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Neuroscience ; 158(2): 365-8, 2009 Jan 23.
Article in English | MEDLINE | ID: mdl-18996172

ABSTRACT

Cadherin23 has been proposed to form the upper part of the tip link, an interstereocilial link believed to control opening of transducer channels of sensory hair cells. However, we detect tip link-like links in mouse mutants with null alleles of Cdh23, suggesting the presence of other components that permit formation of a link between the tip of one stereocilium and the side of the adjacent taller stereocilium.


Subject(s)
Cadherins/physiology , Mutation , Animals , Animals, Newborn , Cadherins/genetics , Cilia/ultrastructure , Hair Cells, Auditory, Inner/physiology , Hair Cells, Auditory, Inner/ultrastructure , Mice , Mice, Mutant Strains , Microscopy, Electron, Scanning/methods
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