ABSTRACT
Dynamics of angiogenin content in the serum, thymus, bone marrow, and brain of mice was studied after intravenous injection. The maximum angiogenin retention was detected in the thymus, while high rate of its elimination in the brain.
Subject(s)
Brain/metabolism , Immunocompetence/physiology , Milk/physiology , Ribonuclease, Pancreatic/pharmacokinetics , Animals , Bone Marrow/metabolism , Male , Mice , Mice, Inbred BALB C , Thymus Gland/metabolism , Tissue DistributionABSTRACT
Angiogenin isolated from cow milk induces the production of cytokines IL-1beta, IL-6, and TNF-alpha in human leukocytes; the level of production of each cytokine depends on the concentration of the preparation, and the dynamics of production depends on the time from the beginning of induction. Simultaneous treatment with angiogenin and phytohemagglutinin had an additive effect on the production of cytokines, the time of this effect manifestation being individual for each cytokine.
Subject(s)
Interleukin-1/metabolism , Interleukin-6/metabolism , Leukocytes/immunology , Milk/chemistry , Ribonuclease, Pancreatic/physiology , Tumor Necrosis Factor-alpha/metabolism , Angiogenesis Inducing Agents/metabolism , Animals , Cattle , Humans , Phytohemagglutinins/pharmacology , Ribonuclease, Pancreatic/isolation & purification , Ribonuclease, Pancreatic/pharmacologyABSTRACT
We revealed a new property of angiogenin to restore the crystal structure of biological fluids (human blood plasma and exudates) impaired in various pathologies.
