ABSTRACT
PURPOSE: The purpose of this paper was to describe this application, and to assess the sensitivity of the application when evaluating clinical interventions for improving balance and gait. METHODS: The records of fifteen consecutive patients referred to physical therapy for mobility problems or recent falls were reviewed for this study. The subjects were evaluated upon initial referral to physical therapy and after 30 days of treatment. Treatment was developed around the problems noted on initial evaluation and applied 5 days/week for 20 sessions. RESULTS: A Wilcoxon signed-rank comparison of the initial and 30 day re-evaluation of the balance and the gait assessment indicated that significant improvement had occurred in the balance scores (Z = -3.20, p = 0.001) and the gait scores (Z = -2.82, p = 0.005) in this group. CONCLUSION: These assessments are sensitive to clinical improvements in mobility among frail elders.
Subject(s)
Frail Elderly , Gait , Physical Therapy Modalities/methods , Postural Balance , Sensation Disorders/diagnosis , Sensation Disorders/rehabilitation , Accidental Falls , Aged , Aged, 80 and over , Female , Homes for the Aged , Humans , Male , Nursing Homes , Probability , Prognosis , Sensitivity and Specificity , Statistics, Nonparametric , Treatment OutcomeSubject(s)
Bacterial Vaccines/immunology , Borrelia/immunology , Lyme Disease/prevention & control , Vaccines, Synthetic/immunology , Adult , Animals , Bacterial Vaccines/administration & dosage , Bacterial Vaccines/adverse effects , Humans , Vaccines, Synthetic/administration & dosage , Vaccines, Synthetic/adverse effectsABSTRACT
A woman presented with a swollen red leg of 2 weeks' duration. Culture of the skin biopsy specimen confirmed this to be an infection caused by Sporothrix schenckii. Systemic evaluation led to the diagnosis of Cushing's disease and explained the unusual morphology. Treatment-related complications are also discussed.
Subject(s)
Cushing Syndrome/complications , Erythema/microbiology , Sporotrichosis/complications , Adult , Cushing Syndrome/diagnosis , Diagnosis, Differential , Erythema/diagnosis , Female , Humans , Leg , Sporothrix/isolation & purification , Sporotrichosis/diagnosis , Sporotrichosis/pathologyABSTRACT
An high-performance liquid chromatography method was developed that separates (5Z)-9 beta-methyl-6 alpha-carbaprostaglandin I2 (9 beta-methylcarbacyclin; ciprostene) from several closely related isomers: (i) a double bond isomer at C-5, (ii) an epimer at C-15, and (iii) combinations of i and ii. The method uses a Zorbax ODS column with a mobile phase consisting of acetonitrile-buffer pH 2.5 at a ratio of 45:55 for determination of purity and 40:60 for optimum separation of isomers. Detection is measurement of absorbance at 200 nm. Peak heights are measured relative to butylparaben which is used as an internal standard. The method is linear, free from interferences from degradation of ciprostene and has a relative standard deviation of 0.5-1% for solutions at 60 micrograms/ml. This assay has been applied to bulk powders and solutions of the drug. Stressed chemical stability studies have shown that the C-15 allylic secondary alcohol group undergoes epimerization under acidic conditions in solution and oxidation in the solid and solution state under thermal stress or in the presence of oxidants.
