ABSTRACT
In the Muheza region of Tanzania, an area with holoendemic malaria, the proportion of responders with IgG enzyme-linked immunosorbent assay reactivities to recombinant rhoptry-associated protein-1 (rRAP-1) as well as IgG reactivities to a repeat region of the acidic-basic repeat antigen (ABRA) increased with age. The proportion of responders with IgM reactivities to rRAP-1 increased with age in the first three decades. However, levels of IgG reactivities to rRAP-1 did not increase with age, indicating high levels of reactivities among young children. High P. falciparum densities were only detectable in children less than five years of age; in this group the proportion of IgG responders to rRAP-1 and to the ABRA repeat region was low but levels of IgG reactivities to rRAP-1 were inversely correlated with parasite density, suggesting that immune recognition of the antigen may be associated with resistance to infection. On the other hand, levels of IgG reactivities to the repeat region of ABRA increased with parasite densities in children 1-4 years of age. Two different profiles of IgG reactivities to rRAP-1 and to ABRA are detectable in young Tanzanian children and the Ig reactivities against rRAP-1 may be a component of the immune reactions restricting parasite multiplication.
Subject(s)
Immunoglobulin G/biosynthesis , Malaria, Falciparum/immunology , Parasitemia/immunology , Plasmodium falciparum/immunology , Protozoan Proteins/immunology , Age Factors , Analysis of Variance , Animals , Antibodies, Protozoan/biosynthesis , Antigens, Protozoan/immunology , Child , Child, Preschool , Enzyme-Linked Immunosorbent Assay , Humans , Immunoglobulin M/biosynthesis , Infant , Malaria, Falciparum/epidemiology , Malaria, Falciparum/parasitology , Parasitemia/epidemiology , Parasitemia/parasitology , Prevalence , Recombinant Proteins/immunology , Tanzania/epidemiologyABSTRACT
We report two cases of atrial septal aneurysm, one associated with paroxysmal supraventricular tachycardia, the second with atrial septal defect. In both cases there were verified some transitory ischemic attacks. Carotid ultrasonography excluded atherosclerosis lesions. Two-dimensional transthoracic echocardiography showed an atrial septal aneurysm which, in the second case, was associated with atrial septal defect as demonstrated by color Doppler. The therapy is discussed in the case of septal atrial aneurysm associated with transitory ischemic attack, anticoagulant therapy is indicated; in the other, surgical correction of the defect is necessary.
Subject(s)
Heart Aneurysm/diagnostic imaging , Heart Septal Defects, Atrial/diagnostic imaging , Ischemic Attack, Transient/etiology , Tachycardia, Paroxysmal/etiology , Adult , Echocardiography, Doppler, Color , Electroencephalography , Female , Heart Aneurysm/complications , Heart Aneurysm/surgery , Heart Septal Defects, Atrial/complications , Heart Septal Defects, Atrial/surgery , Humans , Ischemic Attack, Transient/diagnosis , Male , Middle Aged , Radiography, Thoracic , Tachycardia, Paroxysmal/diagnosisSubject(s)
Blood Viscosity , Myocardial Infarction/blood , Adult , Aged , Blood Flow Velocity , Erythrocytes/physiology , Female , Humans , Male , Middle Aged , RheologyABSTRACT
The synthesis of three series of N-monosubstituted urethanes of 6-cis-dialkylamino-1,3,3-trimethyl-2-oxabicyclo [2.2.2] octan-5-transols (IV), (V) and (VI) (dialkylamino = pyrrolidino, piperidino, morpholino) by reaction of the corresponding aminoalcohols with alkyl or aryl isocyanates, is described. A number of compounds (IV) and (V) showed remarkable hypotensive and bradycardic activity in rats, whereas (IV c) showed infiltration anesthesia and (IV n) antiarrhythmic activity in mice comparable to those of lidocaine. Antiacetylcholine activity in vitro is also reported.
Subject(s)
Amino Alcohols/chemical synthesis , Antihypertensive Agents/chemical synthesis , Acetylcholine/antagonists & inhibitors , Amino Alcohols/pharmacology , Anesthetics/chemical synthesis , Animals , Anti-Arrhythmia Agents/chemical synthesis , Chemical Phenomena , Chemistry , Heart Rate/drug effects , Mice , Urethane/analogs & derivatives , Urethane/chemical synthesis , Urethane/pharmacologyABSTRACT
Phosphocreatine has been shown having significant effects on striated skeletal musculature. In fact, it was shown, by experimental researches, that phosphocreatine interfered with the state of fatigue induced in the Mus musculus and in rats, by the swimming test.
Subject(s)
Muscles/physiology , Phosphocreatine/physiology , Animals , Fatigue/physiopathology , Male , Mice , RatsABSTRACT
In the rat, narcotic doses of Althesin injected intraperitoneally did not modify blood glucose concentration nor plasma insulin concentration. On the contrary a reduction of blood glucose concentration, associated with an increase of plasma insulin concentration was observed when narcotic doses of thiopental and ketamine were. Plasma renin concentration decreased after injection of Althesin and thiopental while increased after injection of ketamine.
