuchereria bancrofti were found in 1 specimen. 66.2% had no abnormality in their urine. It is recommended on the basis of this study that all women found to have significant bacteriuria in 1 cultured urine sample should be treated. There was a significant relationship noted between significant bacteriuria and the passing of S. hematobium in the urine. There was also a significant correlation between the presence of T. vaginalis and yeast cells in the urine. On the basis of laboratory sensitivity studies it was also found that the antimicrobial agents of choice for treating urinary tract infections in Dar es Salaam where E. coli and Klebsiella erogenes are the predominant organisms are nitrofurantoin, nalidixic acid and co-trimoxazole. The socioeconomic status of the bacteriuric and control group was divided into 4 groups according to take home pay; results show no significant increase of bacteriuria in any of the groups. It was not possible to follow up the effects of the presence of micro-organisms in urine during pregnancy because once a woman was found to have a positive culture she was treated.^ieng
