ABSTRACT
Helminth infections are prevalent in Lao People's Democratic Republic (Lao PDR). This study aimed at determining the prevalence and risk factors of intestinal helminthiasis in remote mountainous villages of northern Lao PDR. During the dry season in January 2017, a cross-sectional survey was conducted in 3 remote mountainous villages in Oudomxay province, Lao PDR. Villagers older than 18 years of age who agreed to submit stool samples or undergo an interview, were recruited. Stool samples from 198 individuals were examined by the Kato-Katz method, and a questionnaire surveyed 161 individuals among them. Univariable and multivariable logistic regression analyses were used to identify risk factors associated with the intestinal helminthiasis. An overall prevalence of intestinal helminthiasis was 75.8%. Hookworm infection was the most common (63.1%), followed by Opisthorchis viverrini/minute intestinal flukes (17.7%), Taenia spp. (15.2%), Trichuris trichiura (2.0%), Ascaris lumbricoides (1.5%), and Enterobius vermicularis (1.0%). Questionnaire analysis revealed sex (male) and absence of latrine to be significant risk factors for hookworm infection and consumption of raw meat for taeniasis. These results suggest that the mountainous area in northern Lao PDR has a different composition of helminth infections from other studies conducted in Lao PDR; a high prevalence of hookworm infection and taeniasis and low prevalence of T. trichiura and A. lumbricoides infections were observed. Also, liver flukes or intestinal flukes were similarly prevalent in the mountainous area.
Subject(s)
Helminthiasis/parasitology , Helminths/isolation & purification , Intestinal Diseases, Parasitic/parasitology , Adolescent , Adult , Aged , Aged, 80 and over , Animals , Child , Cross-Sectional Studies , Feces/parasitology , Female , Helminthiasis/epidemiology , Helminths/classification , Helminths/genetics , Humans , Intestinal Diseases, Parasitic/epidemiology , Laos/epidemiology , Male , Middle Aged , Rural Health , Young AdultABSTRACT
Urogenital schistosomiasis (UGS) is one of the important neglected tropical diseases, which requires global elimination programs. It is primarily diagnosed by urine microscopy (UM), but its sensitivity is not satisfactory. Ultrasonography (US) is an alternative screening method of UGS. The present study investigated the diagnostic feasibility of new criteria including echogenic snow sign, innumerable scattered small echogenic foci floating in bladder lumen, for UGS in White Nile State, Republic of Sudan, 2013-2014. A total of 1,462 participants were screened by US or UM, and 948 by both. The 948 subjects were 1-80 years of age, 485 (51.2%) of them were boys or men, and 648 (68.4%) were less than 15 years of age. Eggs were detected from 133 (14.0%) by UM. The US findings of bladder wall thickening, polypoid mass, and ureter dilatation were regarded as positive for UGS following the World Health Organization (WHO) guidelines. Of the 948 subjects, 155 (16.4%) were positive for US by the WHO criteria. The echogenic snow sign was detected in 75 participants, and was most frequently observed in age group of 10-14. It was more commonly observed in UM-positive participants (35/133; 26.3%) than in UM-negative participants (40/815; 4.9%), and the difference was statistically significant with an odds ratio of 6.92 (4.20-11.41). When the echogenic snow was added to the WHO criteria, 42 participants were additionally revealed to have UGS-related morbidity, reaching a total of 198 (20.9%) participants. The echogenic snow sign can be suggested as a new finding to the criteria of US for UGS.
