ABSTRACT
Second malignancies following treatment for osteosarcoma are unusual. Breast cancer occurring in patients with osteosarcoma has been reported following therapeutic chest irradiation. We now report three cases of breast cancer occurring in young women who were successfully treated for osteosarcoma. These women had not received therapeutic chest irradiation and in two of the three women there was no family history of breast cancer. Peripheral blood was available for study from one case. Of import, this case demonstrated a germline mutation in exon 7 of the tumor suppressor gene, p53. The mutation was detected by constant denaturing gradient gel electrophoresis and confirmed by DNA sequencing. In this particular patient, inactivation of the p53 gene may be involved in the development of both the first and second malignancy.
Subject(s)
Bone Neoplasms/pathology , Breast Neoplasms/secondary , Genes, p53/genetics , Germ-Line Mutation , Osteosarcoma/secondary , Adult , Exons/genetics , Female , Humans , Osteosarcoma/geneticsSubject(s)
Agranulocytosis/drug therapy , Colony-Stimulating Factors/therapeutic use , Growth Substances/therapeutic use , Keratosis/congenital , Neutropenia/drug therapy , Adolescent , Anemia, Aplastic/complications , Ganciclovir/adverse effects , Granulocyte-Macrophage Colony-Stimulating Factor , Humans , Male , Neutropenia/chemically induced , Pancytopenia/complications , SyndromeSubject(s)
Anemia, Macrocytic/complications , Anemia, Megaloblastic/complications , Erythrocytes, Abnormal , Thalassemia/complications , Vitamin B 12 Deficiency/complications , Anemia, Megaloblastic/blood , Anemia, Megaloblastic/ethnology , Black People , Humans , Infant , Male , Proteinuria/blood , Syndrome , Thalassemia/blood , Vitamin B 12 Deficiency/blood , Vitamin B 12 Deficiency/ethnologySubject(s)
Arthrodesis , Metatarsophalangeal Joint/surgery , Toe Joint/surgery , Adult , Aged , Arthrodesis/methods , Female , Hallux Valgus/surgery , Humans , Male , Middle AgedABSTRACT
Mycetoma or Madura foot is a chronic infection of the foot characterized by swelling and multiple sinuses. The sinuses discharge pus composed of colored granules which contain the infecting organism. Although this entity is still rare in the United States, an increasing immigrant population and rapid air transportation have resulted in a greater number of cases being reported. A case of Madura foot is presented in which initial cultures yielded Staphylococcus aureus. Dicloxacillin was prescribed and this led to some improvement in the condition. Later, a gram-stained specimen of exudate from an inguinal site showed actinomycetes. Because of this finding, amoxicillin was then administered. As a result, the condition dramatically improved with subsequent healing of the involved bone.
