ABSTRACT
Per- and polyfluoroalkyl substances (PFAS) make up a large group of persistent anthropogenic chemicals which are difficult to degrade and/or destroy. PFAS are an emerging class of contaminants, but little is known about the long-term health effects related to exposure. In addition, technologies to identify levels of contamination in the environment and to remediate contaminated sites are currently inadequate. In this opinion-type discussion paper, a team of researchers from the University of Connecticut and the University at Albany discuss the scientific challenges in their specific but intertwined PFAS research areas, including rapid and low-cost detection, energy-saving remediation, the role of T helper cells in immunotoxicity, and the biochemical and molecular effects of PFAS among community residents with measurable PFAS concentrations. Potential research directions that may be employed to address those challenges and improve the understanding of sensing, remediation, exposure to, and health effects of PFAS are then presented. We hope our account of emerging problems related to PFAS contamination will encourage a broad range of scientific experts to bring these research initiatives addressing PFAS into play on a national scale.
ABSTRACT
As an emerging contaminant, per- and polyfluoroalkyl substances (PFASs) make up a large group of persistent anthropogenic chemicals, which are difficult to degrade in the environment. Notwithstanding their wide range of applications in consumer products and industrial processes, PFASs have been detected in the environment as well as in human body. Due to their potential adverse human health effects, the U.S. Environmental Protection Agency (EPA) set the combined concentration of PFOA and PFOS in drinking water at 70 ng/L or 70 ppt (parts per trillion) as a lifetime health advisory level. Current standard detection methods for PFASs heavily rely on chromatographic techniques coupled with mass spectrometry. Although these methods provide accurate, specific, and sensitive measurements, their applications are greatly limited in advanced analytical laboratories because it necessitates expensive instrumentations, professional operators, complicated sample pretreatment, and considerable analysis time. Therefore, other detection methods beyond chromatographic based techniques, such as optical and electrochemical techniques, have also been extensively explored for simple, accessible, inexpensive, rapid, and sensitive detection of PFASs, particularly PFOA and PFOS. The purpose of this review is to provide recent progress in alternative detection platforms relying on non-MS based techniques for PFASs analysis. Starting with a brief introduction about the importance of monitoring PFASs, recent advances in various PFASs detection methods are grouped and discussed based on the difference of signals, with an emphasis on the working principles of different techniques, the sensing mechanism, and the sensing performance. The review is closed with the conclusion and discussion of future trends.
