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Mol Gen Mikrobiol Virusol ; 34(1): 13-8, 2016.
Article in Russian | MEDLINE | ID: mdl-27183716

ABSTRACT

The facultative aerobic bacteria isolated from the mucosa of rectum in patients with colorectal cancer in the zone of malignant tumor and neighboring normal mucosa was studied using molecular-genetic methods. The species attribution of bacteria was implemented using the cultural-morphological analysis and sequencing of the 16S rRNA locus. The microorganisms with the intraepithelial invasion to rectal mucosa isolated were identified as representatives of the adherent-invasive (AIEC) subgroup of Escherichia coli and species Klebsiella pneumonia. The molecular analysis by genetic determinants controlling adhesive, hemolytic, and toxigenic activity revealed that some bacterial isolates were able to produce toxins with potential cancerogenic activity (e.g., colibactin and cytotoxic necrotic factor I). Certain bacterial species isolated from malignant and normal rectum epithelium of the same patient demonstrated no difference between analyzed factors of toxigenicity.


Subject(s)
Colorectal Neoplasms/microbiology , Escherichia coli , Intestinal Mucosa/microbiology , Klebsiella pneumoniae , RNA, Bacterial/genetics , RNA, Ribosomal, 16S/genetics , Colorectal Neoplasms/pathology , Escherichia coli/genetics , Escherichia coli/isolation & purification , Escherichia coli/pathogenicity , Female , Humans , Intestinal Mucosa/pathology , Klebsiella pneumoniae/genetics , Klebsiella pneumoniae/isolation & purification , Klebsiella pneumoniae/pathogenicity , Male
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