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Bioorg Med Chem Lett
; 24(21): 5093-7, 2014 11 01.
Article
in English
| MEDLINE
| ID: mdl-25282552
ABSTRACT
We report a series of phenyl substituted pyridazin-3-ones substituted with morpholino-pyrimidines. The SAR of the phenyl was explored and their c-Met kinase and cell-based inhibitory activity toward c-Met driven cell lines were evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent morpholino-pyridazinone scaffold, with particular focus on the phenyl and pyrimidine substituents.