Subject(s)
Asian People , Dermatology/instrumentation , Radiofrequency Therapy , Rejuvenation , Skin Aging , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedABSTRACT
BACKGROUND: Various repigmentation patterns such as perifollicular, marginal, diffuse, and mixed configuration can occur in vitiligo. The aim of this study was to clinically assess the types of repigmentation patterns obtained with narrow-band ultraviolet B (NBUVB) phototherapy or targeted phototherapy using a 308 nm excimer laser and to reveal whether the repigmentation patterns have any relationship to the location of lesions, patient's age, duration of lesions, or speed of improvement. METHODS: This study enrolled 51 patients who had effective responses as compared with baseline when treated with NBUVB alone and 52 patients who had effective responses as compared with baseline when treated with excimer laser alone. We evaluated the repigmentation patterns when the responses to treatments appeared. RESULTS: The most frequent repigmentation pattern was the perifollicular type in both groups treated with NBUVB (42.2%) or excimer laser (51.3%), followed by marginal, diffuse, and combined, in that order. There was no significant difference in the repigmentation pattern according to the location of lesions, patient's age, or duration of lesions. The marginal pattern was predominant in both NBUVB and excimer laser-treated groups when excellent responses (more than 75% repigmentation achieved at 12 weeks) appeared. CONCLUSIONS: The repigmentation patterns according to location, age, duration of lesions, and speed of response showed similarities in both the NBUVB and excimer laser-treated groups.
Subject(s)
Lasers, Excimer/therapeutic use , Low-Level Light Therapy/methods , Skin Pigmentation/radiation effects , Ultraviolet Therapy/methods , Vitiligo/radiotherapy , Adolescent , Aged , Asian People , Child , Child, Preschool , Dose-Response Relationship, Radiation , Female , Humans , Korea , Male , Middle Aged , Treatment Outcome , Young AdultABSTRACT
Human placental extract is used in the treatment of skin wrinkles and wounds. To date, no studies have evaluated the effects of placental extract on dermal fibroblast proliferation. To investigate the effects of placental extract versus ascorbic acid on fibroblast proliferation and transforming growth factor (TGF)-beta1 expression, cultured human fibroblasts were treated with placental extract (0, 0.08, 0.16, 0.32, and 0.64%) or L-ascorbic acid-2-phosphate magnesium (0, 0.01, 0.1, 1.0, and 10 mM). Fibroblast proliferation was determined by MTT assay, and TGF-beta1 protein expression was analyzed by ELISA. The proliferation of fibroblasts increased significantly after treatment with placental extract at concentrations of 0.32 and 0.64% and with L-ascorbic acid-2-phosphate magnesium at concentrations of 1.0 and 10 mM. Placental extract demonstrated no significant effects on TGF-beta1 expression; however, TGF-beta1 expression significantly increased after treatment with ascorbic acid at concentrations of 1.0 and 10 mM. Placental extract and ascorbic acid had similar effects on fibroblast proliferation; however, placental extract did not significantly increase TGF-beta1 protein expression.
