ABSTRACT
A heterocyclic compound, pyridine-2-carbaldehyde thiosemicarbazone (HFoTsc), and its six metal coordinated bound complexes, three with platinum (II) and three with palladium (II), were studied for their activity against herpes simplex virus 1 (HSV-1) infection in cultured cells. According to their cytotoxicity the compounds were divided into two groups. Group I (cytotoxic compounds) included all three palladium complexes and [Pt(HFoTsc)2] Cl2, with maximum non-toxic concentration (MNC) of 1-10 micromol/l and a 50% cytotoxic concentration (CC50) of 20-100 micromol/l. Group 2 (low cytotoxic compounds) with MNC of 100 micromol/l and CC50 of 548-5820 micromol/l included compounds in the following order: [Pt(HFoTsc)2] Cl2Subject(s)
Antiviral Agents/pharmacology
, Herpesvirus 1, Human/drug effects
, Organometallic Compounds/pharmacology
, Organoplatinum Compounds/pharmacology
, Palladium/pharmacology
, Thiosemicarbazones/pharmacology
, Animals
, Cattle
, Cell Line
, Cytopathogenic Effect, Viral/drug effects
, Dose-Response Relationship, Drug
, Herpesvirus 1, Human/growth & development
, Inhibitory Concentration 50
, Structure-Activity Relationship
, Time Factors