ABSTRACT
The goal of this study was to investigate the effect of selenium deficit replenishment in patients with bronchial asthma (BA) on manifestations of oxidative stress and conditions of the antioxidant system (AOS). The need of correction of selenium deficit in BA-patient is determined by the increased needs in antioxidants due to chronic inflammatory process responcible for pathogenesis of BA. Latvia and also Eastern Finland, Byelorussia, some regions of Ukraine, some regions of the NorthWestern Russia, New Zealand belong to endemic areas with marked selen deficit in soils and foodstuff. Twenty patients (7 men and 13 women) with selen deficit and verified diagnosis of BA have been examined. In addition to basic therapy all patients received organic selenium SelenoPRECISE, ("PharmaNord") 200 microg daily for 16 weeks. This caused statistically significant increase of plasma selenium from 50.94+/-7.58 microg/l to 63.59+/-10.87 microg/l (p<0.001), the increase of selenium-dependent glutathione peroxidase (from 38.64+/-10.72 U/g Hb to 58.57+/-14.64 U/g Hb, p<0.001). Treatment of patients with selenium also normalized parameters charecterizing oxidative stress (chemiluminescence). The use of selenium in addition to basic therapy allows to abolish or alternate manifestations of oxidative stress by correcting the antioxidant system.
Subject(s)
Asthma/drug therapy , Oxidative Stress/drug effects , Selenium/therapeutic use , Asthma/metabolism , Catalase/blood , Female , Glutathione Peroxidase/blood , Humans , Lipid Peroxidation/drug effects , Male , Prospective Studies , Selenium/deficiency , Selenium/pharmacologyABSTRACT
The authors present data on air pollution in medical establishments of Riga. The average concentrations of chemicals do not exceed the MACs in hospital compartments. Short-term concentrations of some chemicals in operating rooms and laboratories are considerably higher than the corresponding normal values. Doctors' offices appeared to have increased bacterial contamination. The calculated exposure for chemical mixture was recommended for risk evaluation.
Subject(s)
Hazardous Substances/adverse effects , Hazardous Substances/analysis , Health Personnel , Health Status , Occupational Diseases/etiology , Occupational Exposure/adverse effects , Occupational Health , Humans , Occupational Diseases/prevention & control , Occupational Health/legislation & jurisprudence , Risk FactorsABSTRACT
Photometric procedures of monitoring the content of adenine synthesis intermediate products were developed and optimum conditions of air sample analysis and selection determined. Thus it became possible to establish general exposure levels for (phenylazo) malondinitryl and 4,5,6 triaminopyrimidine sulfate, sensitivity of determination being 0.25 mg/l.
