[The ultrastructural organization of the liver of rats with experimental hepatitis after drinking mineral water containing humic acids].

We undertook the ultrastructural analysis of liver parenchyma taken from male rats with experimental hepatitis induced by the administration of paracetamol at a dose of 1000 mg per 1 kg body weight either following a course of drinking mineral water containing humic acids at a concentration of 20 mg/sq. decimeter) or 14 days after the termination of the drug action (the after-effect phase). It was shown that the consumption of mineral water during 21 days resulted in the modification of the ultrastructural organization of hepatocytes apparent as the increased amount of cisterns in the granulosa endoplasmic system, glycogen rosettes, and mitochondrial polymorphism. These changes give evidence of the restoration of the energy, glycogen and protein synthesizing functions disturbed by paracetamol administration. The after-effect phase was characterized by the further strengthening of reparative processes and the functional activity of hepatic cells.

[Structural changes in heart at experimental widespread purulent peritonitis].

Structural changes in the heart are studied at an experimental widespread purulent peritonitis. It was established that in 6 hours after initiation of peritonitis in a myocardium the severe disorders of blood circulation, interstitial edema, the phenomena of kariopyknosis, development of systemic toxic damages specifying in high speed at this disease were observed. One of the mechanism of their development is a energy deficiency. The proof of this is destructive changes of cardiomyocytes mitochondria. The comparative analysis of use of metabolic preparations "Citoflavin", containing amber acid, and "Neoton", containing phosphocreatine, for the purpose of pharmacological support of cardiac activity at an experimental widespread purulent peritonitis has revealed high efficiency of the preparation "Citoflavin". It caused more intensive decrease of inflammatory changes in a myocardium, preventing of cardiomyocytes necrobiosis, contribution to preservation of normal structure and growth of quantity of mitochondria.

[Sympathetic innervation of various endocrine organs in chronic action of lead acetate]. / Simpaticheskaia innervatsiia nekotorykh éndokrinnykh organov pri khronicheskom deistvii atsetata svintsa.

Structure and innervation of paraventricular and supraoptic hypothalamic nuclei, thyroid gland, adrenals and ovaries were studied by methods of histochemistry and electron microscopy in guinea pigs following chronic treatment with lead acetate in doses 50.10 and 0.1 mg/kg per day. A certain dependence between sympathoadrenal system activity and morphofunctional parameters of the endocrine organs studied was established, which is determined by the pathogenic factor dose and duration of effect.

[The reaction of the thyroid neural structures in guinea pigs to ionizing radiation exposure]. / Reaktsiia nervnykh struktur shchitovidnoi zhelezy morskikh svinok na vozdeistvie ioniziruiushchei radiatsii.

State and structural organization of the guinea pig thyroid gland were studied histochemically in distanced terms (6 months) after the single external x-ray radiation 12.9 C/kg in doze. with the following intraperitoneal introduction of 131 6.5 C/kg in doze. Atrophically changed zones of parenchyma were observed along with regions of extra- and intrafollicular hyperplasia with compensatory-adaptive manifestations aimed at hormonopoiesis increase. Growth of sympathetic innervation of the vessel walls and around the follicles were found in areas of high functional activity. Direct contact between adrenergic axons and thyrocytes was demonstrated by means of electron microscopy. In parenchyma areas with signs of atrophia, adrenergic nerve fibers and terminals are located only in vessels. Thus, connection between the state of the thyroid gland sympathetic innervation and structural organization of its parenchyma in distanced terms of radiational effects was followed up.

[Morphofunctional characteristics of the ovaries, thyroid gland and adrenal glands in experimental lead acetate poisoning]. / Morfofunktsional'naia kharakteristika iaichnikov, shchitovidnoi zhelezy i nadpochechnikov pri éksperimental'nom otravlenii uksusnokislym svintsom.

Daily doses of 50 mg/kg of lead acetate injected into the laboratory animals induce morphologic changes in the parenchyma of ovaries, thyroid gland, adrenals and compromises neural mediating processes in paraventricular and supraoptic nuclei of hypothalamus. The observed morphologic changes are similar to those characteristic for intensive functioning. Prolonged exposure to lead acetate (daily dose 10 mg/kg) results in adaptation and compensation, which preserves the functional potential of the organs. The morphologic changes in the endocrine organs do not lead to significant hormonal changes.

[Functional morphology of the neural apparatus of the hen ovary in postnatal ontogeny]. / Funktsional'naia morfologiia nervnogo apparata iaichnika kurits v postnatal'nom ontogeneze.

When comparing the data of neurohistochemical and electron microscopic investigations in the hen and chick ovaries, adrenergic, cholinergic and, possibly, peptidergic nerve fibers have been identified. Previously described cells in the follicular internal theca are mainly SIF-cells and AChE-positive neurocytes of afferent and efferent nature. Axonal terminals make synaptic (or synaptic-like) contacts with chromaffin cells, thecocytes, pericytes of capillaries, AChE-positive motor neurons. Integral estimation, taking into account informative parameters, demonstrates that the degree of the neuromediator differentiation and age resistivity of nervous structures correlates the gland steroidogenic activity. The vascular adrenergic apparatus and chromaffin cells can be considered as potential sources of innervation and catecholamines, able to perform a compensatory function at ageing and other conditions, that are accompanied with a local deficit of sympathetic mediation.