1.
Antibiot Khimioter
; 35(7): 5-8, 1990 Jul.
Article
in Russian
| MEDLINE
| ID: mdl-2285341
ABSTRACT
A procedure for developing a controlled process for biosynthesis of secondary metabolites is described with reference to rifamycin B as an example. The response of the antibiotic producing culture to changed concentrations of the main nutrients in the initial medium was determined. Mathematical processing of the experimental findings with design of the experiment resulted in defining nutrients such as ammonium sulfate and cornsteep liquor useful for further development of the controlled process.