[An antibiotic complex produced by Streptomyces werraensis 1365T strain]. / Antibioticheskii kompleks, obrazuemyi shtammom Streptomyces werraensis 1365 T.

An antibiotic complex comprising four components (A, B, C, and X) was extracted from a native solution and mycelium of Streptomyces werraensis 1365T. The components were purified by column and thin-layer (TLC) chromatographic procedures to study their physicochemical and biological properties. The results were used to identify the substances isolated. The preliminary data allowed us to identify the components X, A, and B as the previously described compounds undecylprodigiosin, anisomycin, and copiamycin, respectively, whereas component C is a natural compound, which probably has never been described.

[Development of a new method for preparing biologically active compounds based on the typed strain Streptomyces werraensis]. / Razrabotka novogo metoda polucheniia biologicheski aktivnykh soedinenii na osnove tipovogo shtamma Streptomyces werraensis.

The regulatory function of a DNA fragment responsible for actinomycin resistance in the typed strain Streptomyces werraensis ATCC 1365, which produces a macrotetrolide antibiotic, was studied. Metabolic changes made this strain capable of producing an antibiotic complex, which comprises four biologically active compounds absent from the parent culture.