[Genotypes of ACE gene in Kazakh and Uygur patients with ischemic heart disease]. / Genotipy gena angiotenzinprevrashchaiushchego fermenta u bol'nykh IBC -- lits kazakhskoi i uigurskoi natsional'nostei.

Frequency distribution of angiotensin-converting enzyme (ACE) gene genotypes and alleles was studied in patients with ischemic heart disease (IHD) and healthy subjects of Kazakh and Yugur nationalities. Polymorphism of ACE gene was determined by means of polymerase chain reaction. 88 IHD and 72 healthy Kazakhs and 70 and 70 Yugurs, respectively, were examined. Incidence of DD genotype in the studied groups was the least. This agrees with the literature data about low occurrence of genotype DD in Asian nationalities. Frequency of ACE gene genotypes in IHD and healthy subjects of Kazakh and Yugur nationalities do not differ significantly. Thus, polymorphism of ACE gene is unrelated to IHD in the examinees.

[Apolipoprotein genes in patients with ischemic heart disease]. / Geny apolipoproteinov u bol'nykh s ishemicheskoi bolezn'iu serdtsa.

The role of allele variants of apoB, apoCIII, and apoE genes in genetical predisposition to coronary disease was studied in Kazakhs and Uigurs. A total of 241 coronary patients and 205 healthy controls (all males) were examined. ApoB, apoCIII, and apoE gene polymorphism was studied by the polymerase chain reaction with thermostable Tag DNA polymerase. No significant relationship between the studied genes polymorphism and coronary disease was detected in the Kazakhs and Uigurs.

[Free-radical lipid peroxidation in acute myocardial infarction complicated by cardiogenic shock]. / Svobodnoradikal'noe okislenie lipidov pri ostrom infarkte miokarda, oslozhnennom kardiogennym shokom.

The pattern of variation in primary and end products of erythrocyte lipid peroxidation (LPO) was examined in 131 patients with acute myocardial infarction. The levels of LPO products were found to be increased dramatically, the magnitude and duration of the increase being dependent on the severity of cardiogenic shock complicating myocardial infarction. The changes were particularly marked in true cardiogenic shock. The level of LPO products fell significantly on day 2-3 of myocardial infarction where it stabilized until the end of the study in patients with uncomplicated infarction treated with alpha-tocopherol acetate in addition to a symptomatic therapy. This pattern is attributed to an inhibitory effect this antioxidant may have on LPO.

[Activity of various organ-specific liver enzymes in patients with myocardial infarction complicated by cardiogenic shock]. / Aktivnost' nekotorykh organospetsificheskikh fermentov pecheni u bol'nykh infarktom miokarda, oslozhnennym kardiogennym shokom.

The activity of some organ specific enzymes of the liver subcellular structures in the blood serum was examined in 56 patients with cardiogenic shock. The correlation between the gravity of clinical signs of cardiogenic shock and blood enzyme degree was revealed. It was concluded that biochemical criteria could be used in the diagnosis of irreversible changes in the liver in cardiogenic shock.

[Prevention of stress disorders of myocardial contractile function using membrane protectors]. / Preduprezhdenie stressornykh narushenii sokratitel'noi funktsii miokarda s pomoshch'iu membranoprotektorov.

The effect of preliminary administration of the adrenoblocker inderal, the lipase inhibitor nicotinamide, and the phospholipase inhibitor chloroquine on the disturbance of the myocardium extensibility and contractile function, the decrease of its resistance to hypoxia and to the calcium excess usually caused by emotional-painful stress was studied on the isolated rat atrium. It was established that these drugs prevented the above post-stress disturbances without significant affection of control animals. Nicotinamide was found to be the most effective, its protective action on the myocardium was accompanied by the prevention of the stress-induced increase of free fatty acids in the blood. The whole complex of data suggests that together with the activation of lipid peroxidation, the activation of lipases and phospholipases the damaging action of fatty acids play a role in the stress-induced damage; it also gives bases to use the factors stabilizing the membranous lipid bilayer for the heart protection against the stress-induced damages.