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J Pediatr ; 87(1): 16-22, 1975 Jul.
Article in English | MEDLINE | ID: mdl-168334

ABSTRACT

Idiopathic thrombocytopenic purpura in children 10 years of age or younger was observed to have a more favorable prognosis than in older children. Corticosteroid therapy in children judged to be at increased risk of serious hemorrhage resulted in a significantly greater number of patients with an early increase in platelets than was noted in a control group. All patients with chronic disease who responded to administration of a corticosteroid initially and then relapsed had some response to a subsequent course of therapy, although none had a sustained remission. In such patients, splenectomy was a more effective therapeutic measure than treatment with either a corticosteroid or a cytotoxic agent.


Subject(s)
Adrenal Cortex Hormones/therapeutic use , Hemorrhage/prevention & control , Immunosuppressive Agents/therapeutic use , Purpura, Thrombocytopenic/therapy , Adolescent , Adrenal Cortex Hormones/blood , Adrenocorticotropic Hormone/administration & dosage , Adrenocorticotropic Hormone/therapeutic use , Age Factors , Azathioprine/adverse effects , Azathioprine/therapeutic use , Blood Platelets/analysis , Child , Child, Preschool , Cortisone/therapeutic use , Female , Hemorrhage/drug therapy , Hemorrhage/etiology , Hemostasis , Humans , Infant , Male , Methylprednisolone/therapeutic use , Prednisone/therapeutic use , Purpura, Thrombocytopenic/blood , Purpura, Thrombocytopenic/complications , Seasons , Splenectomy
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