1.
Eur J Pharmacol
; 151(1): 127-9, 1988 Jun 22.
Article
in English
| MEDLINE
| ID: mdl-3416920
ABSTRACT
In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to replicate the results of an earlier report and suggest that RO 15-4513 is unlikely to be clinically useful treating acute severe ethanol toxicity.