ABSTRACT
In order to assess the morphohistochemical state of the liver after pulmonectomy the liver structure of 25 mature dogs was studied within 3 months after resection of one lung by a conventional method. The authors make a conclusion that changes in the liver resulting from extensive resection of one lung can be prevented by measures eliminating stagnation in the venous system of the large circulation circuit.
Subject(s)
Hypertension, Pulmonary/etiology , Liver/pathology , Pneumonectomy , Postoperative Complications , Animals , Dogs , Hypertension, Pulmonary/pathology , Time FactorsABSTRACT
The oxygen-transport function of blood in hyperoxia and acute disturbances of the acid-alkali condition was studied in "oxygenator--desoxygenator" as a model. It has been established that in acidosis there occurs decreased intensity of glycolysis in erythrocytes, accumulation of 2,3 diphosphoglyceric acid which decreases affinity of hemoglobin for oxygen. It does not occur in alcalosis.
Subject(s)
Acid-Base Imbalance/blood , Acidosis, Respiratory/blood , Alkalosis, Respiratory/blood , Oxygen/blood , Acute Disease , Biological Transport , Carbon Dioxide/blood , Energy Metabolism , Erythrocytes/metabolism , Humans , Models, Structural , Oxyhemoglobins/metabolismABSTRACT
A model of acute respiratory insufficiency ARI was created in the experiments on 16 dogs by means of a valvular device furnishing a free inhalation and a limited expiration. The diaphragmatic oxigenator devised in VNIIP with an armoured diaphragm of "Sigma"--type was switched on at the height of ARI. 3 hours' perfusion corrected successfully the manifestation of hypercapnic hypoxia. The pulmonary function restored after the experiment.
Subject(s)
Oxygenators, Membrane , Respiratory Insufficiency/therapy , Acute Disease , Animals , Disease Models, Animal , Dogs , Hypercapnia/therapy , Hypoxia/therapy , Partial Pressure , Time FactorsSubject(s)
Lung Transplantation , Organ Preservation , Tissue Preservation , Humans , Hypothermia, Induced/methods , Ischemia/physiopathology , Lung/blood supply , Organ Preservation/methods , Perfusion/methods , Time Factors , Tissue Donors , Tissue Preservation/methods , Transplantation, HomologousABSTRACT
In the experiments on 20 dogs with the left-side pulmonectomy it has been shown that the removal of one lung results in a progressive rise of the pulmonary circulation blood pressure which, in turn, causes some changes in the structure of the lung and of its function in the lipid metabolism.
Subject(s)
Hypertension, Pulmonary/etiology , Lipids/blood , Lung/pathology , Pneumonectomy/adverse effects , Postoperative Complications/etiology , Animals , Dogs , Hypertension, Pulmonary/physiopathology , Postoperative Complications/physiopathology , Pulmonary Circulation , Time FactorsSubject(s)
Military Medicine , Warfare , Bulgaria , History, 19th Century , Humans , Red Cross , Russia (Pre-1917) , Turkey , Wounds, Gunshot/surgerySubject(s)
Plethysmography, Impedance/methods , Adolescent , Adult , Animals , Blood Flow Velocity , Dogs , Electric Conductivity , Electrodes , Hemorrhage/physiopathology , Humans , Lung/physiology , Middle Aged , Pulse , Regional Blood Flow , RespirationSubject(s)
General Surgery/history , History, 19th Century , History, 20th Century , Research , USSRABSTRACT
The dynamics of acute lung edema development caused by injection of oleic acid into the right heart chambers was traced experimentally on dogs by means of impedance plethysmography. The most of information was collected with the help of electrodes applied to the chest. The development of acute lung edema was followed by decrease of the impedance respiratory undulations and by changes in their characteristics.
Subject(s)
Plethysmography, Impedance/methods , Pulmonary Edema/etiology , Acute Disease , Animals , Dogs , Electrodes , Female , Hemodynamics , Male , Pulmonary Edema/physiopathology , Respiration, ArtificialABSTRACT
In experiments on 50 dogs with toxic acute edema of the lung, induced with intravenous injection of 0.1% silver nitrate, the authors have studied the efficacy of accessory artificial circulation and "conservative" therapy. During the perfusion a discharge of the right portions, adequate extracorporeal gas metabolism, normalization of blood gas and acid-base balance were noted; an intensity of pulmonary edema is descreased. An intensive therapy for pulmonary edema was found to be more effective in association of "conservative" treatment with venoarterial perfusion and blood oxygenation.
Subject(s)
Extracorporeal Circulation , Pulmonary Edema/therapy , Acid-Base Equilibrium , Acute Disease , Animals , Dogs , Follow-Up Studies , Hemodynamics , Oxygen/blood , Oxyhemoglobins/analysis , Pulmonary Edema/physiopathologyABSTRACT
The response of the pulmonary tissue in a continuous stay of foreign bodies in the lung is characterized by chronic inflammation of the pulmonary tissue, deformation of the bronchial tree, atrophic, hyperplastic and dystrophic changes in the ciliated epithelium and its metaplastic degeneration into multitratum squamous epithelium. Chronic inflammation of the lung would develop mainly in bronchial injury with a foreign body or in impaired bronchial patency. In localization of metallic foreign bodies extrabronchially their incapsulation usually occurs.
