ABSTRACT
A case of an extensive arterial anomaly in the vertebral canal (Th5-S5) in a boy aged 3 years is described. Sudden onset of the disease with massive subarachnoid haemorrhage, loss of consciousness and signs of raised intracranial pressure suggested rather a lesion in the cranial cavity. The final diagnosis was made after myelography and spinal arteriography. In view of the extent of the lesion its radical removal was not possible. Embolization was done twice of the greatest vessels feeding the anomaly followed by decompression laminectomy. The patient is without neurological defects and pains. The case is reported in view of its rarity and atypical character of the lesion as well as its extent.
Subject(s)
Arteriovenous Malformations/complications , Sacrum/blood supply , Spinal Canal/blood supply , Spinal Cord Compression/etiology , Subarachnoid Hemorrhage/etiology , Thoracic Vertebrae/blood supply , Angiography , Arteriovenous Malformations/diagnostic imaging , Child, Preschool , Embolization, Therapeutic , Humans , Laminectomy , Male , Myelography , Sacrum/diagnostic imaging , Sacrum/surgery , Spinal Canal/diagnostic imaging , Spinal Canal/surgery , Spinal Cord Compression/diagnostic imaging , Spinal Cord Compression/surgery , Subarachnoid Hemorrhage/diagnostic imaging , Subarachnoid Hemorrhage/therapy , Thoracic Vertebrae/diagnostic imaging , Thoracic Vertebrae/surgeryABSTRACT
An examination of the migration ability of pool tissue and vascular granulocytes was performed in 60 patients and in 9 patients, the migration ability of bone marrow granulocytes. The test for granulocyte migration by Clausen, Bendixen and Søborg was performed with each granulocyte pool separately. It was proved that in patients with atopic asthma there is a significant statistical reduction in bone marrow and peripheral blood granulocyte migration during the asymptomatic period. During dyspnea, a decrease in migration of granulocytes from tissue and peripheral blood is seen.
Subject(s)
Asthma/immunology , Granulocytes/immunology , Adolescent , Adult , Bone Marrow/immunology , Cell Movement , Humans , In Vitro TechniquesABSTRACT
Sixty-five patients with atopic asthma, 54 with infectious asthma, and 30 healthy controls were evaluated by in vitro granulocyte migration and by the in vivo skin window method of Southam. Quantitative IgM, IgG, IgA, IgE serum concentrations were measured. In vivo migration of granulocytes was decreased in patients with atopic asthma and elevated levels of IgE as well as in patients with infectious asthma and elevated levels of IgG. In vivo migration of granulocytes showed significant decreases in both asthmatic groups only during asthmatic attacks.
Subject(s)
Asthma/immunology , Cell Migration Inhibition , Granulocytes/immunology , Dyspnea/immunology , Humans , Hypersensitivity, Immediate/immunology , Immunoglobulins/analysis , In Vitro Techniques , Skin Window TechniqueABSTRACT
Investigations were carried out on the ability of the granulocytes in the tissue pool and vascular pool of 50 healthy subjects to engulf latex particles and to reduce NBT in the test of Park as modified by the authors. In six subjects the investigation was carried out using bone marrow granulocytes. It was demonstrated that 0.2% of bone marrow granulocytes, 11% of vascular granulocytes and 93% of those in the tissue pool had the ability of NBT reduction. The ability to engulf neutral latex particles was exhibited by 6% of bone marrow granulocytes, 93% of those from the vascular pool, and 100% of those in the tissue pool.
Subject(s)
Granulocytes/physiology , Bone Marrow Cells , Humans , Latex , Microspheres , Nitroblue Tetrazolium/metabolism , Oxidation-Reduction , Phagocytosis , Tissue DistributionABSTRACT
Healthy children of atopically asthmatic parents received in vivo and in vitro granulocyte migration tests. Eleven children whose parents were both asthmatic showed statistically significant inhibition of granulocyte migration compared with controls.
Subject(s)
Asthma/genetics , Cell Migration Inhibition , Leukocytes/immunology , Adult , Asthma/immunology , Chemotaxis , Child , Child, Preschool , Humans , Skin Window TechniqueABSTRACT
The granulocytes obtained from patients with atopic diseases were investigated for their ability to engulf neutral latex particles and bacteria (S. aureus) in the presence of antigenically compatible sera of healthy subjects. Similar tests were done using the granulocytes of healthy subjects and sera of the patients with atopic diseases, and the granulocytes of these patients in autologous sera. Granulocytes of healthy subjects suspended in autologous sera served as a control. In all patients IgE globulins were determined in the serum. It was observed that only granulocytes from the patients with atopy showed a defect in engulfing latex particles and S. aureus. This defect was independent of the serum in which these granulocytes were suspended, and of the IgE level in the patient's serum.
