[Comparison of the effects of molsidomine retard and isosorbide dinitrate retard in patients with stable angina pectoris using an ergometry test]. / Srovnání úcinku retardovaného molsidominu a retardovaného isosorbiddinitrátu u nemocných se stabilní anginou pectoris pomocí ergometrického vysetrení.

In 24 men with angina after exertion the authors assessed, using ergometry, the action of molsidomine retard and isosorbide dinitrate retard after a single dose and after tree-week administration of the drug. The authors found that 8 mg of molsidomine retard in a single dose had a somewhat more potent effect than 40 mg isosorbide dinitrate retard. After prolonged administration the effect of both drugs on haemodynamics diminished and in molsidomine a significant decline of action was observed before development of a reduced S-T segment on the ECG. After three weeks' administration the effects of both drugs were comparable. After neither drug clinically significant tolerance developed when the drug was administered every 8 hours. In the conclusion the authors discuss possible mechanisms involved in development of tolerance.

The UK Human Genome Mapping Project online computing service.

This paper presents an overview of computing and networking facilities developed by the Medical Research Council to provide online computing support to the Human Genome Mapping Project (HGMP) in the UK. The facility is connected to a number of other computing facilities in various centres of genetics and molecular biology research excellence, either directly via high-speed links or through national and international wide-area networks. The paper describes the design and implementation of the current system, a 'client/server' network of Sun, IBM, DEC and Apple servers, gateways and workstations. A short outline of online computing services currently delivered by this system to the UK human genetics research community is also provided. More information about the services and their availability could be obtained by a direct approach to the UK HGMP-RC.

[Intravenous streptokinase in the treatment of acute myocardial infarct]. / Nitrozilní streptokináza v lécbe cerstvého srdecního infarktu.

In 314 patients with a first myocardial infarction, admitted within four hours after development of symptoms, the authors used in addition to standard therapy heparin treatment in 205 and streptokinase treatment (1.5 mil. u. i.v. with subsequent i.v. heparin administration) in 109 patients. Thrombolytic treatment was more effective, it reduced the lethality by 55.7% and was associated with a lower incidence of complications during the first 30 days. The reduced lethality, however, did not reach statistical significance because of the small number of patients and the low mortality rate in both groups. The left ventricular ejection fraction was practically equal in both groups after six weeks. Undesirable effects of thrombolytic therapy were rare and did not seriously threaten the patients. Provided contraindications are carefully respected, this treatment is safe and its routine use in the treatment of new myocardial infarctions must be supported. Streptokinase remains the drug of choice because it is equally effective as other available fibrinolytics and is the cheapest one.

[The effect of molsidomine on bicycle ergometry in patients with stable angina pectoris]. / Vliv molsidominu na prubeh bicyklové ergometrie u nemocných se stabilní anginou pectoris.

The authors investigated the effect of a single dose of 4 mg molsidomine on the course of bicycle ergometry. This effect was compared with that of 120 mg isosorbide dinitrate retard and with placebo. Isosorbide dinitrate in this large dose significantly protracted the period before angina pectoris developed after exercise, it significantly reduced the duration of stenocardias, significantly increased the total work output, significantly prolonged the period before a reduction of the ST segment occurred on the ECG and significantly reduced the values of reduction of the ST segments. Moisidomine in medium doses significantly protracted the period before angina pectoris developed after exercise and significantly increased the total work output. After comparison of the described results with those of investigations where smaller doses of isosorbide dinitrate were used, the authors assume that after increasing the dose of molsidomine its effect will be comparable with large nitrate doses.

[Does coronary pathomorphology affect the anti-anginal and anti-ischemic effects of diltiazem in patients with chronic stable angina pectoris?]. / Ovlivnuje koronární patomorfologie antianginózní a antiischemický úcinek diltiazemu u nemocných s chronickou stabilní anginou pectoris?

The authors compared by means of bicycle ergometry the effect of a single dose of 90 mg diltiazem (Dilzem Gödecke Co.) and placebo in 31 patients with chronic stable angina pectoris grade II-III according to NYHA. These patients were divided into group A where the pathomorphology of the coronary circulation made the "steal phenomenon" possible and group B where there were no conditions for the "steal phenomenon". Diltiazem, as compared with placebo, increased significantly in both groups the total work output during ergometric examination, delayed significantly the onset of stenocardia and the time before the development of a 1 mm depression of the ST segment; in group A it significantly reduced the depression of the ST segment during the maximum equal load achieved with diltiazem and placebo; it significantly reduced the diastolic blood pressure at rest and during exercise, it significantly reduced the heart rate in group B during exercise. The differences in the action of diltiazem, as compared with placebo, between the two compared groups A and B were not significant in any of the investigated parameters. Administration of diltiazem had a very favourable anti-anginal and anti-ischaemic action in both groups of patients, regardless of the morphology of the coronary affection.