[A comparative clinico-pharmacokinetic study of the use of equivalent daily doses of lithium carbonate and Contemnol]. / Sravnitel'noe kliniko-farmakokineticheskoe issledovanie primeneniia ékvivalentnykh sutochnykh doz karbonata litiia i kontemnola.

Comparative study of the influence of equivalent doses of lithium carbonate and contemnol was studied in patients with phasic development of endogenous psychoses. 33 patients (17 men, 16 women) of 20-58 years or age were treated. According to IDC-10 there were observed schizoaffective psychoses in 22 patients (F25), bipolar affective disorders in 5 patients (F31) and chronic mood disorders in 5 individuals (F34). 2-daily comparative pharmacokinetic profiles of lithium carbonate and contemnol were presented and on the base of standard statistic analysis were estimated: lithium presence in blood, amplitude of variations of lithium concentration, number of peak concentrations, areas under pharmacokinetic curves. The study showed that concentration of lithium in blood increased gradually and achieved the maximal level in 6-7 hours after contemnol administration and was not practically changed during following 24 hours as compared to lithium carbonate. The results of the study confirmed that contemnol occurred to be the prolong of lithium carbonate and hadn't to be used more frequently than once a day.